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Wei Jiang M.D.,Ph.D.

Provider Image
Rank
  • Assistant Professor
College
  • College of Medicine
Department
  • Microbiology and Immunology
Academic Focus
  • B cell dysfunction in HIV immuno-pathogenesis
  • Toll-like receptors and agonists, microbial translocation, gut permeability, antigen-presenting cells
  • Gender differences in immune function and disease pathogenesis, e.g., HIV, SLE

Locations

Office Location
street
room

Biography

Key differences in B cell activation patterns and immune correlates among treated HIV-infected patients versus healthy controls following influenza vaccination.

Luo Z, Ma L, Zhang L, Martin L, Wan Z, Warth S, Kilby A, Gao Y, Bhargava P, Li Z, Wu H, Meissner EG, Li Z, Kilby JM, Liao G, Jiang W.

Vaccine. 2016; 34(16):1945-55. NIHMSID: NIHMS747556

PubMed [journal]
PMID:
 
26721328
 
PMCID:
 
PMC4803607
2.

Humoral immune responses to Streptococcus pneumoniae in the setting of HIV-1 infection.

Zhang L, Li Z, Wan Z, Kilby A, Kilby JM, Jiang W.

Vaccine. 2015; 33(36):4430-6. NIHMSID: NIHMS702031

PubMed [journal]
PMID:
 
26141012
 
PMCID:
 
PMC4547882
3.

Soluble CD14 is a nonspecific marker of monocyte activation.

Shive CL, Jiang W, Anthony DD, Lederman MM.

AIDS (London, England). 2015; 29(10):1263-5. NIHMSID: NIHMS687458

PubMed [journal]
PMID:
 
26035325
 
PMCID:
 
PMC4452959
4.

HIV-associated memory B cell perturbations.

Hu Z, Luo Z, Wan Z, Wu H, Li W, Zhang T, Jiang W.

Vaccine. 2015; 33(22):2524-9. NIHMSID: NIHMS678011

PubMed [journal]
PMID:
 
25887082
 
PMCID:
 
PMC4420662
5.

Plasmacytoid dendritic cells mediate synergistic effects of HIV and lipopolysaccharide on CD27+ IgD- memory B cell apoptosis.

Zhang L, Luo Z, Sieg SF, Funderburg NT, Yu X, Fu P, Wu H, Jiao Y, Gao Y, Greenspan NS, Harding CV, Kilby JM, Li Z, Lederman MM, Jiang W.

Journal of virology. 2014; 88(19):11430-41.

PubMed [journal]
PMID:
 
25056888
 
PMCID:
 
PMC4178795
6.

Cycling memory CD4+ T cells in HIV disease have a diverse T cell receptor repertoire and a phenotype consistent with bystander activation.

Jiang W, Younes SA, Funderburg NT, Mudd JC, Espinosa E, Davenport MP, Babineau DC, Sieg SF, Lederman MM.

Journal of virology. 2014; 88(10):5369-80.

PubMed [journal]
PMID:
 
24522925
 
PMCID:
 
PMC4019138
7.

Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE).

Jiang W, Gilkeson G.

Journal of immunotherapy applications. 2014; 1:1. NIHMSID: NIHMS570291

PubMed [journal]
PMID:
 
25309746
 
PMCID:
 
PMC4193900
8.

Sex differences in monocyte activation in systemic lupus erythematosus (SLE).

Jiang W, Zhang L, Lang R, Li Z, Gilkeson G.

PloS one. 2014; 9(12):e114589.

PubMed [journal]
PMID:
 
25485543
 
PMCID:
 
PMC4259347
9.

Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease.

Yu X, Li Z, Zhou Z, Kilby JM, Jiang W.

Epidemiology (Sunnyvale, Calif.). 2013; 3:120. NIHMSID: NIHMS572915

PubMed [journal]
PMID:
 
24795844
 
PMCID:
 
PMC4005894
10.

Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers.

Hardy GA, Sieg S, Rodriguez B, Anthony D, Asaad R, Jiang W, Mudd J, Schacker T, Funderburg NT, Pilch-Cooper HA, Debernardo R, Rabin RL, Lederman MM, Harding CV.

PloS one. 2013; 8(2):e56527.

PubMed [journal]
PMID:
 
23437155
 
PMCID:
 
PMC3577907

 

 

 

Bacterial colonization and beta defensins in the female genital tract in HIV infection.

Jiang W, Ghosh SK, Flyckt R, Kalinowska M, Starks D, Jurevic R, Weinberg A, Lederman MM, Rodriguez B.

Current HIV research. 2012; 10(6):504-12. NIHMSID: NIHMS400345

PubMed [journal]
PMID:
 
22716110
 
PMCID:
 
PMC3427638
12.

Microbial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus Disease.

Jiang W.

American journal of immunology. 2012; 8(2):44-51. NIHMSID: NIHMS480749

PubMed [journal]
PMID:
 
23869197
 
PMCID:
 
PMC3712352
13.

Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells.

Jiang W, Lederman MM, Harding CV, Sieg SF.

Journal of immunology (Baltimore, Md. : 1950). 2011; 186(4):2080-6. NIHMSID: NIHMS265059

PubMed [journal]
PMID:
 
21239717
 
PMCID:
 
PMC3039025
14.

Intracellular Casp8p41 content is inversely associated with CD4 T cell count.

Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD.

The Journal of infectious diseases. 2010; 202(3):386-91. NIHMSID: NIHMS215916

PubMed [journal]
PMID:
 
20565257
 
PMCID:
 
PMC2906377
15.

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.

Funderburg NT, Mayne E, Sieg SF, Asaad R, Jiang W, Kalinowska M, Luciano AA, Stevens W, Rodriguez B, Brenchley JM, Douek DC, Lederman MM.

Blood. 2010; 115(2):161-7.

PubMed [journal]
PMID:
 
19828697
 
PMCID:
 
PMC2808148
16.

Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression.

Hardy GA, Sieg SF, Rodriguez B, Jiang W, Asaad R, Lederman MM, Harding CV.

Blood. 2009; 113(22):5497-505.

PubMed [journal]
PMID:
 
19299650
 
PMCID:
 
PMC2689050
17.

Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection.

Jiang W, Lederman MM, Hunt P, Sieg SF, Haley K, Rodriguez B, Landay A, Martin J, Sinclair E, Asher AI, Deeks SG, Douek DC, Brenchley JM.

The Journal of infectious diseases. 2009; 199(8):1177-85. NIHMSID: NIHMS106700

PubMed [journal]
PMID:
 
19265479
 
PMCID:
 
PMC2728622
18.

Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection.

Jiang W, Lederman MM, Mohner RJ, Rodriguez B, Nedrich TM, Harding CV, Sieg SF.

Journal of virology. 2008; 82(16):7837-45.

PubMed [journal]
PMID:
 
18524824
 
PMCID:
 
PMC2519583
19.

Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis.

Funderburg N, Luciano AA, Jiang W, Rodriguez B, Sieg SF, Lederman MM.

PloS one. 2008; 3(4):e1915.

PubMed [journal]
PMID:
 
18382686
 
PMCID:
 
PMC2271052
20.

TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function.

Jiang W, Lederman MM, Harding CV, Rodriguez B, Mohner RJ, Sieg SF.

European journal of immunology. 2007; 37(8):2205-13.

PubMed [journal]
PMID:
 
17621369

Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection.

Rodriguez B, Lederman MM, Jiang W, Bazdar DA, Gàrate K, Harding CV, Sieg SF.

AIDS (London, England). 2006; 20(10):1379-89.

PubMed [journal]
PMID:
 
16791012
22.

Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement.

Sieg SF, Rodriguez B, Asaad R, Jiang W, Bazdar DA, Lederman MM.

The Journal of infectious diseases. 2005; 192(1):62-70.

PubMed [journal]
PMID:
 
15942895
23.

Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and production.

Jiang W, Lederman MM, Salkowitz JR, Rodriguez B, Harding CV, Sieg SF.

Journal of virology. 2005; 79(7):4109-19.

PubMed [journal]
PMID:
 
15767412
 
PMCID:
 
PMC1061539