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Laboratory of Anna Liisa Neiminen

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Recent Publications

  • Chiu, S.-M., Xue, L.-Y., Lam, M., Rodriguez, M.E., Zhang, P., Kenney, M.E., Nieminen, A.-L., and Oleinick, N.L.  (2010) A requirement for bid for induction of apoptosis by photodynamic therapy with a lysosome- but not a mitochondrion-targeted photosensitizer. Photochem. Photobiol., Jun 14. [Epub ahead of print]

  • Quiogue, G., Saggu, S., Hung, H.-I., Kenney, M.E., Oleinick, N.L., Lemasters, J.J., and Nieminen, A.-L. (2009) Signaling from lysosomes enhances mitochondria-mediated photodynamic therapy in cancer cells.  Proc. Soc. Photo. Opt. Instrum. Eng. 7380, 1-8.

  • Rodriguez, M.E., Azizuddin, K., Chiu, S.-M., Xue, L.-Y., Zhang, P., Lam, M., Kenney, M.E., Nieminen, A.-L., and Oleinick, N.L. (2009) Structural factors and mechanisms underlying the improved photodynamic    cell killing with silicon phthalocyanine photosensitizers directed to lysosomes vs. mitochondria. Photochem. Photobiol. 85, 1189-1200.

  • Lemasters, J.J., Theruvath, T.P., Zhong, Z., and Nieminen, A.-L. (2009) Mitochondrial calcium and permeability transition in cell death. Biochim. Biophys. Acta 1787, 1395-1401.

  • Qanungo, S., Starke, D.W., Pai, H., Mieyal, J.J., and Nieminen, A.-L. (2007) Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkB. J. Biol. Chem. 282, 18427-18436.

  • Oleinick, N.L., Morris, R.L., and Nieminen, A.-L. (2007) Photodynamic Therapy-Induced Apoptosis. In Apoptosis, Senescence, and Cancer, D.A. Gewritz, S.E. Holt and S. Grant, Eds., Series on Cancer Drug Development, Humana Press, Inc., Totowa, NJ, 555-576.

  • Nieminen, A.-L., Qanungo, S., Schneider, E.A., Jiang, B.-H., and Agani, F.H. (2005) Mdm2 stimulates HIF-1 during hypoxia. J. Cell Physiol. 204, 364-369.

  • Wang, M. Qanungo, S., Crow, M., Watanabe, M., and Nieminen, A.-L. (2005) Apoptosis repressor with caspase recruitment domain is expressed in cancer cells and localizes to nuclei. FEBS Lett. 579, 2411-2415.

  • Qanungo, S., Wang, M., and Nieminen, A.-L. (2004) N-Acetyl-L-cysteine enhances apoptosis through inhibition of NFkB in mouse embryonic fibroblasts. J Biol Chem. 279, 50455-50464

  • Morris, R.L., Azizuddin, K., Lam, M., Berlin, J., Nieminen, A.-L., Kenney, M.E., Samia, A.C.S., Burda, C., and Oleinick, N.L. (2003) Fluorescence Resonance Energy Transfer (FRET) between the cardiolipin probe nonyl-acridine orange and the photosensitizer Pc 4. Cancer Res. 63, 5194-5197.

  • Lam, M., Oleinick, N.L., and Nieminen, A.-L. (2001) Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells: Reactive oxygen species and mitochondrial inner membrane permeability. J. Biol. Chem. 276, 47379-47386.

The laboratory is investigating mechanisms of cell injury and cell death in various pathological settings, mostly related to cancer.  Currently we are interested in treating head and neck cancers with photodynamic therapy.