Luis J. Montaner, D.V.M., M.Sc., D.Phil.
Associate Professor, Immunology Program
The Wistar Institute
Dr. Luis Montaner obtained his D.V.M., Veterinary Medicine at Kansas State University in 1989, and his Ph.D. degree in Experimental Pathology at University of Oxford, Oxford, UK in 1995. His dissertation was entitled ÒCytokine Regulation of HIV-1 in Macrophages and Lymphocytes in vitroÓ .In 1995 became an Assistant Professor at The Wistar Institute, Philadelphia, PA and in 2007 was promoted to Professor in the same institute. He also holds a joint appointment with the Department of Medicine at the University of Pennsylvania Medical School. Department of Medicine. He lectures on the Immunology and Frontiers of Medicine courses at the University of Pennsylvania Medical School.
Dr. Montaner's group at the Wistar Institute is funded by RO1 grants from the NIH and other sources and his groups main research interests are the mechanisms of disease in HIV-1 infection and novel approaches to augment immune function by combining virological and immune-based research on patient-derived material as well as by using laboratory models of virus infection. The work is focused on 1) regulation of innate immunity, with emphasis on the effects of HIV infections and HAART on dendritic cells, macrophages, and Natural Killer cells 2) identifying new mechanisms of immunodeficiency, such as impaired IL-12 secretion, and discovering new approaches to reverse them through immunotherapy, 3) exploring new therapy management practices, such as structured therapy interruptions, and 4) understanding the relationship between immune antiviral responses and control of HIV-1 infection.
Dr. Montaner is a member of the Board of Directors of the Community-based AIDS Clinical Trials Group of the Philadelphia FIGHT (a community-based HIV-1 clinical research organization), a member of the Scientific advisory boards of Foundation for AIDS and Immune Research (FAIR), Los Angeles, CA and of Aventis-Pasteur, and an elected Councilor of the Society of Leukocyte Biology, FASEB (term 2006-2009)
Dr. Montaner is a south after national and international lecturer, and he has published in excess of 70 manuscripts in highly prestigious peer reviewed journals such as the Proceedings of the National Academy of Sciences Journal of Immunology, the Journal of Virology, the Journal of Infectious Diseases, Blood, and the Journal of Biological Chemistry.
Chehimi J., Campbell, D.E., Azzoni, L., Bacheller, D., E. Papasavvas, G Jerandi, G., Mounzer, K., Kostman, J.R., Trinchieri, G., and Montaner, L.J. 2002. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J. Immunol. 168:4796-801.
Papasavvas, E., Sanberg, J.K., Rutstein, R., Moore, E.C., Mackiewicz, A., Thiel, B., Pistilli, M., June, R.R., Jordan, K.A., Gross, R., Maino, V.C., Nixon, D.F., and Montaner, L.J. 2003. Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial viral suppression. J. Infect. Dis. 188:873-882.
Agadjanyan, M.G., Chattergoon, M.A., Holterman, M.J., Monzavi-Karbassi, B., Kim, J.J., Dentchev, T., Wilson, D., Ayyavoo, V., Montaner, L.J., Kieber-Emmons, T., Sekaly, R.-P., and Weiner, D.B. 2003. Co-stimulatory molecule immune enhancement in a plasmid vaccine model is regulated in part through the immunoglobulin constant-like domain of CD80/86. J. Immunol. 171:4311-4319.
Papasavvas, E., Grant, R.M., Sun, J., Mackiewicz, A., Pistilli, M., Gallo, C., Kostman, J.R., Mounzer, K., Shull, J., and Montaner, L.J. 2003. Lack of persistent drug-resistant mutations evaluated within and between treatment interruptions in chronically HIV infected patients. AIDS 17:2337-2343.
Azzoni, L., Papasavvas, E., and Montaner, L.J. 2003. Lessons Learned from HIV Treatment Interruption: Safety, Correlates of Immune Control, and Drug Sparing. Current HIV Research. 1: 329-342.
Collman, R.G., Perno, C.-F., Crowe, S., Stevenson, M., and Montaner, L.J. 2003. HIV and cells of macrophage/dendritic lineage and other non-T cell reservoirs: new answers yield new questions. J Leukocyte Biol. 74:631-634.
Chattergoon, M.A., Saulino, V., Shames, J.P., Stein, J., Montaner, L.J., Weiner, D.B. 2004. Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice. Vaccine. 22:1744-1750.
Luo, Q., Ma, X., Wahl, S.M., Bieker, J.J., Crossley, M., and Montaner, L.J. 2004. Activation and Repression of IL-12 p40 Transcription by Erythroid Kruppel-Like Factor (EKLF) in Macrophages. J Biol. Chem. 279: 18451-18456.
Papasavvas, E., Kostman, J.R., Mounzer, K., Grant, R.M., Gross, R., Gallo, C., Azzoni, L., Foulkes, A., Thiel, B., Pistilli, M., Mackiewicz, A., Shull, J., Montaner, L.J. 2004. Randomized Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection. PLoS Medicine 1:e64.
Wysocka, M., Benoit, B.M., Newton, S., Azzoni, A., Montaner, L.J., Rook, A.H. 2004. Enhancement of the host immune responses in cutaneous T cell lymphoma by CpG oligodeoxynucleotides and IL-15. Blood 104:4142-4149.
Azzoni, L., Rutstein, R., Chehimi, J., Farabaugh, M., Nowmos, A., Montaner, L.J. 2005. Dendritic and Natural Killer cell subsets associated with stable or declining CD4 cells in treated HIV-1 infected children. J. Infect. Dis. 191:1451-1459.
Papasavvas, E., Sun, J., Luo, Q., Moore, E.C. , Thiel, B., MacGregor, R.R., Minty, A., Mounzer, K., Kostman, J.R., and Montaner, L.J. 2005. IL-13 acutely augments HIV-specific and recall responses from HIV-1 infected subjects in vitro by modulating monocytes. J. Immunol. 15;175(8):5532-40.
Papasavvas, E., Kostman, J.R., Thiel, B., Pistilli, M., Mackiewicz, A., Foulkes, A., Gross, R., Jordan.. K.A., Nixon, D.F., Grant, R., Poulin, J.-F., McCune, J.M., Mounzer, K., Montaner, L.J. 2006. HIV-1-specific CD4 T cell responses and viral suppression in chronically HIV-1 infected blippers undergoing treatment interruption. J. Clin. Immunol. 26(1):40-54.
Giri, M, Nebozhyn, M., Showe, L., Montaner, L.J. 2006. Review of Microarray Data on Gene Modulation by HIV-1 in Immune Cells: 2000-2006. J. Leuko. Biol. 80(5)1031-1043.
Montaner, L.J., Crowe, S., Aquaro, S., Perno, C., Stevenson, M., Collman, R. 2006. Advances in macrophage and dendritic cell biology in HIV-1 infection stress key understudied areas in infection, pathogenesis and analysis of viral reservoirs. J. Leuko. Biol. 80(5)961-964.
Azzoni, L., Chehimi, J., Foulkes, A., Zhou, L., and Montaner, L.J. 2007. Early and Delayed Benefits of HIV-1 Suppression: Timeline of Recovery of Innate Immunity Effector Cells. AIDS. 21(3):293-305.
Tomescu, C., Chehimi, J., Maino, V.C., and Montaner, L.J. 2007. Natural Killer Cell Lysis of HIV-1+ Autologous CD4 Primary T cells: Requirement for Interferon-mediated NK activation by Plasmacytoid Dendritic Cells. J. Immunol. 179:2097-2104.
Chehimi, J., Azzoni, L., Farabaugh, M., Creer, S.A., Tomescu, C., Hancock, A., Mackiewicz, A., DÕAlessandro, L., Ghanekar, S., Foulkes, A., Mounzer, K., Kostman, J., and Montaner, L.J. 2007. Baseline viral load and immune activation determine the extent of reconstitution of innate immune effectors in HIV-1 infected subjects undergoing antiretroviral therapy. J. Immunol. 179:2642-2650.