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Department of biochemistry and Molecular biology

Faculty

Bastia Picture Bastia, Deepak, PhD
Professor
Gaylord and Dorothy Donnelley Chair in Biomedical Sciences
Analyses of (1) the mechanisms of initiation of DNA replication of prokaryotic plasmids and (2) the termination of DNA replication of plasmid, bacterial and yeast chromosomal, and human mitochondrial DNA.
               
 Erika Bullesbach Büllesbach, Erika, PhD
Associate Professor

Hormones of insulin-like structure; chemical syntheses and structure-function relations.

           
Julie Chao Chao, Julie, PhD
Professor

Serine proteinase structure-function relationship; purification, molecular cloning, expression, and function of proteinases and proteinase inhibitors; serpin regulation of gene expression.

           
Lee Chao Chao, Lee, PhD
Professor

Nucleic acid biochemistry; regulatory mechanism in gene expression; gene therapy in cardiovascular diseases.

           
Ashley Cowart Cowart, Ashley, PhD
Associate Professor

Regulation of sphingolipid synthesis in obesity, diabetes, and cardiovascular disease. Approaches used include microarrays, lipidomics, mouse models, tissue culture.

             
Christopher Davies Davies, Christopher, PhD
Professor
Director, Graduate Programs

Structural basis for antibiotic resistance in pathogenic bacteria and development of new antimicrobials.

               
J Alan Diehl 
Diehl, J. Alan
Professor
Endowed Professor of Lipidomics and Pathobiology
Regulation of cell division in normal and cancer cells with an emphasis on protein ubiquitylation and epigenetic regulation.  Characterization of signal transduction pathways and micro-RNAs that permit tumor cell survival and represent potential therapeutic targets.    
          
Daniel Fernandes Fernandes, Daniel, PhD
Professor Emeritus

Molecular mechanisms of drug-induced gene amplification. Interactions of anticancer drugs with nuclear matrix proteins, especially DNA topoisomerase II.

                 
Vamsi Gangaraju, PhD 
Gangaraju, Vamsi, PhD
Assistant Professor
Epigenetic regulation by Piwi-piRNA pathway; biogenesis and biological functions of piRNAs; environmental epigenetics; drosophila models of human diseases.
              
Heise Picture 
Heise, Tilman, PhD
Assistant Professor
RNA-binding proteins regulating the posttranscriptional control of gene expression. Our work is centered on the functional analysis of aberrant expressed RNA-binding proteins in cancer pathogenesis.
          
Hennig Picture 
Hennig, Mirko, PhD
Associate Professor
Structural studies of RNA-ligand complexes using NMR spectroscopy.
         
Philip Howe, PhD Howe, Philip H., PhD
Professor and Chairman
Hans and Helen Koebig Chair in Clinical Oncology

Signaling pathways activated by transforming growth factor β1 (TGFβ1) and Wnt and their potential cross-talk in cellular models of differentiation and cancer.

       
Hsu Picture Hsu, Yi-Te, PhD
Associate Professor

Molecular mechanisms of apoptosis Bcl-2, Bcl-XL.
          
Lemasters Picture Lemasters, John, MD, PhD
Professor

Cellular and molecular mechanisms of apoptosis and necrosis; organ preservation for transplantation surgery; mitochondrial physiology and pathophysiology, including mitochondrial permeability transition, mitophagy and calcium homeostasis; oxidative stress; ischemia/reperfusion; confocal and multiphoton microscopy of living cells.
          
David Long, PhD 
Long, David T., PhD
Assistant Professor
 
The mechanistic role of BRCA1 in DNA repair and cancer predisposition.
           
Shaun Olsen, PhD Olsen, Shaun, PhD
Assistant Professor

Structural basis by which ubiquitin is specifically conjugated to target proteins and for how ubiquitination acts as a molecular switch that regulates growth factor signaling pathways.

          
Besim Ogretmen, PhD Ogretmen, Besim, PhD
Professor and Eminent Scholar

Roles of sphingolipid metabolism in cancer pathogenesis, chemotherapy-induced cell death, and drug resistance.
               
Schwabe Picture Schwabe, Christian, PhD, DDS
Professor
Protein chemistry; biochemical evolution; chemical endocrinology.
                   
 Sommer, Gunhild, PhD
Assistant Professor

The role of RNA-binding proteins in cancer.
          
 Spicer, Eleanor, PhD
Professor Emeritus
Post transcriptional regulation of Bcl-2 gene expression; regulation of human oncostatin M expression; mRNA stability.
           
Yong-Mei Zhang Zhang, Yong-Mei, PhD
Assistant Professor

Bacterial quorum sensing network; Pseudomonas aeruginosa motility; structures and functions of essential enzymes of bacterial pathogens.
           
Research Faculty
Aiping Bai Bai, Aiping, PhD
Research Assistant Professor

Medicinal chemistry; computer-aided molecular design; enzyme inhibitors R&D; bioactive sphingolipids synthesis.
            
Ala Bielawska Bielawska, Alicja, PhD
Research Professor

Role of sphingolipids in signal transduction and cell regulation with emphasis on cancer biology. Specific interest is related to the regulatory function of ceramide and sphingosine-1-phosphate.  Development of molecular and analytical tools to study mechanism of biological action of sphingolipids in relation to their physicochemical properties.
                
Jacek Bielawski, PhD Bielawski, Jacek, PhD
Research Professor

Sphingolipids in signal transduction; cell regulation in cancer biology; development of new analytical protocols.
            
Alena Fedarovich Fedarovich, Alena, PhD
Research Assistant Professor

Structural and biochemical characterization of the proteins using X-ray crystallography, circular dichroism, dynamic light scattering, fluorescent spectroscopy; Protein-protein and protein-ligand interactions; Development and application of the High-throughput screening assay of the inhibitors targeting transpeptidases for a rational drug design against pathogenic bacteria.
             
Daniella Ishimura Ishimaru, Daniella, PhD
Research Assistant Professor
           
Yong Jiang, PhD Yong Jiang, PhD
Research Assistant Professor
        
Bidyut Mohanty Mohanty, Bidyut K., PhD
Research Assistant Professor

Genome integrity; DNA replication arrest-dependent homologous recombination.
              
Natalia Olenik Oleinik, Natalia, PhD
Research Assistant Professor
           
song Picture Song, Jin Hyang, PhD
Research Assistant Professor
                  
Noel Warfel, PhD Noel Warfel, PhD
Research Assistant Professor
             
Szulc Picture Szulc, Zdzislaw, PhD
Research Associate Professor


Chemical etiology of sphingolipids structure and functions.
   

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