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Department of biochemistry and Molecular biology


Bastia PictureBastia, Deepak, PhD
Gaylord and Dorothy Donnelley Chair in Biomedical Sciences
Analyses of (1) the mechanisms of initiation of DNA replication of prokaryotic plasmids and (2) the termination of DNA replication of plasmid, bacterial and yeast chromosomal, and human mitochondrial DNA.
Erika BullesbachBüllesbach, Erika, PhD
Associate Professor

Hormones of insulin-like structure; chemical syntheses and structure-function relations.

Julie ChaoChao, Julie, PhD

Serine proteinase structure-function relationship; purification, molecular cloning, expression, and function of proteinases and proteinase inhibitors; serpin regulation of gene expression.

Lee ChaoChao, Lee, PhD

Nucleic acid biochemistry; regulatory mechanism in gene expression; gene therapy in cardiovascular diseases.

Ashley CowartCowart, Ashley, PhD
Associate Professor

Regulation of sphingolipid synthesis in obesity, diabetes, and cardiovascular disease. Approaches used include microarrays, lipidomics, mouse models, tissue culture.

Christopher Davies, PhDDavies, Christopher, PhD

Structural basis for antibiotic resistance in pathogenic bacteria and development of new antimicrobials.

J Alan Diehl
Diehl, J. Alan, PhD
Endowed Professor of Lipidomics and Pathobiology
Regulation of cell division in normal and cancer cells with an emphasis on protein ubiquitylation and epigenetic regulation.  Characterization of signal transduction pathways and micro-RNAs that permit tumor cell survival and represent potential therapeutic targets.    
Raymond DuBois

DuBois, Raymond, MD, PhD
Professor and Dean of Medicine

The molecular, genetic, and cellular basis for colorectal cancer.

Vamsi Gangaraju, PhD
Gangaraju, Vamsi, PhD
Assistant Professor
Epigenetic regulation by Piwi-piRNA pathway; biogenesis and biological functions of piRNAs; environmental epigenetics; drosophila models of human diseases.
Heise Picture
Heise, Tilman, PhD
Assistant Professor
RNA-binding proteins regulating the posttranscriptional control of gene expression. Our work is centered on the functional analysis of aberrant expressed RNA-binding proteins in cancer pathogenesis.
Philip Howe, PhDHowe, Philip H., PhD
Professor and Chairman
Hans and Helen Koebig Chair in Clinical Oncology

Signaling pathways activated by transforming growth factor β1 (TGFβ1) and Wnt and their potential cross-talk in cellular models of differentiation and cancer.

Hsu PictureHsu, Yi-Te, PhD
Associate Professor

Molecular mechanisms of apoptosis Bcl-2, Bcl-XL.
Lemasters PictureLemasters, John, MD, PhD

Cellular and molecular mechanisms of apoptosis and necrosis; organ preservation for transplantation surgery; mitochondrial physiology and pathophysiology, including mitochondrial permeability transition, mitophagy and calcium homeostasis; oxidative stress; ischemia/reperfusion; confocal and multiphoton microscopy of living cells.
David Long, PhD
Long, David T., PhD
Assistant Professor
Graduate Program Director
The mechanistic role of BRCA1 in DNA repair and cancer predisposition.
Shaun Olsen, PhDOlsen, Shaun, PhD
Assistant Professor

Structural basis by which ubiquitin is specifically conjugated to target proteins and for how ubiquitination acts as a molecular switch that regulates growth factor signaling pathways.

Besim Ogretmen, PhDOgretmen, Besim, PhD
Professor and Eminent Scholar

Roles of sphingolipid metabolism in cancer pathogenesis, chemotherapy-induced cell death, and drug resistance.
Visu Palanisamy, PhD
Visu (Viswanathan) Palanisamy
Associate Professor

Post-transcriptional gene regulation in head and neck cancer: Role of RNA-binding proteins, miRNAs and lncRNAs.

Schwabe PictureSchwabe, Christian, PhD, DDS
Protein chemistry; biochemical evolution; chemical endocrinology.
Sommer, Gunhild, PhD
Assistant Professor

The role of RNA-binding proteins in cancer.
Paula Traktman, PhD
Traktman, Paula PhD
Hirschmann Endowed Professor
Dean, College of Graduate Studies

Vaccinia virus genome replication and virion morphogenesis.  The role(s) of the cellular VRK1 protein kinase and BANF1 protein in normal cell function and cancer.

Je-Hyun Yoon, PhD
Yoon, Je-Hyun, PhD
Assistant Professor

Regulatory noncoding RNAs in aging and cancer.

Research Faculty
Aiping BaiBai, Aiping, PhD
Research Assistant Professor

Medicinal chemistry; computer-aided molecular design; enzyme inhibitors R&D; bioactive sphingolipids synthesis.
Yong Jiang, PhDJiang, Yong, PhD
Research Assistant Professor
Bidyut MohantyMohanty, Bidyut K., PhD
Research Assistant Professor

Genome integrity; DNA replication arrest-dependent homologous recombination.
Natalia OlenikOleinik, Natalia, PhD
Research Assistant Professor
Dariusz Pytel, PhD
Pytel, Dariusz PhD
Research Assistant Professor

The role of the PKR-like ER kinase (PERK) in the regulation of tumor growth and proliferation.

Baby Tholanikunnel, PhDTholanikunnel, Baby, PhD
Research Associate Professor
Szulc PictureSzulc, Zdzislaw, PhD
Research Associate Professor

Chemical etiology of sphingolipids structure and functions.
Emeritus Faculty
Dan Fernandes, PhDFernandes, Daniel, PhD
Professor Emeritus

Molecular mechanisms of drug-induced gene amplification. Interactions of anticancer drugs with nuclear matrix proteins, especially DNA topoisomerase II.

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