Department of biochemistry and Molecular biology

Aiping Bai, PhD

Research Assistant ProfessorAiping Bai, PhD
Biochemistry and Molecular Biology

Education
2001 - PhD, Peking Union Medical College, CHINA

Contact Info
Email: baia@musc.edu
Office: 843-792-8853
Lab: 843-792-8853
BSB-748

Research Interests

Current research mainly focus on acid ceramidase (ACDase), a lysosomal enzyme, causes degradation of Ceramide (Cer) into sphingosine (Sph) and free fatty acids at pH optimum 4.5. ACDase represents a new target for cancer therapy because of its importance in regulating the Cer–Sph–S1P inter-metabolism. Elevation of ACDase was shown in many tumor tissues when compared with patient’s matched normal ones. ACDase can also be over-expressed in prostate cancer cells after a single, low-dose of ionizing radiation, raising speculation about the correlation of increased ACDase to radio-resistance, and the potential of ACDase inhibition being a therapeutic strategy for treating cancer.

Recent Publications

1. Separovic D, Joseph N, Breen P, Bielawski J, Pierce JS, Buren EV, Bhatti G, Saad ZH, Bai A, Bielawska A. Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization. Biochem Biophys Res Commun. 2011 Jun 10;409(3):372-7.

2. Szulc ZM, Bai A, Bielawski J, Mayroo N, Miller DE, Gracz H, Hannun YA, Bielawska A. Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorg Med Chem. 2010 Nov 1;18(21):7565-79. Epub 2010 Sep 28.

3. Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Synthesis and bioevaluation of omega-N-amino analogs of B13. Bioorg Med Chem. 2009 Mar 1;17(5):1840-8.

4. Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther. 2009 Mar;17(3):430-8.

5. Bielawska A, Bielawski J, Szulc ZM, Mayroo N, Liu X, Bai A, Elojeimy S, Rembiesa B, Pierce J, Norris JS, Hannun YA. Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.  Bioorg Med Chem. 2008 Jan 15;16(2):1032-45.

6. Szulc ZM, Mayroo N, Bai A, Bielawski J, Liu X, Norris JS, Hannun YA, Bielawska A. Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. Bioorg Med Chem. 2008 Jan 15;16(2):1015-31.

7. Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, Turner LS, Cheng J, Bielawska A, Bielawski J, Keane TE, Obeid LM, Hannun YA, Norris JS, Liu X. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther. 2007 Sep;6(9):1455-60.

8. Probin V, Wang Y, Bai A, Zhou D. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism. J Pharmacol Exp Ther. 2006 Nov;319(2):551-60.

9. Bai A, Meier GP, Wang Y, Luberto C, Hannun YA, Zhou D. Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther. 2004 Jun;309(3):1051-9.

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