Department of biochemistry and Molecular biology
Aiping Bai, PhD
Research Assistant Professor
Biochemistry and Molecular Biology
2001 - PhD, Peking Union Medical College, CHINA
Current research mainly focus on acid ceramidase (ACDase), a lysosomal enzyme, causes degradation of Ceramide (Cer) into sphingosine (Sph) and free fatty acids at pH optimum 4.5. ACDase represents a new target for cancer therapy because of its importance in regulating the Cer–Sph–S1P inter-metabolism. Elevation of ACDase was shown in many tumor tissues when compared with patient’s matched normal ones. ACDase can also be over-expressed in prostate cancer cells after a single, low-dose of ionizing radiation, raising speculation about the correlation of increased ACDase to radio-resistance, and the potential of ACDase inhibition being a therapeutic strategy for treating cancer.
Cheng JC, Bai A, Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR Jr, Bielawska A, Norris JS, Liu X. Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse. J Clin Invest. 2013, Oct1; 123(10):4344-58. PMID: 24091326
Szulc ZM, Bai A, Bielawski J, Mayroo N, Miller DE, Gracz H, Hannun YA, Bielawska A. Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorg Med Chem. 2010 Nov 1;18(21):7565-79. Epub 2010 Sep 28.
Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Synthesis and bioevaluation of omega-N-amino analogs of B13. Bioorg Med hem. 2009 Mar 1;17(5):1840-8.