Deepak Bastia, Ph.D.
Professor
Biochemistry and Molecular Biology
Gaylord and Dorothy Donnelley Chair in Biomedical sciences

1985-2001     Professor, Duke University Medical Center, Durham, NC
1979-1985     Associate Professor, Duke University Medical Center, Durham, NC
1977-1979     Assistant Professor, UAB, Birmingham, AL
1974-1977     Postdoctoral Fellow, Yale University, New Haven, CT
1972-1974     Postdoctoral Fellow, University of Colorado, Boulder, CO
1971-1972     Postdoctoral Fellow, Princeton University, Princeton, NJ

Education
1971         Ph.D., University of Chicago, Chicago, IL
1965         M.S., IARI, New Delhi, India

Contact Info
Email: bastia@musc.edu
Office: 843-792-0491
Lab: 843-792-0281
Fax: 843-792-8568
BSB-518A

Research Interests

The primary focus of our laboratory is on the investigations of the molecular mechanisms of replication fork arrest, genome stability, checkpoint controls using Saccharomyces cerevisiae and Schizosaccharomyces pombe as model systems. These are topics of intense current interest not only from the perspectives of eukaryotic DNA transactions but also of Cancer Biology. Our laboratory is also interested in the molecular analysis of the human “timeless” protein and TIPIN (timeless-interacting protein).

Our laboratory offers outstanding training in nucleic acids biochemistry, enzymology of DNA replication and on protein nucleic acids and protein-protein interactions.

Recent Publications | Additional Publications

1. Singh S., Sabatinos S., Forsburg S. and Bastia D. (2010) Regulation of replication termination by Reb1 protein-mediated action at a distance. Cell 142:868-878.

2. Swan M., Bastia D. and Davies C. (2006) Crystal structure of pi initiator protein-iteron complex of plasmid R6K: implications for initiation of plasmid DNA replication. Proc. Natl. Acad. Sci. USA 103:18481-18486.

3. Krings G. and Bastia D. (2006) Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex. Mol. Cell. Biol. 26:8061-8074.

4. Bastia D., Zzaman S., Krings G., Saxena M., Peng X. and Greenberg M.M. (2008) Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase. Proc. Natl. Acad. Sci USA 105:12831-12836.

5. Biswas S. and Bastia D. (2008) Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of S. pombe. Mol. Cell. Biol. 28:6844-6857.

6. Mohanty B.K., Bairwa N.K. and Bastia D. (2009) Contrasting roles of checkpoint proteins as recombination modulators at Fob1-Ter complexes with or without fork arrest. Eukaryot Cell. 8(4):487-95. Epub 2009 Feb 20. PubMed PMID: 19234097; PubMed Central PMCID: PMC2669202.

7. Bastia D. and Singh S. (2011) Chromosome kissing and modulation of replication termination. Bioarchitect. (in press).

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