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Department of biochemistry and Molecular biology

Faculty

Bastia PictureBastia, Deepak, PhD
Professor
Gaylord and Dorothy Donnelley Chair in Biomedical Sciences
Analyses of (1) the mechanisms of initiation of DNA replication of prokaryotic plasmids and (2) the termination of DNA replication of plasmid, bacterial and yeast chromosomal, and human mitochondrial DNA.
              
 Erika BullesbachBüllesbach, Erika, PhD
Associate Professor

Hormones of Insulin-Like Structure:
Chemical Syntheses and Structure-Function Relations

         
Julie ChaoChao, Julie, PhD
Professor

Serine Proteinase Structure-Function Relationship;
Purification, Molecular Cloning, Expression, and Function of Proteinases and Proteinase Inhibitors;
Serpin Regulation of Gene Expression

         
Lee ChaoChao, Lee, PhD
Professor

Nucleic Acid Biochemistry;
Regulatory Mechanism in Gene Expression;
Gene Therapy in Cardiovascular Diseases

         
Ashley CowartCowart, Ashley, PhD
Assistant Professor

Regulation of sphingolipid synthesis in obesity, diabetes, and cardiovascular disease.
Approaches used include microarrays, lipidomics, mouse models, tissue culture.

           
Christopher DaviesDavies, Christopher, PhD
Professor
Director, Graduate Programs

Structural basis for antibiotic resistance in pathogenic bacteria and development of new antimicrobials.

         
Daniel FernandesFernandes, Daniel, PhD
Professor

Molecular mechanisms of drug-induced gene amplification;
Interactions of anticancer drugs with nuclear matrix proteins, especially DNA topoisomerase II.

               
Vamsi Gangaraju, PhD

Gangaraju, Vamsi, PhD
Assistant Professor

Epigenetic regulation by Piwi-piRNA pathway, Biogenesis and biological functions of piRNAs, Environmental Epigenetics, Drosophila models of human diseases.

          
Hama, Hiroko, PhD
Associate Professor

Role of FA2H in myelination and glial cell signaling;
Role of hydroxy sphingolipids in cell differentiation;
Development of lipid therapeutics for FA2H deficiency.
                
Heise Picture

Heise, Tilman, PhD
Assistant Professor

RNA-binding proteins regulating the posttranscriptional control of gene expression. Our work is centered on the functional analysis of aberrant expressed RNA-binding proteins in cancer pathogenesis.

        
Hennig Picture

Hennig, Mirko, PhD
Associate Professor

Structural Studies of RNA-ligand complexes using NMR Spectroscopy

       
Philip Howe, PhD Howe, Philip H., PhD
Professor and Chairman
Hans and Helen Koebig Chair in Clinical Oncology

Signaling pathways activated by transforming growth factor β1 (TGFβ1) and Wnt and their potential cross-talk in cellular models of differentiation and cancer.

     
Hsu Picture
Hsu, Yi-Te, PhD
Associate Professor

Molecular mechanisms of apoptosis Bcl-2, Bcl-XL.
      
Krupenkn Picture
Krupenko, Natalia, PhD
Assistant Professor

Folate and Methyl Group Metabolism
Glycine N-Methyltransferase (GNMT)
       
Krupenko Picture
Krupenko, Sergey, PhD
Professor

Protein Structure and Function
Enzyme Mechanisms and Regulation
Folate Metabolism and Carcinogenesis
         
Lemasters Picture
Lemasters, John , MD, PhD
Professor

Cellular and molecular mechanisms of apoptosis and necrosis;
organ preservation for transplantation surgery;
mitochondrial physiology and pathophysiology, including mitochondrial permeability transition, mitophagy and calcium homeostasis;
oxidative stress;
ischemia/reperfusion; confocal and multiphoton microscopy of living cells.
        
Shaun Olsen, PhDOlsen, Shaun, PhD
Assistant Professor

Structural basis by which ubiquitin is specifically conjugated to target proteins and for how ubiquitination acts as a molecular switch that regulates growth factor signaling pathways.

        
Besim Ogretmen, PhD
Ogretmen, Besim, PhD
Professor and Eminent Scholar

Roles of sphingolipid metabolism in cancer pathogenesis, chemotherapy-induced cell death, and drug resistance.
             
Schwabe Picture
Schwabe, Christian, PhD, DDS
Professor

Protein Chemistry
Biochemical Evolution
Chemical Endocrinology
                 
Sommer, Gunhild, PhD
Assistant Professor

The Role of RNA-binding Proteins in Cancer
        
Spicer, Eleanor, PhD
Professor

Post Transcriptional Regulation of Bcl-2 Gene Expression;
Regulation of human oncostatin M expression;
mRNA stability.
         
Yong-Mei ZhangZhang, Yong-Mei, PhD
Assistant Professor

Bacterial quorum sensing network;
Pseudomonas aeruginosa motility;
Structures and functions of essential enzymes of bacterial pathogens.
         
Research Faculty
Aiping Bai
Bai, Aiping, PhD
Research Assistant Professor

Medicinal Chemistry, Computer-Aided Molecular Design; Enzyme inhibitors R&D; Bioactive Sphingolipids synthesis.
          
Ala BielawskaBielawska, Alicja, PhD
Research Professor

Role of sphingolipids in signal transduction and cell regulation with emphasis on cancer biology. Specific interest is related to the regulatory function of ceramide and sphingosine-1-phosphate.
Development of molecular and analytical tools to study mechanism of biological action of sphingolipids in relation to their physicochemical properties.
              
Jacek Bielawski, PhDBielawski, Jacek, PhD
Research Professor

Sphingolipids in Signal Transduction
Cell Regulation in Cancer Biology
Development of new analytical protocols
          
Alena FedarovichFedarovich, Alena, PhD
Research Assistant Professor

Structural and biochemical characterization of the proteins using X-ray crystallography, circular dichroism, dynamic light scattering, fluorescent spectroscopy;
Protein-protein and protein-ligand interactions;
Development and application of the High-throughput screening assay of the inhibitors targeting transpeptidases for a rational drug design against pathogenic bacteria.
           
Daniella IshimuraIshimaru, Daniella, PhD
Research Assistant Professor
         
Yong Jiang, PhDYong Jiang, PhD
Research Assistant Professor
      
Bidyut MohantyMohanty, Bidyut K., PhD
Research Assistant Professor

Genome integrity;
DNA replication arrest-dependent homologous recombination.
            
Natalia OlenikOleinik, Natalia, PhD
Research Assistant Professor
         
song PictureSong, Jin Hyang, PhD
Research Assistant Professor
                
Noel Warfel, PhDNoel Warfel, PhD
Research Assistant Professor
           
Szulc PictureSzulc, Zdzislaw, PhD
Research Associate Professor


Chemical etiology of sphingolipids structure and functions.

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