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Department of biochemistry and Molecular biology

Besim Ogretmen, PhD

Professor and Eminent ScholarBesim Ogretmen, PhD
Biochemistry and Molecular Biology

Education
1989-1994  PhD, Biology, Illinois Institute of Technology, Chicago, IL
1994-1996  Post-doctoral Fellow, Section of Hematology/Oncology, The University of Chicago

Contact Info
Email: ogretmen@musc.edu
Office: HCC-512A /843-792-0940
Lab: HCC-509 / 843-792-0941

86 Jonathan Lucas Street
Hollings Cancer Center, Charleston, SC 29425

Research Interests

  • Molecular mechanisms of the regulation of telomerase and telomeres by ceramide signaling.
  • Mechanisms of ceramide-mediated regulation of PP2A by lipid-protein interactions.
  • Regulation of ER stress and apoptosis by sphingolipid metabolism.
  • Mechanisms of lipid-regulated cancer metastasis and drug resistance.
  • Mechanisms of autophagy and necroptosis-mediated cancer cell death pathways by lipid signaling.

Recent Publications | Additional Publications

Thomas RJ, Oleinik N, Panneer Selvam S, Vaena SG, Dany M, Nganga RN, Depalma RM, Baron KD, Kim J, Szulc ZM, Ogretmen B. (2017) HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med Jun 12. pii: e201607088. doi: 10.15252/emmm.201607088.

Lv Z, Rickman KA, Yuan L, Williams K, Selvam SP, Woosley AN, Howe, PH, Ogretmen B, Smogorzewska A, Olsen SK. (2017) S. pombe Uba1-Ubc15 structure reveals a novel regulatory mechanism of ubiquitin E2 activity. Molecular Cell 65(4):699-714.

Dany M, Gencer S, Nganga R, Thomas RJ, Oleinik N, Baron KD, Szulc ZM, Ruvolo P, Kornblau S, Andreeff M, Ogretmen B. (2016) Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML. Blood 128(15):1944-1958.

Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. (2015) Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylationScience Signaling 8(381):ra58. 

Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Panneer Selvam S, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, and Ogretmen B. (2012) Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chem Biol 8(10):831-8.

Recent collaborations
Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ. (2017) Ceramide synthesis regulates T cell activity and GVHD development. JCI Insight 2(10). pii: 91701. doi: 10.1172/jci.insight.91701.

Britten CD, Garrett-Mayer E, Chin SH, Shirai K, Ogretmen B, Bentz TA, Brisendine A, Anderton K, Cusack SL, Maines LW, Zhuang Y, Smith CD, Thomas MB. (2017) A phase I study of ABC294640, a first-in-class sphingosine kinase-2 inhibitor, in patients with advanced solid tumors. Clin Cancer Res Apr 18. doi: 10.1158/1078-0432.CCR-16-2363.

Lv Z, Rickman KA, Yuan L, Williams K, Selvam SP, Woosley AN, Howe PH, Ogretmen B, Smogorzewska A, Olsen SK. (2017) S. pombe Uba1-Ubc15 structure reveals a novel regulatory mechanism of ubiquitin E2 activity. Mol Cell 65(4):699-714.e6. doi: 10.1016/j.molcel.2017.01.008.

Fekry B, Jeffries KA, Esmaeilniakooshkghazi A, Ogretmen B, Krupenko SA, Krupenko NI. (2016) CerS6 is a novel transcriptional target of p53 protein activated by non-genotoxic stress. J Biol Chem 291(32):16586-96. doi: 10.1074/jbc.M116.716902. 

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