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Department of biochemistry and Molecular biology

Besim Ogretmen, PhD

Professor and Eminent ScholarBesim Ogretmen, PhD
Biochemistry and Molecular Biology

1989-1994  PhD, Biology, Illinois Institute of Technology, Chicago, IL
1994-1996  Post-doctoral Fellow, Section of Hematology/Oncology, The University of Chicago

Contact Info
Office: HCC-512A /843-792-0940
Lab: HCC-509 / 843-792-0941

86 Jonathan Lucas Street
Hollings Cancer Center, Charleston, SC 29425

Research Interests

  • Molecular mechanisms of the regulation of telomerase and telomeres by ceramide signaling.
  • Mechanisms of ceramide-mediated regulation of PP2A by lipid-protein interactions.
  • Regulation of ER stress and apoptosis by sphingolipid metabolism.
  • Mechanisms of lipid-regulated cancer metastasis and drug resistance.
  • Mechanisms of autophagy and necroptosis-mediated cancer cell death pathways by lipid signaling.

Recent Publications | Additional Publications

Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. (2015) Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylationScience Signaling 8(381):ra58. 

Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, and Ogretmen B. (2012) Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumor suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med 5(1):105-21.

Sentelle, RD, Senkal, CE, Jiang, W, Ponnusamy, S, Gencer, S, Panneer Selvam, S, Ramshesh, VK, Peterson, YK, Lemasters, JJ, Szulc, ZM, Bielawski, J, and Ogretmen, B. (2012) Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chem Biol 8(10):831-8.

Meyers-Needham M, Ponnusam S, Gencer S, Jiang W, Thomas, RJ, Senkal CE, and Ogretmen B. (2012) Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. EMBO Mol Med 4(2):78-92.

Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. (2012) Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther 11(5):1092-102.

Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B. (2012) Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med 4(8):761-75.

Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B. (2011) Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood 117(22):5941-52. PMC3112039

Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. (2011) Alteration of ceramide Synthase 6/C16-ceramide induces activating transcription factor 6-mediated ER-stress and apoptosis via perturbation of cellular Ca+2 and ER/Golgi membrane network. J Biol Chem 286(49):42446-58. PMC3234959

Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. (2011) Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res 17(18):6097-105. PMC3176980

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