Department of biochemistry and Molecular biology
Besim Ogretmen, PhD
1994-1996 Post-doctoral Fellow, Section of Hematology/Oncology,
The University of Chicago
86 Jonathan Lucas Street
Hollings Cancer Center, Charleston, SC 29425
HCC-512A ( office)
- Molecular mechanisms of the regulation of telomerase and telomeres by ceramide signaling.
- Mechanisms of ceramide-mediated regulation of PP2A by lipid-protein interactions.
- Regulation of ER stress and apoptosis by sphingolipid metabolism.
- Mechanisms of lipid-regulated cancer metastasis and drug resistance.
- Mechanisms of autophagy and necroptosis-mediated cancer cell death pathways by lipid signaling.
Recent Publications | Additional Publications
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, and Ogretmen B. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumor suppression via activation of PP2A-RIPK1-dependent necroptosis. EMBO Mol Med. 2012, in press.
Sentelle, RD, Senkal, CE, Jiang, W, Ponnusamy, S, Gencer, S, Panneer Selvam, S, Ramshesh, VK, Peterson, YK, Lemasters, JJ, Szulc, ZM, Bielawski, J, and Ogretmen, B. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chem Biol. 2012, in press.
Meyers-Needham M, Ponnusam S, Gencer S, Jiang W, Thomas, RJ, Senkal CE, and Ogretmen B. Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. EMBO Mol Med. 2012; 4(2):78-92.
Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012; 11(5):1092-102.
Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med. 2012; 4(8):761-75.
Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 2011;117(22):5941-52 (PMC3112039).
Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide Synthase 6/C16-ceramide induces activating transcription factor 6-mediated ER-stress and apoptosis via perturbation of cellular Ca+2 and ER/Golgi membrane network. J Biol Chem. 2011; 286(49):42446-58 (PMC3234959).
Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, Ogretmen B. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011; 17(18):6097-105 (PMC3176980).