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Department of biochemistry and Molecular biology

Natalia Oleinik, PhD

Research Assistant ProfessorNatalia Oleinik, PhD
Biochemistry and Molecular Biology

2000-2007 - Postdoctoral Fellow, MUSC

1991 - Ph.D., Moscow State University, Moscow, Russia

Contact Info
Office: 843-792-0941

Research Interests

Currently my research  focuses  on  understanding of the molecular mechanisms connecting folate pathways and cellular motility. Recently, we have demonstrated that folate stress (disruption of folate metabolic pathways)  inhibits migration and invasion of cancer cells by a mechanism independent from its function in apoptosis. These findings support the hypothesis of the existence of a distinct pathway linking motility and folate status. Therefore, the elucidation of the mechanisms by which folates contribute to the control of motility mechanisms in the cell could provide novel targets for anticancer therapy.

Recent Publications | Additional Publications

Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA. (2011) Activation of p21-dependent G1/G2 arrest in the absence of DNA damage as an antiapoptotic response to metabolic stress. Genes Cancer 2(9):889-99. PMID: 22593801

Oleinik NV, Krupenko NI, Krupenko SA. (2011) Epigenetic silencing of ALDH1L1, a metabolic regulator of cellular proliferation in cancers. Genes Cancer 2(2):130-9. PMID: 21779486

Strickland KC, Holmes RS, Oleinik NV, Krupenko NI, Krupenko SA. (2011) Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes. Chem Biol Interact 191(1-3):122-8. PMID: 21215736

Oleinik NV, Krupenko NI, Krupenko SA. (2010) ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. Oncogene 29(47):6233-44. PMID: 20729910

Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. (2010) ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. J Biol Chem 285(30):23056-63. PMID: 20498374

Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA. (2010) Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. J Biol Chem 285(3):1627-33. PMID: 19933275

Ghose S, Oleinik NV, Krupenko NI, Krupenko SA. (2009) 10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status. Mol Cancer Res 7(1):99-107. PMID: 19147541

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