Department of biochemistry and Molecular biology
Natalia Oleinik, PhD
2000-2007 - Postdoctoral Fellow, MUSC
1991 - Ph.D., Moscow State University, Moscow, Russia
Currently my research focuses on understanding of the molecular mechanisms connecting folate pathways and cellular motility. Recently, we have demonstrated that folate stress (disruption of folate metabolic pathways) inhibits migration and invasion of cancer cells by a mechanism independent from its function in apoptosis. These findings support the hypothesis of the existence of a distinct pathway linking motility and folate status. Therefore, the elucidation of the mechanisms by which folates contribute to the control of motility mechanisms in the cell could provide novel targets for anticancer therapy.
Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA. Activation of p21-dependent G1/G2 arrest in the absence of DNA damage as an antiapoptotic response to metabolic stress. Genes Cancer. 2011 Sep;2(9):889-99. PubMed PMID: 22593801; PubMed Central PMCID: PMC3352155.
Oleinik NV, Krupenko NI, Krupenko SA. Epigenetic silencing of ALDH1L1, a metabolic regulator of cellular proliferation in cancers. Genes Cancer. 2011 Feb;2(2):130-9. PubMed PMID: 21779486; PubMed Central PMCID: PMC3111244.
Strickland KC, Holmes RS, Oleinik NV, Krupenko NI, Krupenko SA. Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes. Chem Biol Interact. 2011 May 30;191(1-3):122-8. Epub 2011 Jan 6. PubMed PMID: 21215736; PubMed Central PMCID: PMC3103616.
Oleinik NV, Krupenko NI, Krupenko SA. ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. Oncogene. 2010 Nov 25;29(47):6233-44. Epub 2010 Aug 23. PubMed PMID: 20729910; PubMed Central PMCID: PMC2992098.
Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 2010 May 24. [Epub ahead of print] PubMed PMID: 20498374.
Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA. Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 2010 Jan 15;285(3):1627-33. Epub 2009 Nov 20. PubMed PMID: 19933275; PubMed Central PMCID: PMC2804320.
Ghose S, Oleinik NV, Krupenko NI, Krupenko SA. 10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status. Mol Cancer Res. 2009 Jan;7(1):99-107. PubMed PMID: 19147541; PubMed Central PMCID: PMC2632845.