Skip Navigation
 

Department of biochemistry and Molecular biology

Shaun Olsen, PhD

Assistant ProfessorShaun Olsen, PhD
Biochemistry and Molecular Biology

2013-present Assistant Professor, Medical University of South Carolina, Charleston, SC
2008-2013 Postdoctoral Fellow, Sloan-Kettering Institute, New York, NY
2006-2008 Research Associate, RIKEN Genomic Sciences Center, Yokohama, Japan

Education
2006    PhD,  New York University, New York, NY
2000    BA, Rutgers University, New Brunswick, NJ
         

Contact Info
Email:
olsensk@musc.edu
Office (DDB-206): 843-876-2308
Lab (DDB-220): 843-876-2310

Research Interests

Post-translational modification of proteins by ubiquitin and ubiquitin-like modifiers (collectively termed Ubls) is a means of regulating fundamental cellular processes such as cell cycle control, signal transduction, and differentiation. Ubiquitin conjugation proceeds through the sequential activities of three enzymes (E1, E2, and E3) and alters target protein properties such as activity/conformation, subcellular localization, stability, and capacity for intermolecular interactions, ultimately accounting for the cellular response. The lab aims to understand the molecular mechanisms by which ubiquitin proceeds through its enzymatic cascade and is ultimately conjugated to target proteins in a specific and regulated manner. In addition to its role in maintaining homeostasis, the ubiquitin pathway is implicated in a number of human pathologies including cancer and neurodegenerative disorders and we frame our studies around proteins that when dysregulated are implicated in these disorders. To achieve these goals, we employ a multidisciplinary approach that includes X-ray crystallography complemented with biochemical/biophysical techniques and yeast genetics.

Recent Publications | Additional Publications

Olsen SK, Lima CD. Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer. Molecular Cell 2013 Mar 7;49(5):884:96.

Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodeling accompanies thioester bond formation in SUMO E1. Nature 2010 Feb 18;463(7283):906-12.

Lu X, Olsen SK, Capili AD, Cisar JS, Lima CD, Tan DS. Designed semisynthetic inhibitors of Ub/Ubl E1 activating enzymes. J. Am. Chem. Soc. 2010 Feb 17;132(6):1748-9

Olsen SK, Ota N, Kishishita S, Kukimoto-Niino M, Murayama K, Uchiyama H, Toyama M, Terada T, Shirouzu M, Kanagawa O, Yokoyama S. Crystal structure of the interleukin 15- interleukin 15 receptor alpha complex: insights into trans and cis presentation. J. Biol. Chem. 2007 Dec 21;282(51):37191-204.

Olsen SK, Bromleigh C, Ibrahimi OA, Eliseenkova AV, Zhang F, Linhardt RJ, Joyner AL, Mohammadi, M. Structural basis by which alternative splicing modulates the biological activity of FGF8 in the brain. Genes Dev. 2006 Jan 15;20(2):185-98.

top of page

 
 
 

© 2012  Medical University of South Carolina | Disclaimer