Carroll A. Campbell, Jr. Neuropathology Laboratory (Brain Bank)

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brain bank logo(December 2011) The Carroll A. Campbell, Jr. Neuropathology Laboratory continues to lead efforts to advance our understanding of neurological diseases. One of the major hurdles in battling these diseases is early detection. To address this problem, researchers have sought new ways to recognize the early stages of the brain deficits.

Recently, in collaboration with Dr. Mark Eckert in the Otolaryngology Department, the laboratory began developing new imaging techniques of postmortem brain tissue to examine whether certain brain diseases can be identified before cognitive and physical deficits are seen. An area in the brainstem called the locus coeruleus degenerates early in Parkinson’s disease (PD), and this degeneration may be involved in cognitive deficits that occur in patients with PD early in the disease progress, perhaps even before motor function deteriorates. This project aims at eventually developing in vivo imaging techniques to detect degeneration in this brain stem region, to be used as a potential "Mammogram" for the brain in the future.

This project is part of the Udall grant application from the Movement Disorders group at MUSC, led by Drs. Gary Aston-Jones and Vanessa Hinson. Udall grants are large programmatic NIH funded research facilities focusing on PD and related disorders from a translational perspective.

Dr. Granholm to study with the Karolinska Institutet to continue to develop strategies for growing the Campbell Lab (July 2011)

For several months throughout the next year, Dr. Granholm will be working side by side with researchers in the BB at KI to learn from their program and form beneficial collaborations. Dr. Granholm also plans to perform comparative studies of the incidence and causes of dementia and other age-related conditions in Swedish versus South Carolinians.

The Brain Bank at Karolinska Institutet (The BB at KI) is the central bio-repository for brain and tissue-related collection, storage, preservation, and scientific investigations on human brains at Karolinska InstitutetThe BB at KI roots its origin in the pioneristic work of Prof. Bengt Winblad, that started to collect human brains at University Hospital of Umeå in 1972.  In 1986, as Prof.Winblad moved to Stockholm as chief of the Geriatric Section of the Karolinska Institutet, the Umeå brain collection moved to Stockholm.  In 2010, the Huddinge brain bank, became The Brain Bank at Karolinska Institutet. The new name was created as sign of the increased scientific relevance and necessity of the human brain banking. The BB at KI serves and collaborates with the entire scientific community at KI, such as other national and international Institutions.

(March 31, 2011) U.S. Senator Debbie Stabenow (D-MI) introduced a resolution in the Senate that designates April as the national Parkinson’s Awareness Month.  This action signifies the importance of Parkinson’s disease, and recognizes Congress’ commitment to finding better treatments and a cure for Parkinson’s disease.  The Parkinson’s Action Network (PAN) expects that the resolution will be passed soon by the full Senate.

Sally SmithThe Circle: A Walk With Dementia author, Sally Hughes Smith, toured the neuropathology laboratory in March 2011.  The Charleston resident published The Circle with a vision of helping families and caregivers of aging, mentally frail loved ones cope with the ongoing realizations of dementia.  She will be helping promote MUSC's brain bank amongst her readers. 100% of the net proceeds will benefit research into Alzheimer's disease, Parkinson's disease, dementia, vision and hearing loss and other age-related problems.
New Hope for Solving Parkinson's Disease Puzzle ScienceDaily
(Mar. 1, 2011) — A protein pathway that may hold the secret to understanding Parkinson's disease has been discovered and explained by Iowa State University researchers.

Associated Content 
from Yahoo!

Why Brain Tissue Donation is so Important and How You Can Be a Vital Part in Research: Examination of Brain Tissue is the Only Hope for Finding Better Treatments and a Cure for Neurological Diseases
Freida Thomas, Yahoo! Contributor Network
(Feb 10, 2011)

Dr. Granholm spoke about "Connections Between Movement Disorders & Cognitive Impairment" at Aging Research Day 2011 (February 4, 2011) The annual Aging Research Day is a research conference focusing on aging and age-related diseases. This conference can play a major role in raising awareness, enhancing distributive knowledge and disseminating research regarding age-related health issues, not only in South Carolina but throughout the Southeast region of the US to health care providers, students in health-related fields and older citizens.  This year's topic was Aging and Mobility and was held at the Columbia Conference Center. 

Mother's Alzheimer's Disease May Boost Your Risk - (Feb. 2011) click title to read article about how individuals with maternal history of neurological disorders are affected.

Mayor Harry M. Hallman, Jr. aimed to help researchers (January 13, 2011)Donated his brain to the Carroll A. Campbell Jr. Neuropathology Laboratory at the Medical University of South Carolina.

Brisk Walks May Boost Memory in Older Adults - (Jan. 2011) click title to read article: After one year of exercise, hippocampus region was bigger, study finds

Nicholas Gregory & Rebekah Hardin visited the Rush Alzheimer's Disease Center Laboratory in Chicago, IL. (November 10, 2010)  The laboratory has two major activities: to provide a state of the art neuropathological diagnosis of Alzheimer’s disease by post-mortem evaluation and to facilitate research into the neurobiologic causes of Alzheimer’s disease.  More than 1,400 brain autopsies have been conducted by the Rush Alzheimer's Disease Center Laboratory since its inception in 1987.  Through their meetings, they learned many valuable things that they have been able to bring back to MUSC's Carroll A. Campbell Jr., Nuropathology Lab.

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