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Training to Improve Cardiovascular Therapies

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 Cardio Training Grant | Postdoctoral Fellowships | Fellow Publications

Recent Publications

Publications during Postdoctoral Fellowships from the last 10 years:

Harston RK, Moschella PC, McKillop JC, Baicu CF, Balasubramanian S, Zile MR, Kuppuswamy D. Acute rapamycin treatment augments both protein ubiquitination and Akt activation in pressure overloaded rat myocardium. Am J Physiol Heart Circ Physiol. 2011; 300(5): H1696-706. PMCID: PMC3094075.

Jones JA, Ruddy JM, Bouges S, Zavadzkas JA, Brinsa TA, Stroud RE, Mukherjee R, Spinale FG, Ikonomidis JS. Alterations in membrane type-1 matrix metalloproteinase abundance after the induction of thoracic aortic aneurysm in a murine model. Am J Physiol Heart Circ Physiol. 2010; 299(1):H114-24. PMCID: PMC2904124.

Ruddy JM, Jones JA, Stroud RE, Mukherjee R, Spinale FG, Ikonomidis JS. Differential effect of wall tension on matrix metalloproteinase promoter activation in the thoracic aorta. J Surg Res. 2010; 160(2):333-9. PMCID: PMC2859117.

Ruddy JM, Ikonomidis JS. Trauma to the great vessels. In LH Cohn (Ed.), Cardiac Surgery in the Adult, 4th edition, McGraw-Hill, NY 2010.

Yarbrough WM, Mukherjee R, Stroud RE, Meyer EC, Escobar GP, Sample JA, Hendrick JW, Mingoia JT, Spinale FG. Caspase inhibition modulates left ventricular remodeling following myocardial infarction through cellular and extracellular mechanisms. J Cardiovasc Pharmacol. 2010; 55(4):408-16. PMCID: PMC2880531.

Swain M, Thirupathi R, Krishnarjuna B, Eaton EM, Kibbey MM, Rosenzweig SA, Atreya HS. Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures. Chem Commun (Camb). 2010; 46(2):216-8.

Cheng G, Takahashi M, Shunmugavel A, Wallenborn JG, Depaoli-Roach AA, Gergs U, Neumann J, Kuppuswamy D, Menick DR, Cooper G 4th. Basis for MAP4 Dephosphorylation-related Microtubule Network Densification in Pressure Overload Cardiac Hypertrophy. J Biol Chem 2010; 285 (49): 38125-40.

Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches. Int J Hematol. 2010; 91(3):353-9.

Ogawa M, Larue AC, Watson PM, Watson DK. Hematopoietic stem cell origin of connective tissues. Exp Hematol. 2010; 38(7):540-7. PMCID: In Process.

Schnellmann RG, Covington MD. Calcium and proteases. Comprehensive Toxicology, 2nd Edition, 2010.

Mehrotra M, Rosol M, Ogawa M, Larue AC. Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies. Exp Hematol. 2010; 38(7):593-602. PMCID: PMC2896305.

Moussa O, LaRue AC, Abangan RS Jr, Williams CR, Zhang XK, Masuya M, Gong YZ, Spyropoulos DD, Ogawa M, Gilkeson G, Watson DK. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol. 2010; 30(21):5194-206. PMCID: PMC295306.

Covington MD, Arrington DD, Schnellmann RG. Calpain 10 is required for cell viability and is decreased in the aging kidney. Am J Physiol Renal Physiol. 2009; 296(3):F478-86. PMCID: PMC2660187.

Chandrasekaran S, Peterson RE, Mani SK, Addy B, Buchholz AL, Xu L, Thiyagarajan T, Kasiganesan H, Kern CB, Menick DR. Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. FASEB J. 2009; 23(11):3851-64. PMCID: PMC2775004.

Damon BJ, Rémond MC, Bigelow MR, Trusk TC, Xie W, Perucchio R, Sedmera D, Denslow S, Thompson RP. Patterns of muscular strain in the embryonic heart wall. Dev Dyn. 2009; 238(6):1535-46. PMCID: PMC2757264.

Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR. Organ printing: tissue spheroids as building blocks. Biomaterials. 2009; 30(12):2164-74.

Klein AL, Berkaw MN, Buse MG, Ball LE. O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs. Mol Cell Proteomics. 2009; 8(12):2733-45. PMCID: PMC2816021.

Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E, Schulte BA, Watson PM, Watson DK, Ogawa M. Hematopoietic stem cell origin of adipocytes. Exp Hematol. 2009; 37(9):1108-20, 1120.e1-4. PMCID: PMC2740899.

Shirai K, Sera Y, Bulkeley W, Mehrotra M, Moussa O, LaRue AC, Watson DK, Stuart RK, Lazarchick J, Ogawa M. Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia. Exp Hematol. 2009; 37(12):1464-71. PMCID: PMC2802494.

Morinelli TA, Kendall RT, Luttrell LM, Walker LP, Ullian ME. Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation. J Pharmacol Exp Ther. 2009; 330(1):118-24.

Ruddy JM, Jones JA, Stroud RE, Mukherjee R, Spinale FG, Ikonomidis JS. Differential effects of mechanical and biological stimuli on matrix metalloproteinase promoter activation in the thoracic aorta. Circulation. 2009; 120(11 Suppl):S262-8. PMCID: PMC2774261.

Kendall RT, Luttrell LM. Diversity in arrestin function. Cell Mol Life Sci. 2009; 66(18):2953-73.

Ruddy JM, Jones JA, Spinale FG, Ikonomidis JS. Regional heterogeneity within the aorta: relevance to aneurysm disease. J Thorac Cardiovasc Surg. 2008; 136(5):1123-30. PMCID: PMC2679174.

Hunter AW, Gourdie RG. The second PDZ domain of zonula occludens-1 is dispensable for targeting to connexin 43 gap junctions. Cell Commun Adhes. 2008; 15(1):55-63.

Shores KS, Udugamasooriya DG, Kodadek T, Knapp DR. Use of peptide analogue diversity library beads for increased depth of proteomic analysis: application to cerebrospinal fluid. J Proteome Res. 2008; 7(5):1922-31.

Waller LN, Shores K, Knapp DR. Shotgun proteomic analysis of cerebrospinal fluid using off-gel electrophoresis as the first-dimension separation. J Proteome Res. 2008; 7(10):4577-84.

Giguere CJ, Covington MD, Schnellmann RG. Mitochondrial calpain 10 activity and expression in the kidney of multiple species. Biochem Biophys Res Commun. 2008; 366(1):258-62. PMCID: PMC2215326.

Kinsey GR, Blum JL, Covington MD, Cummings BS, McHowat J, Schnellmann RG. Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis. J Lipid Res. 2008; 49(7):1477-87.

Covington MD, Schnellmann RG. Pharmacological aspects of nephrotoxicity. Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals, 3rd Edition, 2008.

Waller LN, Shores K, Knapp DR. Shotgun proteomic analysis of cerebrospinal fluid using off-gel electrophoresis as the first-dimension separation. J Proteome Res. 2008; 7(10):4577-84.

Kilpatrick EL, Hildebrandt JD. Sequence dependence and differential expression of Ggamma5 subunit isoforms of the heterotrimeric G proteins variably processed after prenylation in mammalian cells. J Biol Chem. 2007; 282(19):14038-47.

Robinson KA, Ball LE, Buse MG. Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2007; 292(3):E884-90.

LaRue AC, Ogawa M. Hematopoietic Origin of Fibrocytes. In Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses. Editor, Richard Bucala. Yale University, USA, 2007.

Ogawa M, LaRue AC. Origin of fibroblast colony-forming units. Exp Hematol. 2007; 35(9):1319-20.

Shores KS, Knapp DR. Assessment approach for evaluating high abundance protein depletion methods for cerebrospinal fluid (CSF) proteomic analysis. J Proteome Res. 2007; 6(9):3739-51.

Visconti RP, Ebihara Y, LaRue AC, Fleming PA, McQuinn TC, Masuya M, Minamiguchi H, Markwald RR, Ogawa M, Drake CJ. An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells. Circ Res. 2006; 98(5):690-6.

Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood. 2006; 107(1):358-66.

Visconti RP, Ebihara Y, LaRue AC, Fleming PA, McQuinn TC, Masuya M, Minamiguchi H, Markwald RR, Ogawa M, Drake CJ. An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells. Circ Res. 2006; 98(5):690-6.

LaRue AC, Masuya M, Ebihara Y, Fleming PA, Visconti RP, Minamiguchi H, Ogawa M, Drake CJ. Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors. Exp Hematol. 2006; 34(2):208-18.

Ebihara Y, Masuya M, Larue AC, Fleming PA, Visconti RP, Minamiguchi H, Drake CJ, Ogawa M. Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol. 2006; 34(2):219-29.

Ogawa M, LaRue AC, Drake CJ. Hematopoietic origin of fibroblasts/myofibroblasts: Its pathophysiologic implications. Blood. 2006; 108(9):2893-6.

Kibbey MM, Jameson MJ, Eaton EM, Rosenzweig SA. Insulin-like growth factor binding protein-2: contributions of the C-terminal domain to insulin-like growth factor-1 binding. Mol Pharmacol. 2006; 69(3):833-45.

LaRue AC, Masuya M, Ebihara Y, Fleming PA, Visconti RP, Minamiguchi H, Ogawa M, Drake CJ. Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors. Exp Hematol. 2006; 34(2):208-18.

Ebihara Y, Masuya M, Larue AC, Fleming PA, Visconti RP, Minamiguchi H, Drake CJ, Ogawa M. Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes. Exp Hematol. 2006; 34(2):219-29.

Kawamori T, Osta W, Johnson KR, Pettus BJ, Bielawski J, Tanaka T, Wargovich MJ, Reddy BS, Hannun YA, Obeid LM, Zhou D. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006; 20(2):386-8.

Hammad SM, Taha TA, Nareika A, Johnson KR, Lopes-Virella MF, Obeid LM. Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells. Prostaglandins Other Lipid Mediat. 2006; 79(1-2):126-40.

El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM. Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. J Biol Chem. 2006; 281(42):31399-407.

Apple KA, Yarbrough WM, Mukherjee R, Deschamps AM, Escobar PG, Mingoia JT, Sample JA, Hendrick JW, Dowdy KB, McLean JE, Stroud RE, O'Neill TP, Spinale FG. Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling. J Cardiovasc Pharmacol. 2006; 47(2):228-35.

Flack EC, Lindsey ML, Squires CE, Kaplan BS, Stroud RE, Clark LL, Escobar PG, Yarbrough WM, Spinale FG. Alterations in cultured myocardial fibroblast function following the development of left ventricular failure. J Mol Cell Cardiol. 2006; 40(4):474-83.

Miettinen TA, Klett EL, Gylling H, Isoniemi H, Patel SB. Liver transplantation in a patient with sitosterolemia and cirrhosis. Gastroenterology. 2006; 130(2):542-7.

Gourdie RG, Ghatnekar GS, O'Quinn M, Rhett JM, Barker RJ, Zhu C, Jourdan J, Hunter AW. The unstoppable connexin43 carboxyl-terminus: new roles in gap junction organization and wound healing. Ann N Y Acad Sci. 2006; 1080:49-62.

Smith BT, Mussell JC, Fleming PA, Barth JL, Spyropoulos DD, Cooley MA, Drake CJ, Argraves WS. Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006 6:30.

Balasubramanian S, Shiraishi H, Yamane K, Mani S, Wiley CD, Tuxworth WJ Jr, Copper G IV, and Kuppuswamy D. Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. J Mol Cell Cardiol. 2006; 41(4):669-79.

Johnson KR, Johnson KY, Crellin HG, Ogretmen B, Boylan AM, Harley RA, Obeid LM. Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. J Histochem Cytochem. 2005; 53(9):1159-66.

Stahelin RV, Hwang JH, Kim JH, Park ZY, Johnson KR, Obeid LM, Cho W. The mechanism of membrane targeting of human sphingosine kinase 1. J Biol Chem. 2005; 280(52):43030-8.

Deschamps AM, Yarbrough WM, Squires CE, Allen RA, McClister DM, Dowdy KB, McLean JE, Mingoia JT, Sample JA, Mukherjee R, Spinale FG. Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity. Circulation. 2005; 111(9):1166-74.

Deschamps AM, Apple KA, Leonardi AH, McLean JE, Yarbrough WM, Stroud RE, Clark LL, Sample JA, Spinale FG. Myocardial interstitial matrix metalloproteinase activity is altered by mechanical changes in LV load: interaction with the angiotensin type 1 receptor. Circ Res. 2005; 96(10):1110-8.

Blom AS, Mukherjee R, Pilla JJ, Lowry AS, Yarbrough WM, Mingoia JT, Hendrick JW, Stroud RE, McLean JE, Affuso J, Gorman RC, Gorman JH 3rd, Acker MA, Spinale FG. Cardiac support device modifies left ventricular geometry and myocardial structure after myocardial infarction. Circulation. 2005; 112(9):1274-83.

Ervin LA, Ball LE, Crouch RK and Schey KL. Phosphorylation and glycosylation of bovine lens MP20. Invest Ophthalmol Vis Sci 46(2):627-35, 2005.

Hunter AW, Barker RJ, Zhu C, Gourdie RG. Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell. 16:5686-5698, 2005.

Taha TA, Osta W, Kozhaya L, Bielawski J, Johnson KR, Gillanders WE, Dbaibo GS, Hannun YA, Obeid LM. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem. 2004; 279(19):20546-54.

Shegogue D, Trojanowska M. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem. 2004; 279(22):23166-75.

Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004; 279(52):53994-4001.

Sato M, Shegogue D, Hatamochi A, Yamazaki S, Trojanowska M. Lysophosphatidic acid inhibits TGF-beta-mediated stimulation of type I collagen mRNA stability via an ERK-dependent pathway in dermal fibroblasts. Matrix Biol. 2004; 23(6):353-61.

Klett EL, Patel SB. Biomedicine. Will the real cholesterol transporter please stand up. Science. 2004; 303(5661):1149-50.

Klett EL, Lu K, Kosters A, Vink E, Lee MH, Altenburg M, Shefer S, Batta AK, Yu H, Chen J, Klein R, Looije N, Oude-Elferink R, Groen AK, Maeda N, Salen G, Patel SB. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2004; 2:5.

Klett EL, Lee MH, Adams DB, Chavin KD, Patel SB. Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine. BMC Gastroenterol. 2004; 4:21.

Zhu C, Barker RJ, Hunter AW, Zhang Y, Jourdan J and Gourdie RG. Quantitative analysis of ZO-1 co-localization with Cx43 gap junction plaques in cultures of rat neonatal cardiomyocytes. Microsc Microanal. 11:244-248, 2004. (Nominated for Paper of the Year by Molecular Biology of the Cell.)

Drake CJ, Fleming PA, LaRue AC, Barth JL, Chintalapudi MR and Argraves WS. Differential distribution of cubilin and megalin expression in the mouse embryo. Anatomical Record Part 277A:163-170, 2004.

LaRue AC, Zile MH and Drake CJ. Normal vascular morphogenesis requires retinol-mediated regulation of endothelial cell numbers. Developmental Dynamics 230(4):666-70, 2004.

Tuxworth WJ, Saghir AN, Spruill LS, Menick DR and McDermott PJ. Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: The consequence of secondary structure in the 5´-untranslated region of mRNA. Biochemical Journal 378(Pt 1):73-82, 2004.

Walgren JL, Amani Z, McMillan JM, Locher M and Buse MG. Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes. Metabolism 53(2):165-73, 2004.

Mukherjee R, Yarbrough WM, Reese ES, Leiser JS, Sample JA, Mingoia JT, Hardin AE, Stroud RE, McLean JE, Hendrick JW and Spinale FG. Myocyte contractility with caspase inhibition and simulated hyperkalemic cardioplegic arrest. Ann Thorac Surg 77(5):1684-90, 2004.

Yarbrough WM, Mukherjee R, Squires CE, Reese ES, Leiser JS, Stroud RE, Sample JA, Hendrick JW, Mingoia JT, McLean JE, Hardin AE, Dowdy KB and Spinale FG. Caspase inhibition attenuates contractile dysfunction following cardioplegic arrest and rewarming in the setting of left ventricular failure. J Cardiovasc Pharmacol 44(6):645-50, 2004.

Yu H, Pandit B, Klett E, Lee MH, Lu K, Helou K, Ikeda I, Egashira N, Sato M, Klein R, Batta A, Salen G, Patel SB. The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats. BMC Cardiovasc Disord. 2003; 3:4.

Pettus BJ, Bielawski J, Porcelli AM, Reames DL, Johnson KR, Morrow J, Chalfant CE, Obeid LM, Hannun YA. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003; 17(11):1411-21.

Yarbrough WM, Spinale FG. Large animal models of congestive heart failure: a critical step in translating basic observations into clinical applications. J Nucl Cardiol. 2003; 10(1):77-86.

Hamilton MH, Cook LA, McRackan TR, Schey KL and Hildebrandt JD. Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate. Proc Natl Acad Sci USA 100(9):5081-6, 2003.

Hunter AW, Jourdan J and Gourdie RG. Fusion of GFP to the carboxyl terminus of connexin43 increases gap junction size in HeLa cells. Cell Commun Adhes 10(4-6):211-214, 2003.

Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C and Obeid LM. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J Biol Chem 278(36):34541-7, 2003.

Ishikawa F, Drake CJ, Yang S, Fleming P, Minamiguchi H, Visconti RP, Crosby CV, Argraves WS, Harada M, Key LL Jr, Livingston AG, Wingard JR and Ogawa M. Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann N Y Acad Sci 2003 May;996:174-85, 2003.

Walgren JL, Vincent TS, Schey KL and Buse MG. High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin. Am J Physiol Endocrinol Metab 284(2):E424-34, 2003.

Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Baskin JM, Deschamps AM, Lowry AS, Escobar GP, Lucas DG, Yarbrough WM, Zile MR and Spinale FG. Myocardial infarct expansion and matrix metalloproteinase inhibition. Circulation 107(4):618-25, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Hendrick JW, Sample JA, Dowdy KB, McLean JE, Mingoia JT, Crawford FA Jr and Spinale FG. Modulation of calcium transport improves myocardial contractility and enzyme profiles after prolonged ischemia-reperfusion. Ann Thorac Surg 76(6):2054-61, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Mingoia JT, Sample JA, Hendrick JW, Dowdy KB, McLean JE, Lowry AS, O'Neill TP and Spinale FG. Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling. Circulation 108(14):1753-9, 2003.

Yarbrough WM, Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Escobar GP, Joffs C, Lucas DG, Crawford FA Jr and Spinale FG. Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs. J Thorac Cardiovasc Surg 125(3):602-10, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Mingoia JT, Sample JA, Hendrick JW, Dowdy KB, McLean JE, Stroud RE and Spinale FG. Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability. J Thorac Cardiovasc Surg 126(5):1489-97, 2003.

Yarbrough WM and Spinale FG. Large animal models of congestive heart failure: a critical step in translating basic observations into clinical applications. J Nucl Cardiol 10(1):77-86, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Sample JA, McLean JE, Dowdy KB, Hendrick JW, Gibson WC, Hardin AE, Mingoia JT, White PC, Stiko A, Armstrong RC, Crawford FA and Spinale FG. Pharmacologic inhibition of intracellular caspases after myocardial infarction attenuates left ventricular remodeling: a potentially novel pathway. J Thorac Cardiovasc Surg 126(6):1892-9, 2003.

Klett EL, Patel S. Genetic defenses against noncholesterol sterols. Curr Opin Lipidol. 2003; 14(4):341-5.

Sato M, Shegogue D, Gore EA, Smith EA, McDermott PJ, Trojanowska M. Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J Invest Dermatol. 2002; 118(4):704-11.

Gore-Hyer E, Shegogue D, Markiewicz M, Lo S, Hazen-Martin D, Greene EL, Grotendorst G, Trojanowska M. TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am J Physiol Renal Physiol. 2002; 283(4):F707-16.

Argraves KM, Obeid LM and Hannun YA. Sphingohpids in vascular biology. Proceedings for: eicosanoids and other bioactive lipids in cancer, inflammation and related diseases. Adv Exp Med Biol 507:439-44, 2002.

Cook LA, Wilcox MD, Dingus J, Schey KL and Hildebrandt JD. Separation and analysis of G protein gamma subunits. Methods Enzymol 344:209-33, 2002.

Schey KL, Busman M, Cook LA, Hamm H and Hildebrandt JD. Structural characterization of intact G protein gamma subunits by mass spectrometry. Methods Enzymol 344:586-97, 2002.

Johnson KR and Fan W. Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. Anticancer Res 22(6A):3197-204, 2002.

Johnson KR, Becker KP, Facchinetti MM, Hannun YA and Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem 277(38):35257-62, 2002.

Hannun YA, Luberto C and Argraves KM. Enzymes of sphingohpid metabolism: from modular to integrative signaling. Biochemistry 40(16):4893-903, 2001.

Christopher J, Velarde V, Zhang D, Mayfield D, Mayfield R, and Jaffa AA. Regulation of B2-kinin receptors by high glucose in vascular smooth muscle cells. Am. J. Physiol. 280:Hl537-Hl 546, 2001.

Christopher JT, Mayfield RM and Jaffa AA. Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. Hypertension 38(3 Pt 2):602-5, 2001.

Velarde V, Jenkins A, Christopher J, Joyce KC, Mayfield D, Lyons T, Mayfield R and Jaffa AA. Activation of MAPK activation by modified low-density lipoproteins in vascular smooth muscle cells. Journal of Applied Biology 91(3):1412-20, 2001.

Cook LA, Schey KL, Cleator JH, Wilcox MD, Dingus J and Hildebrandt JD. Identification of a region in G protein gamma subunits conserved among species variants but hypervariable among subunit isoforms. Protein Sci 10(12):2548-55, 2001.

Gunasinghe SK, Ikonomidis J and Spinale FG. Contributory role of matrix metalloproteinases in cardiovascular remodeling. Current Drug Targets-Cardiovascular and Haematological Disorders 1(2):75-91, 2001.

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