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Training to Improve Cardiovascular Therapies

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 Cardio Training Grant | Research Areas | Mechanisms of Cardiovascular Development

Mechanisms of Cardiovascular Development

The area offers training and research in genetics and developmental biology, with investigators utilizing a variety of animal models to assess gene functions in embryonic development. Modern developmental genetics has become a central organizing field in all traditional disciples of biology, including cell biology, molecular biology, anatomy, evolution, and ecology. It has also contributed greatly to more practical fields such as medicine, environmental science and agriculture. The model systems studied by faculty members include Drosophila (fruit fly) for vascular system development, zebrafish for cardiac function and environmental impact on embryogenesis, chick for the formation of the cardiovascular system, mice for a variety of organogenesis studies, hematopoiesis, heart morphogenesis and human familial diseases for genetic linkage studies. In addition to transgenic and knockout technology, a variety of cell culture systems, including those for human stem cells, are utilized in the research.


Christopher Drake, Ph.D.Vasculogenesis
Brett Harris, Ph.D.The Development of the Atrio-ventricular Conduction System
Amanda LaRue, Ph.D.Hematopoietic Stem Cells in the Development and Progression of Solid Tumors
Kyo Ho Lee, M.D., Ph.D.Transcriptional Regulation in Cardiac Development
Edward L. Krug, Ph.D.Assessing the Anatomical Proteome of Heart Morphogenesis
Steven W. Kubalak, Ph.D.Signaling Mechanisms Regulating Cardiac Remodeling
Roger R. Markwald, Ph.D.Developmental Basis of Cardiovascular Disease
Terrence O'Brien, M.D.Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System
Arno Wessels, Ph.D.Mechanisms of Cardiac Morphogenesis