| Cell regulation encompasses all the functions cells carry out to maintain homeostasis, in particular their responses to extracellular signals (hormones, neurotransmitters, etc.) and how cells transduce intracellular responses prompted by such signals. In addition to endogenous agents, many drugs and environmental agents use these same mechanisms to produce their most important effects. Understanding of cell signaling processes is fundamental to all areas of cardiovascular research. Numerous research opportunities exist within this program ranging from studies exploring new cell signaling mechanisms, to those examining aberrant signaling mechanisms associated with cardiovascular disease. Significantly, many of the recent breakthroughs in cardiovascular therapeutics result from basic studies on signaling molecules. |  |
| Kelley Argraves, Ph.D. | Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis |
| Scott W. Argraves, Ph.D. | Extracellular Matrix Biology |
| John Baatz, Ph.D. | Characterization of Hemoglobin and Surfactant Protein in Distal Airway Cells |
| Craig Beeson, Ph.D. | Regulation of Cardiac Bioenergetics during Stress Responses |
| Maria Buse, M.D., Ph.D. | Diabetes: Mechanisms of Insulin Resistance |
| |
| James A. Cook, Ph.D. | Signal Transduction Pathways in Shock |
| Samar Hammad, Ph.D. | Sphingolipid Signaling Response to Modified Low-density Lipoprotein-Immune Complexes in Human Macrophages |
| Brett Harris, Ph.D. | The Development of the Atrio-ventricular Conduction System |
| Steven W. Kubalak, Ph.D. | Signaling Mechanisms Regulating Cardiac Remodeling |
| Dhandapani Kuppuswamy, Ph.D. | Growth and Protection of Hypertrophing Myocardium |
| Kyo Ho Lee, M.D., Ph.D. | Transcriptional Regulation in Cardiac Development |
| Louis Luttrell, M.D., Ph.D. | G Protein-coupled Receptor Signaling in the Cardiovascular System |
| Paul J. McDermott, Ph.D. | Translational Regulation of Cardiac Protein Synthesis |
| Donald R. Menick, Ph.D. | Regulation of Gene Expression in Cardiac Myocytes |
| Suniti Misra, Ph.D. | Role of Hyaluronan in Intimal Thickening in Congenital Birth Defect and Atherosclerosis |
| Terrence X. O'Brien, M.D. | Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System |
| Rick Schnellmann, Ph.D. | Elucidation of Signaling Pathways of Cell Injury, Death and Regeneration |
| Steve Tomlinson, Ph.D. | The Complement System and Vascular Inflammation |
| Bryan Toole, Ph.D. | Functions of Hyaluronan and Emmprin in Oncogenic, Inflammatory and Atherosclerotic Signaling Pathways |
