Proteomics

The Cardiovascular Proteomics group provides trainees exposure to new technologies for proteomic analysis and helps our fellows apply such approaches to generate discoveries in specific areas of cardiovascular research. Our faculty are using proteomic analysis to study the basic underlying mechanisms of congestive heart failure, extracellular matrix remodeling events in heart development and disease, proteomic analysis of cardiovascular disease risk and several new technologies for proteomic assessment of heart disease. One of our current trainees is developing proteomic methods to study diastolic dysfunction. Work on his and other projects is being initiated using a synergistic combination of contemporary two-dimensional gel electrophoresis in a new high throughput facility, a well-established mass spectrometry facility, and state-of-the-art methods of biological systems analysis.