The overarching research goal of Dr. Sameer Tipnis is to ensure that imaging provides physicians with high-quality, clinically relevant information while keeping radiation doses to patients as low as possible. Technological advancement in an imaging technology does not always translate to clinical usefulness. To assess clinical relevance, Dr. Tipnis uses a program based on alternative forced choice methodology that allows the diagnostic sensitivity of a new technology to be compared with that of an existing one. In one study, for example, physician volunteers were asked to attempt to detect lesions on images generated using a new iterative construction technique (Iterative Reconstruction in Image Space [IRIS]) and on images generated without the benefit of this technique. Such testing allows a minimum diagnostic threshold to be established for each test and for the comparison of those values. In this example, Tipnis found that IRIS allowed for noise reduction, meaning that the dose of radiation could be reduced without affecting image quality or that an improved image could be generated at current radiation doses. The other clinical role for Dr. Tipnis is to provide physicians with information on the radiation dose from common imaging techniques to radiosensitive organs. Patients have become much more aware of radiation exposure from imaging technologies and more likely to question their physicians about radiation risks. Dr. Tipnis’s research provides clinicians with the information they need to field such questions and to determine the benefit-to-risk ratio and thus the appropriateness of a given imaging technology for a particular patient.