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Truman R. Brown, Ph.D., Scientific Director

Truman R. Brown, PhD, Scientific Director of the Center for Biomedical Imaging, was a founding editor of NMR in Biomedicine and served as its North American Editor for eight years. Brown holds more than 10 patents and patent applications, most notably for chemical shift imaging, a technique for measuring metabolites that has helped advance our understanding of schizophrenia and the ways some tumors respond to treatment. He is currently interested in using simultaneous electroencephalography (EEG) and functional magnetic resonance (fMRI) imaging to study Alzheimer’s and other neurological disease as well as aging-related changes to the brain.  The EEG is much faster than the fMRI, but the fMRI provides better imaging of the deep structures of the brain. Brown thinks that harnessing the power of both to study brain activity in the same subject performing a given task and noting correlations between their findings could help us better pinpoint early changes in the brains of those with Alzheimer’s, dementia, or other degenerative neurologic disease, potentially allowing for preventive measures to be taken before the worst of the damage is done. He is also interested in using advanced imaging to aid in stroke rehabilitation. In addition, Brown has developed and continues to refine a method for removing motion artifact from MRI, which can be a serious barrier to optimal imaging in patients with Parkinson’s or in children. As Scientific Director of the CBI, Brown hopes to make the 3-Tesla Siemens scanner housed in the center a robust and reliable resource for MUSC colleagues who want to incorporate a new imaging methodology into their research.

 

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