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Jens Jensen, Ph.D.

The research of Jens Jensen, PhD, focuses on the development and application of new magnetic resonance imaging (MRI) techniques for the quantitative assessment of biological tissues in vivo. A major interest is the use of diffusion MRI (dMRI) to investigate diffusional non-Gaussianity, which is a sensitive indicator of a tissue’s microenvironment. Diffusional kurtosis imaging (DKI) is a specific dMRI method, which Jens first proposed together with Dr. Joseph Helpern, that quantifies non-Gaussianity by estimating the kurtosis of the water diffusion displacement probability distribution function. With his collaborators, Jens is investigating the application of DKI to stroke, Alzheimer’s disease and other neuropathologies.  Another research area is the characterization of endogenous, non-heme tissue iron by means of MRI. In the brain, disruption of iron homeostasis has been implicated in a variety of neuropathologies, including Alzheimer’s. Jens has helped to develop a technique known as magnetic field correlation (MFC) imaging, which is currently being applied to quantify brain iron for several diseases. He also works on the quantification of iron in the liver and heart for iron overload disorders, using a customized multiple spin echo technique that allows for the separate estimation of ferritin and hemosiderin iron concentrations.

 

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