The research agenda of Maria V. Spampinato, M.D., Associate Professor of Radiology, is to apply advanced imaging methodologies to assess the rate of change in cognition and brain structure in patients with mild cognitive impairment and early Alzheimer’s disease. In collaboration with Jacobo E. Mintzer, M.D., she has conducted volumetric assessment of the brains of patients with mild cognitive impairment and Alzheimer’s disease using magnetic resonance imaging in an effort to determine the role of apolipoprotein E in the progression of cognitive decline and atrophy rates. She is an investigator of the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a 5-year multi-institutional study collecting clinical and imaging data on patients with normal cognitive impairment, mild cognitive impairment and Alzheimer’s disease. She is also interested in the use of advanced imaging techniques to characterize brain tumors and to predict treatment response and outcome. In collaboration with Zoran Rumboldt, M.D., and Pierre Giglio, M.D., she has conducted retrospective evaluations of the usefulness of perfusion-weighted magnetic resonance imaging for glioma grading and outcome prediction. She is collaborating with faculty at MUSC’s Center for Biomedical Imaging with expertise in Diffusional Kurtosis Imaging (DKI), including Joseph Helpern, Ph.D, Fatima de Falangola, M.D., Ph.D., and Ali Tabesh, Ph.D., to further both her brain tumor and Alzheimer’s disease work.