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Saeid Taheri, Ph.D.

The research of Saeid Taheri, PhD, focuses on the study and modeling of neurovascular, neuroinflammatory diseases. In Taheri’s opinion, many cerebrovascular diseases, including stroke, multiple sclerosis, and Alzheimer’s disease, have a vascular component, and research related to these diseases would benefit from consideration of the “neurovascular unit” (ie, neurons, capillaries, and glia). Taheri uses animal models of cerebrovascular diseases with advanced imaging techniques and mathematical modeling to understand the mechanism of progression of neurovascular disease.

In his current studies on stroke, Taheri uses advanced neuroimaging techniques to understand the behavior of the “neurovascular unit” and the timing of changes, in particular changes in the permeability of the blood brain barrier in a middle cerebral artery occlusion (MCAO) model of ischemic stroke. Taheri also uses imaging techniques to study whether chronic inflammation causes neurodegenerative diseases in murine models of Alzheimer’s disease, as for example whether hypertension could predispose a person to the cognitive impairment that is a prelude to Alzheimer’s in humans.

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