Drawing on a wealth of software and algorithm development experience, including a stint at IBM, Mark Van Horn, PhD, specializes in the processing and analysis of the immense amounts of data obtained from sophisticated imaging technologies. Algorithms can be tailored to the particular research needs or goals of investigators. For example, Van Horn has developed software to measure the permeability and perfusion parameters of brain tissue from magnetic resonance images using a gadolinium contrast agent. He also worked on the development of a 3D imaging system to guide a minimally invasive liver surgery to relieve portal hypertension. In addition to working with his colleagues to optimize their research and clinical practice, he strives continually to refine existing computer programs to improve their quality, efficiency, and performance.