Dr. Xue-Zhong Yu received a Bachelor of Science degree in Medicine (an MD equivalent) and then a Master of Science in Immunology from Peking University Health Sciences Center in Beijing China. After his residency in Nanchang China, he completed a postdoctoral fellowship at the Fred Hutchinson Cancer Research Center in Seattle, Washington.
Dr. Yu's lab research focuses on the biology of graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) after allogeneic hematopoietic stem cell transplantation (HSCT). The ultimate goal of these studies is to prevent or treat GVHD while preserving GVL effect, which could greatly enhance the therapeutic potential of HSCT. Because T cells play central role to induce GVHD and mediated GVL effect, understanding T-cell response to normal tissue versus tumor cells is critical for achieving the ultimate goal. The major lines of work in Dr. Yu’s Lab include: 1) T-cell differentiation and GVHD development; 2) Control of GVHD development by targeting protein kinases essential for T-cell survival and function; 3) Biology of regulation T cells (Tregs) and their potential application in the control of GVHD; 4) Regulation of T-cell mediated GVHD and GVL through costimulation and adhesion.