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Center for Cell Death, Injury and Regeneration

CorePublications

Recent Publications using the core for imaging data:

Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int. J. Cancer 131(9):2034-43, 2012.

Rahn JJ, Stackley KD, Chan SS. Opa1 is required for proper mitochondrial metabolism in early development. PLoS ONE 8(3):e59218, 2013

Josey BJ, Inks ES, Wen X, Chou CJ. Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. J. Med. Chem. 56(3):1007-22, 2013

Hance MW, Dole K, Gopal U, Bohonowych JE, Jezierska-Drutel A, Neumann CA, Liu H, Garraway IP, Isaacs JS. Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. J. Biol. Chem. 287(45)

Mehrotra M, Williams CR, Ogawa M, LaRue AC. Hematopoietic stem cells give rise to osteo-chondrogenic cells. Blood Cells Mol. Dis. 50(1):41-9, 2013.

Wu S, Dole K, Hong F, Noman AS, Issacs J, Liu B, Li Z. Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors. J. Biol. Chem. 287(24):19896-903, 2012

Jiang Y, He X, Howe PH. Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin. EMBO J. 31(10):2336-49, 2012.

Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med 4(8):761-75, 2012.

Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int. J. Cancer 131(9):2034-43, 2012.

Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int. J. Cancer 131(9):2034-43, 2012.

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. Mullen TD, Jenkins RW, Clarke CJ, Bielawski J, Hannun YA, Obeid LM. J Biol Chem. 2011 May 6;286(18):15929-42.

LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria.Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X.  J Pharmacol. Exp Ther. 2013 Jan;344(1):167-78. Epub 2012 Oct 18.

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B.  Nat Chem Biol. 2012 Oct;8(10):831-8.

Sphingomyelin synthases regulate protein trafficking and secretion.Subathra M, Qureshi A, Luberto C. PLoS One. 2011; 6(9):e23644. Epub 2011 Sep 27.

Phospholipase C and protein kinase C-beta 2 mediate insulin-like growth factor type 2-dependent sphingosine kinase 1 activation. El-Shewy HM, Abdel-Samie S.A., Al Qalam A.M., Lee M H,  Kitatani K., Anielli V., Jaffa AA, Obeid LM, Luttrell L.M. (2011): Mol Endocrinol 25(12):2144-56.

The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1-Ile4, Ile8] angiotensin II regulates a robust G protein-independent signaling network. Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy, HM., Luttrell DK, Janech MG, Luttrell LM. Wang, B., Gooz, M., Luttrell, D.K., Luttrell, L.M., and Jaffa, A.A.  (2011)J. Biol. Chem. 286(22):19880-91.

Plasma kallikrein promotes bradykinin-independent signaling in aortic vascular smooth muscle through direct activation of protease-activated receptors. Abdallah, R., Keum, J-S., El-Shewy, HM., Lee, M-H., Wang, B., Gooz, M., Luttrell, D.K., Luttrell, L.M., and Jaffa, A.A.  (2011).  J. Biol. Chem. 285: 35206-35215.

Autophagy is increased in prostate cancer cells over-  expressing acid ceramidase and enhances resistance to C6-ceramide. Turner LS, Cheng JC, Beckham TH, Norris JS, Liu X. Prostate Cancer and Prostatic Diseases. 14(1):30-7, 2011. PMID: 21116286

A cell autonomous role for sphingomyelin phosphodiesterase 3 in bone mineralization. Z. Khavandgar, C. Poirier*, C.J. Clarke, Li, J. J., Wang, N., McKee, M.D., Y.A. Hannun and M. Murshed. “A cell autonomous role for sphingomyelin phosphodiesterase 3 in bone mineralization” (2011) J. Cell Biol. 194(2).

Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through up-regulation of cathepsin B. Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang XY, Armeson  KE, Liu A, Marrison T,  Hannun YA, Liu X. International journal of cancer, Revised. 2011

Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae. Cowart LA, Gandy JL, Tholanikunnel B, Hannun YA. Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae. Biochem. J. 431(1):31-8, 2010.

Differential Trafficking of Oxidized LDL and Oxidized LDL Immune Complexes in Macrophages: Impact on Oxidative Stress. Al Gadban MM, Smith KJ, Soodavar F, Piansay C, Chassereau C, Samar M. Hammad et al. (2010)  PLoS ONE 5(9): e12534.

Heat Shock Protein 70B” (HSP70B”) Expression and Release in Response to Human Oxidized Low Density Lipoprotein Immune Complexes in Macrophages. Kent J. Smith, Waleed O. Twal, Farzan Soodavar, Gabriel Virella, Maria F. Lopes-Virella and Samar M. Hammad. (2010) JBC Vol.285, No.21, pp.15985-15993.

A requirement for bid for induction of apoptosis by photodynamic therapy with a lysosome- but not a mitochondrion-targeted photosensitizer.Chiu SM, Xue LY, Lam M, Rodriguez ME, Zhang P, Kenney ME, Nieminen AL, Oleinick NL. A requirement for bid for induction of apoptosis by photodynamic therapy with a lysosome- but not a mitochondrion-targeted photosensitizer. Photochem. Photobiol. 86(5):1161-73, 2010. PMCID: PMC2974808

Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. Wu BX, Rajagopalan V, Roddy PL, Clarke CJ, Hannun YA. J Biol Chem. 2010 Jun 4;285(23):17993-8002. Epub 2010

Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV. Qin Z, DeFee M, Isaacs JS, Parsons C. Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV. Virology 403(1):92-102, 2010.  

ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. J. Biol. Chem. 285(30):23056-63, 2010. PMCID: PMC2906299

ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. NV Oleinik, NI Krupenko and SA Krupenko. Oncogene (2010), 1-12, advance online publication

Response to Månsson et al.: Minocycline protects against the mitochondrial permeability transition after both warm and cold ischemia-reperfusion. Zhang X, Schwartz J,Zhong Z, Pediaditakis P, Ramshesh VK, Currin RT, Tikunov A, Holmuhamedov E, Theruvath TP, Lemasters JJ. Hepatology, 51, 2010

Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stress.Qin Z, Freitas E, Sullivan R, Mohan S, Bacelieri R, Branch D, Romano M, Kearney P, Oates J, Plaisance K, Renne R, Kaleeba J, Parsons C. PLoS Pathog. 6(1):e1000742, 2010. PMCID: PMC2813276   

Pivotal advance: Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes. Qin Z, Kearney P, Plaisance K, Parsons CH.  J. Leukoc. Biol. 87(1):25-34, 2010. PMCID: PMC2801620   

Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent. Lucas JT, Salimath BP, Slomiany MG, Rosenzweig SAOncogene 29(31):4449-59, 2010. PMCID: PMC2921319

Visualization and quantification of endoplasmic reticulum Ca(2+) in renal cells using confocal microscopy and Fluo5F. Eaddy AC, Schnellmann RG. Biochemical and biophysical research communications , 2010.

5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis. Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG. 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis. J. Pharmacol. Exp. Ther. 332(2):632-9, 2010. PMCID: PMC2812119

Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Rodriguez-Enriquez S, Kai Y, Maldonado E, Currin RT, Lemasters JJ. Autophagy. 2009 Nov; 5(8):1099-106.

Mitochondrial calcium and the permeability transition in cell death. Lemasters JJ, Theruvath TP, Zhong Z, Nieminen AL. Biochim Biophys Acta. 2009 Nov; 1787(11):1395-401.

Angiotensin II-induced Cyclooxygenase 2 Expression in Rat Aorta Vascular Smooth Muscle Cells Does Not Require Heterotrimeric G Protein Activation. Morinelli, T.A., Kendall,R.T., Luttrel, L.M., Walker, L.P. and Ullian, M.E. Journal of Pharmacology and Experimental Therapeutics. 330(1): 118-124, 2009.

Sustained Receptor Stimulation Leads to Sequestration of Recycling Endosomes in a cPKC and PLD-Dependent Manner.  Idkowiak-BaldysJ, Baldys A, Raymond JR, Hannun YA. J Biol Chem. 2009 Jun 11.

Epidermal growth factor activates Na(+/)H(+) exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin.  Coaxum SD, Garnovskaya MN, Gooz M, Baldys A, Raymond JR.Biochim Biophys Acta. 2009 Jul; 1793(7):1174-81.

Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor.  Baldys A, Göoz M, Morinelli TA, Lee MH, Raymond JR Jr, Luttrell LM, Raymond JR Sr. Biochemistry. 2009 Feb 24;48(7):1462-73.

ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis. Göoz P, Göoz M, Baldys A, Hoffman S. Biochem Biophys Res Commun. 2009 Feb 27; 380(1):33-8.

Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes. Holmuhamedov E, Lemasters JJ. Arch Biochem Biophys. 2009 Jan 15; 481(2):226-33.

 
 
 

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