Recent Publications:
Rodriguez-Enriquez S, Kai Y, Maldonado E, Currin RT, Lemasters JJ. Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy 2009, Nov 13; 5 (8). Epub. Lemasters JJ, Theruvath TP, Zhong Z, Nieminen AL. Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta. 2009 Nov; 1787 (11); 1395. Lemasters, J.J. (2009) Molecular mechanisms of cell death. In Molecular Pathology. The Molecular Basis of Human Disease, William B. Coleman and Gregory J. Tsongalis (Eds.), Elsevier, Amsterdam, pp. 3-24. Holmuhamedov E, Lemasters JJ (2009). Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes. Arch Biochem Biophys. 2009 Jan 15; 481(2):226-33. Epub Nov 11. PDF Nieminen, A.-L., V.K. Ramshesh, and J.J. Lemasters (2008) Use of fluorescent reporters to measure mitochondrial membrane potential and the mitochondrial permeability transition. In Mitochondrial Dysfunction in Drug-Induced Toxicity, Yvonne Will and James A. Dykens (Eds.), John Wiley & Sons, New York, pp. 413-431. Ramshesh VK, Lemasters JJ (2008). Pinhole shifting lifetime imaging microscopy. J Biomed Opt. Nov-Dec;13 (6) :064001. PDF Theruvath T, Lemasters JJ (2008). Cyclosporine in acute myocardial infarction. N Engl J Med. Nov 20;359(21):2286; author reply 2288-9. UCPs- unlikely calcium porters (2008). Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ, Brand MD. Nat Cell Biol. 2008 Nov;10(11):1235-7. author reply. Uchiyama A, Kim JS, Kon K, Jaeschke H, Ikejima K, Watanabe S, Lemasters JJ (2008) Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology. Nov;48(5):1644-54. PDF Zhong Z, Ramshesh VK, Rehman H, Currin RT, Sridharan V, Theruvath TP, Kim I, Wright GL, Lemasters JJ (2008).Activation of the Oxygen-Sensing Signal Cascade Prevents Mitochondrial Injury after Mouse Liver Ischemia-Reperfusion. Am J Physiol Gastrointest Liver Physiol. Sep 4. PDF Rehman H, Ramshesh VK, Theruvath TP, Kim I, Currin RT, Giri S, Lemasters JJ, Zhong Z (2008).NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. J Pharmacol Exp Ther. Dec;327(3):699-706. Epub 2008 Sep 18. PDF Theruvath R.T., Snoddy M.C., Zhong Z, Lemasters J.J. (2008). Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. Transplantation 85 (10), 1500-1504. PDFRehman H, Connor HD, Ramshesh VK, Theruvath TP, Mason RP, Wright GL, Lemasters JJ, Zhong Z (2008). Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation 85( 9), 1322-31. PDF
Theruvath TP, Zhong Z, Pediaditakis P, Ramshesh VK, Currin RT, Tikunov A, Holmuhamedov E, Lemasters JJ (2008) Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology 47( 1), 236-46. PDF
Lemasters JJ (2007) Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol 22 Suppl 1, S31-7. PDF Lemasters, J.J., and V.K. Ramshesh (2007) Imaging of mitochondrial polarization and depolarization with cationic fluorophores. Meth. Cell Biol. 80, 283-295. PDFZhong, Z., T.P. Theruvath, R.T. Currin, P.C. Waldmeier and J.J. Lemasters (2007) NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small- for-size rat liver grafts. Am. J. Transplant. 7, 1103-1111. PDF
Kim, I., S. Rodriguez-Enriquez and J.J. Lemasters (2007) Selective degradation of mitochondria by mitophagy. Arc. Biochem. Biophys. 462, 245–253. PDF
Malhi, H., G.J. Gores and J.J. Lemasters (2006) Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 43, S31-S44. PDF
Conzelmann, L.O., M. Lehnert, M. Kremer, Z. Zhong, M.D. Wheeler, and J.J. Lemasters (2006) Graft tumor necrosis factor receptor 1 protects after mouse liver transplantation whereas host TNFR1 promotes injury. Transplantation 82, 1214-1220. PDF
Lehnert, M., T. Uehara, B.U. Bradford, H. Lind, Z. Zhong, D.A. Brenner, I. Marzi | and J.J. Lemasters (2006) Lipopolysaccharide-binding protein modulates hepatic damage and the intracellular stress response after hemorrhagic shock and resuscitation. Am. J. Physiol. 291, G456-G463. PDF
Kim, J.-S., Y. Jin, and J.J. Lemasters (2006) Reactive oxygen species, but not Ca 2+, trigger pH- and mitochondrial permeability transition-dependent killing of adult rat myocytes after ischemia/reperfusion. Am. J. Physiol. 290, H2024-H2034. PDFZhong, Z., R.F. Schwabe, Y. Kai, L. He, L. Yang, H. Bunzendahl, D.A. Brenner and J. J. Lemasters (2006) Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation 82, 241-250. PDF
Lemasters, J.J., and E. Holmuhamedov (2006) Voltage-dependent anion channel (VDAC) as mitochondrial governator – thinking outside the box. Biochim. Biophys. Acta 1762, 181-190. PDFRodriguez-Enriquez, S., I. Kim, R.T. Currin and J.J. Lemasters (2006) Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2, 39-46. PDF |
