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Center for Cell Death, Injury and Regeneration


Recent Publications:

Kholmukhamedov A, Spinale FG, Mukherjee R, Lemasters JJ. Reply to Letter to the editor: Cyclosporin A in left ventricular remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2014 Mar;306(5): H778-9. 

Kholmukhamedov A, Logdon C, Hu J, McKinney RA, Spinale FG, Lemasters JJ, Mukherjee R.Am J Physiol Heart Circ Physiol. Cyclosporin A in left ventricular remodeling after myocardial infarction.. 2014 Jan 1;306(1):H53-9. Epub 2013 Oct 25.

Zhong Z, Ramshesh VK, Rehman H, Liu Q, Theruvath TP, Krishnasamy Y, Lemasters JJ. Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism.PLoS One. 2014 Mar 11;9(3):e91308.

Schwartz J, Holmuhamedov E, Zhang X, Lovelace GL, Smith CD, Lemasters JJ.  Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter.Appl Pharmacol. 2013 Nov 15;273(1):172-9. doi: 10.1016/j.taap.2013.08.027. Epub 2013 Sep 5.

Zhang X, Lemasters JJ. Translocation of iron from lysosomes to mitochondria during ischemia predisposes to injury after reperfusion in rat hepatocytes. Free Radic Biol Med. 2013 Oct;63:243-53. doi: 10.1016/j.freeradbiomed.2013.05.004. Epub 2013 May 9.

Czaja MJ, Ding WX, Donohue TM Jr, Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JH, Perlmutter DH, Randall G, Ray RB, Tsung A, Yin XM. Functions of autophagy in normal and diseased liver.Autophagy. 2013 Aug;9(8):1131-58.

He S, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Schnellmann RG, Zhong Z. Suramin Decreases Injury and Improves Regeneration of Ethanol-Induced Steatotic Partial Liver Grafts. J Pharmacol Exp Ther. 2013 Feb; 344(2):417-425. Epub 2012 Nov 16.

Hung HI, Schwartz JM, Maldonado EN, Lemasters JJ, Nieminen AL. Mitoferrin-2-dependent Mitochondrial Iron Uptake Sensitizes Human Head and Neck Squamous Carcinoma Cells to Photodynamic Therapy. J Biol Chem. 2013 Jan 4;288(1):677-86.

Woolbright BL, Ramachandran A, McGill MR, Yan HM, Bajt ML, Sharpe MR, Lemasters JJ, Jaeschke H. Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity. Basic Clin Pharmacol Toxicol. 2012 Dec;111(6):417-25.

Kholmukhamedov A, Schwartz JM, Lemasters JJ.Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats: mitotracker probes and mitochondrial membrane potential. Shock. 2013 Jun;39(6):543. doi: 10.1097/SHK.0b013e318292300d.

Kholmukhamedov A, Schwartz JM, Lemasters JJ. Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem. 2013 Apr 26;288(17):11920-9.

Currin RT, Peng XX, Lemasters JJ. Ischemic preconditioning of rat livers from non-heart-beating donors decreases parenchymal cell killing and increases graft survival after  transplantation. HPB Surg. 2012;2012:236406. Epub 2012 Jul 19.

Liu Q, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Smith CD, Zhong Z. Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One. 2012;7(7):e41834. Epub 2012 Jul 25.

Czerny C, Theruvath TP, Maldonado EN, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. C-Jun N-Terminal Kinase 2 Promotes Liver Injury via the Mitochondrial Permeability Transition after Hemorrhage and Resuscitation. HPB Surg. 2012;2012:641982. Epub 2012 Jun 27.

Theruvath TP, Ramshesh VK, Zhong Z, Currin RT, Karrasch T, Lemasters JJ. Icam-1 upregulation in ethanol-induced Fatty murine livers promotes injury and sinusoidal leukocyte adherence after transplantation. HPB Surg. 2012;2012:480893. Epub 2012 Jun 18.

Czerny C, Kholmukhamedov A, Theruvath TP, Maldonado EN, Ramshesh VK, Lehnert M, Marzi I, Zhong Z, Lemasters JJ. Minocycline decreases liver injury after hemorrhagic shock and resuscitation in mice. HPB Surg. 2012;2012:259512. Epub 2012 Jun

Maldonado EN, Lemasters JJ. Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells. J Pharmacol Exp Ther. 2012 Sep;342(3):637-41. Epub 2012 Jun 13. Review.

Liu Q, Rehman H, Krishnasamy Y, Haque K, Schnellmann RG, Lemasters JJ, Zhong Z. Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. Am J Transplant. 2012 Aug;12(8):2052-61. Epub 2012 Jun

Liu Q, Rehman H, Harley RA, Lemasters JJ, Zhong Z. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811. HPB Surg. 2012;2012:270372. Epub 2012 May 22.

Liu Q, Rehman H, Krishnasamy Y, Ramshesh VK, Theruvath TP, Chavin KD, Schnellmann RG, Lemasters JJ, Zhong Z. Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers. Free Radic Biol Med. 2012 Jul 15;53(2):250-9. Epub 2012 May 15.

Dolganiuc A, Thomes PG, Ding WX, Lemasters JJ, Donohue TM Jr. Autophagy in alcohol-induced liver diseases. Alcohol Clin Exp Res. 2012 Aug;36(8):1301-8. Epub 2012 May 2. Review.

Saggu S, Hung HI, Quiogue G, Lemasters JJ, Nieminen AL. Lysosomal signaling enhances mitochondria-mediated photodynamic therapy in A431 cancer cells: role of iron. Photochem Photobiol. 2012 Mar-Apr;88(2):461-8. Epub 2012 Jan 25.

Holmuhamedov EL, Czerny C, Beeson CC, Lemasters JJ. Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. J Biol Chem. 2012 Mar 2;287(10):7692-700. Epub 2012 Jan 6.

Lemasters JJ, Holmuhamedov EL, Czerny C, Zhong Z, Maldonado EN. Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect. Biochim Biophys Acta 2011 Dec 7.  PMID:22172804

Ramshesh VK, Lemasters JJ.Imaging of mitochondrial pH using SNARF-1. Methods Mol Biol. 2012;810:243-8.PMID:22057572

Sheldon KL, Maldonado EN, Lemasters JJ, Rostovtseva TK, Bezrukov SM.Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS One. 2011;6(10):e25539. Epub 2011 Oct 13.

Shi Y, Rehman H, Ramshesh VK, Schwartz J, Liu Q, Krishnasamy Y, Zhang X, Lemasters JJ, Smith CD, Zhong Z.J Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. J Hepatol. 2012 Jan;56(1):137-45. Epub 2011 Jul 12.PMID:21756852

Bajt ML, Ramachandran A, Yan HM, Lebofsky M, Farhood A, Lemasters JJ, Jaeschke H. Toxicol Sci. 2011 Aug;122(2):598-605.Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.  Toxicol Sci. 2011 Aug;122(2):598-605. Epub 2011 May 13.PMID:21572097

Rehman H, Sun J, Shi Y, Ramshesh VK, Liu Q, Currin RT, Lemasters JJ, Zhong Z. NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy. Transplantation. 2011 Feb 27;91(4):406-12. PMID: 21131897.

Kim I, Lemasters JJ. Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal. 2011 May 15;14(10):1919-28. Epub 2011 Mar 6. PMID: 21126216

Kim I, Lemasters JJ. Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation. Am J Physiol Cell Physiol. 2011 Feb;300(2):C308-17. Epub 2010 Nov 24. PMID: 21106691.

Ramachandran A, Lebofsky M, Baines CP, Lemasters JJ, Jaeschke H. Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury. Free Radic Res. 2011 Feb;45(2):156-64. Epub 2010 Oct 13. PMID: 20942566.

Pediaditakis P, Kim JS, He L, Zhang X, Graves LM, Lemasters JJ (2010). Inhibition of the Mitochondrial Permeability Transition by Protein Kinase A in Rat Liver Mitochondria and Hepatocytes.Biochem J. 2010 Aug 26. PDF

Lenert M, Linnd H, Zhong Z, Schoonhoven R, Marzi I, Lemasters JJ (2010). Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats. BMC Complement Altern Med. 2010 Aug 24;10:46. PDF

Yan HM, Ramachandran A, Bajt ML, Lemasters JJ, Jaeschke H (2010).The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes. Toxicol Sci. 2010 Oct;117(2):515-23. PDF

Kon K, Kim JS, Uchiyama A, Jaeschke H, Lemasters JJ (2010). Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci. 2010 Sep;117(1):101-8. PDF

Quiogue G, Saggu S, Hung HI, Kenney ME, Oleinick NL, Lemasters JJ, Nieminen AL.Signaling From Lysosomes Enhances Mitochondria-Mediated Photodynamic Therapy In Cancer Cells. Proc Soc Photo Opt Instrum Eng. 2009 Jul 12.

Zong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA, Brenner DA, Lemasters JJ.Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Liver Transpl. 2010 Feb;16(2):181-90.PDF

Tikunov A, Johnson CB, Pediaditakis P, Markevich N, Macdonald JM, Lemasters JJ, Holmuhamedov E.Closure of VDAC causes oxidative stress and accelerates the Ca(2+)-induced mitochondrial permeability transition in rat liver mitochondria. Arch Biochem Biophys. 2010 Mar 15;495(2):174-81. Epub 2010 Jan 25. PDF

Rodriguez-Enriquez S, Kai Y, Maldonado E, Currin RT, Lemasters JJ (2010). Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy 2009, Nov 13; 5 (8).

Lemasters JJ, Theruvath TP, Zhong Z, Nieminen AL (2010). Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta. 2009 Nov; 1787 (11); 1395.  

Lemasters, J.J. (2009) Molecular mechanisms of cell death. In Molecular Pathology. The Molecular Basis of Human Disease, William B. Coleman and Gregory J. Tsongalis (Eds.), Elsevier, Amsterdam, pp. 3-24.

Holmuhamedov E, Lemasters JJ (2009). Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes. Arch Biochem Biophys. 2009 Jan 15; 481(2):226-33. Epub Nov 11. PDF

Nieminen, A.-L., V.K. Ramshesh, and J.J. Lemasters (2008) Use of fluorescent reporters to measure mitochondrial membrane potential and the mitochondrial permeability transition. In Mitochondrial Dysfunction in Drug-Induced Toxicity, Yvonne Will and James A. Dykens (Eds.), John Wiley & Sons, New York, pp. 413-431.

Ramshesh VK, Lemasters JJ (2008). Pinhole shifting lifetime imaging microscopy. J Biomed Opt. Nov-Dec;13 (6) :064001. PDF

Theruvath T, Lemasters JJ (2008). Cyclosporine in acute myocardial infarction. N Engl J Med. Nov 20;359(21):2286; author reply 2288-9.

Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ, Brand MD. UCPs- unlikely calcium porters (2008).  Nat Cell Biol. 2008 Nov;10(11):1235-7. Author reply.

Uchiyama A, Kim JS, Kon K, Jaeschke H, Ikejima K, Watanabe S, Lemasters JJ (2008) Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury. Hepatology. Nov;48(5):1644-54. PDF 

Zhong Z, Ramshesh VK, Rehman H, Currin RT, Sridharan V, Theruvath TP, Kim I, Wright GL, Lemasters JJ (2008).Activation of the Oxygen-Sensing Signal Cascade Prevents Mitochondrial Injury after Mouse Liver Ischemia-Reperfusion. Am J Physiol Gastrointest Liver Physiol. Sep 4. PDF 

Rehman H, Ramshesh VK, Theruvath TP, Kim I, Currin RT, Giri S, Lemasters JJ, Zhong Z (2008). NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice. J Pharmacol Exp Ther. Dec;327(3):699-706. Epub 2008 Sep 18. PDF

Theruvath R.T., Snoddy M.C., Zhong Z, Lemasters J.J. (2008). Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. Transplantation 85 (10), 1500-1504. PDF

Rehman H, Connor HD, Ramshesh VK, Theruvath TP, Mason RP, Wright GL, Lemasters JJ, Zhong Z (2008). Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation 85(9), 1322-31. PDF

Theruvath TP, Zhong Z, Pediaditakis P, Ramshesh VK, Currin RT, Tikunov A, Holmuhamedov E, Lemasters JJ (2008)  Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology 47(1), 236-46. PDF

Lemasters JJ (2007) Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J Gastroenterol Hepatol 22 Suppl 1, S31-7. PDF

Lemasters, J.J., and V.K. Ramshesh (2007) Imaging of mitochondrial polarization and depolarization with cationic fluorophores. Meth. Cell Biol. 80, 283-295. PDF

Zhong, Z., T.P. Theruvath, R.T. Currin, P.C. Waldmeier and J.J. Lemasters (2007) NIM811, a mitochondrial permeability transition inhibitor, prevents mitochondrial depolarization in small- for-size rat liver grafts. Am. J. Transplant. 7, 1103-1111. PDF

Kim, I., S. Rodriguez-Enriquez and J.J. Lemasters (2007) Selective degradation of mitochondria by mitophagy. Arc. Biochem. Biophys. 462, 245–253. PDF

Malhi, H., G.J. Gores and J.J. Lemasters (2006) Apoptosis and necrosis in the liver: a tale of two deaths? Hepatology 43, S31-S44. PDF

Conzelmann, L.O., M. Lehnert, M. Kremer, Z. Zhong, M.D. Wheeler, and J.J. Lemasters (2006) Graft tumor necrosis factor receptor 1 protects after mouse liver transplantation whereas host TNFR1 promotes injury. Transplantation 82, 1214-1220. PDF

Lehnert, M., T. Uehara, B.U. Bradford, H. Lind, Z. Zhong, D.A. Brenner, I. Marzi| and J.J. Lemasters (2006) Lipopolysaccharide-binding protein modulates hepatic damage and the intracellular stress response after hemorrhagic shock and resuscitation. Am. J. Physiol. 291, G456-G463. PDF

Kim, J.-S., Y. Jin, and J.J. Lemasters (2006) Reactive oxygen species, but not Ca2+, trigger pH- and mitochondrial permeability transition-dependent killing of adult rat myocytes after ischemia/reperfusion. Am. J. Physiol. 290, H2024-H2034. PDF

Zhong, Z., R.F. Schwabe, Y. Kai, L. He, L. Yang, H. Bunzendahl, D.A. Brenner and J. J. Lemasters (2006) Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation 82, 241-250. PDF

Lemasters, J.J., and E. Holmuhamedov (2006) Voltage-dependent anion channel (VDAC) as mitochondrial governator – thinking outside the box. Biochim. Biophys. Acta 1762, 181-190. PDF

Rodriguez-Enriquez, S., I. Kim, R.T. Currin and J.J. Lemasters (2006) Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2, 39-46. PDF

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