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Partnering with SCCTDD


The South Carolina Compound Collection (SC3)

Building a chemically diverse Therapeutic Screening Library

The South Carolina Compound Collection (SC3), which is comprised of small, drug-like molecules that can be used in biological screens to identify starting points for drug discovery projects. The goal in creating this library is to offer an in-house collection of validated analogues that are representative of the best compounds made by academic and industrial chemists in South Carolina. There are no restrictions on the chemical properties of these compounds (molecular weight, hydrogen bond donors and acceptors, cLogP, etc.) because the goal is to maintain a collection with high chemical diversity. Compounds are added to the collection through commercial purchases, donations of compound collections from South Carolina academic and industrial sites, and samples from researchers at MUSC and USC. All compounds are annotated and stored in the searchable SC3 database along with any associated physical and biological data. All researchers that contribute compounds to the SC3 will receive an annual report that contains the screening data for their respective compounds.

Currently the SC3 includes over 120,000 unique compounds of highly diverse and proprietary chemistry.  The SC3 was founded on the inaugural donation of over 2000 compounds from Charles F. Beam, Jr., Ph.D., Emeritus Professor of Chemistry at the College of Charleston.  The second major addition to the SC3 was the donation of over 100,000 compounds from the Æterna Zentaris discovery library.