Building a chemically diverse Therapeutic Screening Library
The South Carolina Compound Collection (SC3), which is comprised of small, drug-like molecules that can be used in biological screens to identify starting points for drug discovery projects. The goal in creating this library is to offer an in-house collection of validated analogues that are representative of the best compounds made by academic and industrial chemists in South Carolina. There are no restrictions on the chemical properties of these compounds (molecular weight, hydrogen bond donors and acceptors, cLogP, etc.) because the goal is to maintain a collection with high chemical diversity. Compounds are added to the collection through commercial purchases, donations of compound collections from South Carolina academic and industrial sites, and samples from researchers at MUSC and USC. All compounds are annotated and stored in the searchable SC3 database along with any associated physical and biological data. All researchers that contribute compounds to the SC3 will receive an annual report that contains the screening data for their respective compounds.