For FY07 CHEPS team members had twenty-two ongoing funded research projects totaling nearly $10.60 million in total awards on which they serve as the Principal Investigator. This funding includes federal, state, and foundation grants. The main focus areas of funded research for CHEPS faculty are 1) direct to consumer advertising for prescription drugs; 2) hospital financing and quality of care; 3) spinal cord injuries; 4) cancer management; 5) substance abuse; and 6) pharmacoeconomic modeling of pharmaceuticals for the treatment HIV. Funded Grant Details – CHEPS faculty as PI W. David Bradford, Ph.D. - DTC Advertising Effect on Adherence to Statin Therapy
Source: NIH/ National Heart, Lung & Blood Institute Total Award: $714,520 The goal of this research is to determine if patients who live in areas where pharmaceutical therapy for hyperlipidemia (statins) are heavily advertised have better adherence to their prescription therapy than patients who live in areas where these drugs are not advertised, and as a consequence have better outcomes.
- 17th Annual Health Economics Conference
Source: DHHS/Agency for Healthcare Research and Quality Total Award: $36,000 The goals of this conference are to (1) advance the policy applicability of health economics; (2) improve the policy relevance of empirical health economics; and (3) develop the next generations of health economic scholars.
- Estimation of the Cost-effectiveness and Budgetary Impact of Sutent in Portugal using the Treatment of Metastic Renal Cell Carcinoma (mRCC) Model
Source: Datamedica (UMA Contract) Total Award: $37,500 The goal of this project is to assess the financial impact and health improvements of introducing a new cancer supplemental therapy to the Portuguese Health System.
- The Financial and Clinical Efficacy of Mirena: An Investigation of Cost-offsets Derived from the Effects of Mirena on Pregnancy Prevention and the Treatment of Menorrhagia
Source: Bayer Healthcare Pharmaceuticals, Inc. Total Award: $70,000 The project goal is to estimate the clinical efficacy and potential cost offsets for state Medicaid programs from increased Mirena utilization.
- Effect of FDA Boxed Warnings and Public Information on Pharmaceutical Use
Source: DHHS/Agency for Healthcare Research and Quality Total Award: $1,172,609 The aims of this project are to examine: 1) the effects of public information and black box warnings on the flow of patients into physician offices, 2) the effects of public information on the likelihood of appropriate drug prescribing, and 3) examine the impact of FDA issued boxed warning on the likelihood of appropriate prescribing for specific medications.
G. John Chen, M.D., Ph.D. Source: Veterans Administration, VISN Research Career Development Award Total Award: $57,000 The goal is to examine racial difference in quality of care, clinical outcome, and utilization among veteran patients with chronic kidney diseases.
Clara (Libby) E. Dismuke, Ph.D. Source: State of South Carolina Spinal Cord Injury Research Fund Board Total Award: $79,995 The goal of the project is to determine how family socio- economic, personal and medical characteristics affect the decision regarding return to employment of the individual with spinal cord injury and the acquisition of total household income.
Douglas L. Leslie, Ph.D. Source: NIH/National Institute for Mental Health Total Award: $302,872 This grant supports secondary dataset analyses (private and Medicaid sources) aimed at understanding time trends and priorities associated with the costs of care for autism and related disorders.
Richard C. Lindrooth, Ph.D. Source: DHHS/Agency for Healthcare Research and Quality Total Award: $552,358 This project focuses on the determinants of decisions about hospital service offerings and the effect of such decisions on patients, competing hospital’s financial performance and social welfare.
Source: Berlex Laboratories Total Award: $132,081 The first phase of this project is designed to measure the effect of Medicaid coverage of contraception on unplanned pregnancies. The second phase focuses on the utilization of Berlex’s products in the California Medicaid market.
Source: NIH/National Institute of Mental Health Total Award: $576,957 The goal of this project is to investigate how the probability that an existing inpatient psychiatric facility closes is affected by industry-specific trends in reimbursement and demand for care; market-specific conditions such as managed care, government policies, the political climate or closure of a competitor; or hospital-specific factors such as case-mix or payer-mix.
Source: Robert Wood Johnson Foundation Total Award: $299,020 This project proposes to examine both efforts to improve patient safety and actual changes in measures of patient safety.
Patrick D. Mauldin, Ph.D. Source: University of South Carolina Research Foundation & South Carolina Department of Health and Human Services (MUSC Subcontract) Total Award: $112,742 (MUSC Subcontract, Year One) The goal of this $1.98 million grant is to implement an educational outreach program to improve the drug therapy regimens of Medicaid beneficiaries diagnosed with mental health disorders, HIV/AIDS or cancer. The study aims to facilitate prescribing clinically-appropriate, cost- effective medications, and limit usage of high cost or less safe alternative medicines.
Ashli J. Sheidow, Ph.D. Source: NIH/National Institute of Drug Abuse Total Award $718,460 The training plan learning objectives are: (1) Gain familiarity with validated outpatient treatments for adolescent substance abuse. (2) Develop knowledge of and experience with conducting randomized clinical trials. (3) Learn and utilize state-of-the-art statistical methods for evaluating treatment outcomes.
Source: NIH/National Institute of Drug Abuse Total Award $382,826 The primary aim of the present research is to adapt and test MST for use in outpatient settings to treat youth diagnosed with a substance use disorder and comorbid internalizing disorder.
Gerard A. Silvestri, M.D. Source: Emphasys Medical, Inc. Total Award: $198,951 The purpose of this study is to assess the safety and efficacy of the Emphasys Endobronchial Valve (EBV) and procedure (with pulmonary rehabilitation) compared to optimal medical management (with pulmonary rehabilitation) in patients with heterogeneous emphysema.
A Phase 3, Randomized, Double-Blind, Dose Controlled Study to Assess the Efficacy and Safety of Aquavan (Fospropofol Disodium) Injection for Minimal-To-Moderate Sedation in Patients Undergoing Flexible Bronchoscopy.
Source: MGI Pharma Total Award: $73,784 This is a clinical trial to determine the optimal AQUAVAN injection dose for providing minimal-to-moderate sedation in patients undergoing flexible bronchoscopy compared to a subtherapeutic dose of AQUAVAN.
Source: Department of Defense Total Award: $4,275,352 This goals of this project are to (1) develop improved computer-aided detection (CAD) software to aid in identifying lesions and differentiating between benign and malignant nodules based on CT findings, (2) to test the CAD software against independent readers in clinically significant scenarios, and (3) to utilize clinical and radiologic findings from patients with indeterminate CT detected nodules to produce a prediction model to improve the ability to differentiate benign from malignant disease.
Source: Department of Defense Total Award: $1,765,000 This project is comprised of seven additional studies that contribute to the management of patients with lung cancer and provide crucial details to the original grant in the following areas: (1) Development and Testing of Multivariate Statistical Predication Model of Malignancy Potential of Small (< 1.5cm) Pulmonary Nodules; (2) Use of Molecular Markers of Malignancy to Identify Pre-malignant Lesions in Bronchial Samples Identified using Narrow Band Imaging (NBI) Bronchoscopy; (3) Optimization of PET/CT for Evaluation of the Indeterminate Pulmonary Nodule; (4) A Simple Two-Gene Expression Ratio as a Strong Prognostic Indicator of Clinical Outcome in Early Stage Adenocarcinoma of the Lung; (5) Comparing Endobrachial and Endoscopic Ultrasound-guided FNA to Mediastinoscopy in the Staging and Early Detection of Metastases in Lung Cancer; (6) State Use of Master Settlement Agreement Funds; and (7) Public Health and Economic Implications of Free Nicotine Replacement.
Source: Federal Flow-down from Stanford University/LSJU Total Award: $15,076 The goal of the research is to develop a computerized tool which will help clinicians decide which testing to perform when patients present with solitary pulmonary nodules.
Kit N. Simpson, Dr. PH. Source: Boehringer Ingleheim Pharmaceuticals, Inc. Total Award: $216,800 The goal of the project is to design two piggy-back economic and quality of life studies to complement Phase III clinical trial data collection in multinational studies in Europe, North and South America, South Africa, and Australia, and to perform the economic analysis required for approval and pricing in nine countries.
Source: Abbott Laboratories Total Award: $52,000 The goals of the study are to (1) prepare a literature review of clinical trial and hazard rates in HIV needed for the new model, and (2) provide a draft analysis of the database programming required for the new model to be developed using ARENA software.
Source: Abbott Laboratories Total Award: $121,000 The objectives are to (1) develop an updated pharmacoeconomic model for the new tablet formulation of Kaletra versus Atazanavir boosted with ritonavir and efavirenz in treating antiretroviral experienced HIV patients, and (2) create two abstracts and two papers regarding the new model, and (3) draft a manuscript for submission to a peer-reviewed journal.
Source: Exponent, Inc. Total Award: $96,249 The hypothesis of this study is that the dietary supplement Supritol, an amino acid and protein formulation, combined with a calorie controlled diet and an exercise program will reduce body weight and percent body fat compared to a placebo.
Source: Neuronetics, Inc. Total Award: $53,400 The goal of this modeling study is to capture all the differences in the downstream economic impacts for TMS-treated patients, as compared to drug therapy patients.
Source: MUSC Clinical and Translational Science Implementation Office Total Award: $38,521 The purpose of this study is to identify (1) the problems related to lack of use of alteplase (tPA), a major drug treatment for acute stroke, in South Carolina, and (2) the expected change in patient outcomes, hospital budgets, and overall cost of stroke if barriers to tPA use were attenuated.
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