Michael Saladin

Michael E. Saladin, PhD

Michael E. Saladin, PhD
Professor
Department of Health Science and Research
77 President St. MSC 700
Charleston, SC 29425

Phone: (843) 792-5306
Fax: (843) 792-5306
E-mail: saladinm@musc.edu

Download full curriculum vitae.

Education

  • Ph.D., Clinical Psychology, University of Manitoba, Winnipeg, Manitoba (1992)
  • M.A., Psychology, University of Manitoba, Winnipeg, Manitoba (1987)
  • B.A., (Honors.), Psychology, University of Manitoba, Winnipeg, Manitoba (1984)

Areas of Teaching

  • Research methods and psychopathology

Research Interests

  • My current research interests focus on the learning/memory mechanisms involved in addictive behavior and the interface between stress, PTSD and substance use disorders. An additional research interest is in the area of gender differences in nicotine addiction, with special emphasis on the potential modulatory role of reproductive hormones on smoking behavior/cessation in nicotine dependent women/men.
  • Alcohol Addiction
  • Tobacco Addiction
  • Cocaine Addiction
  • Learning
  • Memory
  • Addictions
  • Stress
  • Anxiety
  • PTSD
  • Gender

Publications

  1. Gray, K. M., DeSantis, S. M., Carpenter, M. J., Saladin, M. E., LaRowe, S. D., & Upadhyaya, H. P. (in press). Menstrual Cycle and Cue Reactivity in Women Smokers. Nicotine and Tobacco Research.
  2. Price, K. L., McRae, A. L., Saladin, M. E., Moran-Santa Maria, M. M., DeSantis, S. M., Back, S. E. & Brady, K. T. (in press). D-cycloserine and Cocaine Cue Reactivity: Preliminary Findings. American Journal on Drug and Alcohol Abuse.
  3. Connolly, K. M., Coffey, S. F., Baschnagel, J. S., Drobes, D. J. & Saladin, M. E. (in press). Evaluation of the Alcohol Craving Questionnaire factor structures:  Application of a cue reactivity paradigm. Drug and Alcohol Dependence.
  4. Brady, K. T., Turek, P., Back, S. E., Saladin, M. E., Waldrop, A. E., and Myrick, H. (in press). Combat PTSD and Substance Use Disorders. Journal of Addiction Medicine. NIHMSID: NIHMS117897.  
  5. Saladin, M. E., Back, S. E., and Payne, R. A. (2009).  Post-traumatic stress disorder and substance use disorder comorbidity. In R. Ries, D. Fiellin, S. Miller, & R. Saitz (Eds.). Principles of Addiction Medicine (Fourth Edition). Baltimore, MD: Lippincott, Williams, & Wilkins.
  6. Carpenter, M. J., Saladin, M. E., DeSantis, S. M. Gray, K. M., LaRowe, S. D., & Upadhyaya, H. P. (2009). Laboratory-based, cue-elicited craving and cue reactivity as predictors of naturally occurring smoking behavior. Addictive Behavior, 34, 536-541.
  7. Rash, C. J., Coffey, S. F., Baschnagel, J. S., Drobes, D. J. & Saladin, M. E. (2008). Psychometric Properties of the IES-R in Traumatized Substance Dependent Individuals with and without PTSD. Addictive Behaviors, 33, 1039-1047. 
  8. Baschnagel, J. S., Coffey, S. F., Schumacher, J. A., Drobes, D. J. & Saladin, M. E. (2008). Relationship between PTSD symptomatology and nicotine dependence severity in crime victims. Addictive Behaviors, 33, 1441-1447.
  9. Back, S. E., Waldrop, A. E., Saladin, M. E., Yeatts, S. D., Simpson, A., McRae, A. L., Upadhyaya, H. P., Sisson, R. C., Spratt, E. G., Allen, J., Kreek, M. J., & Brady, K. T. (2008). Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation. Psychoneuroendocrinology, 33(5), 560-568.
  10. Carpenter, M. J., Saladin, M. E., Leinbach, A. S., LaRowe, S. D. & Upadhyaya, H. P. (2008). Menstrual phase effects on smoking cessation: A pilot clinical trial. Journal of Women’s Health, 17, 293-301.
  11. Waldrop, A. E., Back, S. E., Brady, K. T., Upadhyaya, H. P., McRae, A. L., Saladin, M. E. (2007). Daily stressor sensitivity, abuse effects, and cocaine use in cocaine dependence. Addictive Behaviors, 32, 3015-3025.
  12. LaRowe, S. D., Saladin, M. E., Carpenter, M. J. & Upadhyaya, H. P. (2007). Reactivity to nicotine cues over repeated cue reactivity sessions. Addictive Behaviors, 32, 2888-2899. 
  13. LaRowe, S., Myrick, H., Hedden, S., Mardikian, P., Saladin, M., McRae, A., Brady, K., Kalivas, P. & Malcolm, R. (2007). Is cocaine desire reduced by N-Acetylcysteine? American Journal of Psychiatry, 164, 1115-1117.
  14. McRae, A. L., Saladin, M. E., Brady, K. T., Timmerman, M. A., & Upadhyaya, H. P.  (2006). Stress reactivity: Biologic and subjective responses to the cold pressor and Trier social stressors. Human Psychopharmacology, 21(6), 377-385.
  15. Brady, K. T., Back, S. E., Waldrop, A. E., McRae, A. L., Anton, R. F., Upadhyaya, H. P., Saladin, M. E. and Randall, P. K. (2006).  Cold pressor task reactivity:  Predictors of alcohol use among alcohol dependent individuals with and without comorbid posttraumatic stress disorder.  Alcoholism:  Clinical and Experimental Research, 30, 938-946.
  16. Saladin, M. E., Brady, K. T., Graap, K. M., & Rothbaum, B. O. (2006). A preliminary report on the use of virtual reality technology to elicit craving and cue reactivity in cocaine dependent individuals. Addictive Behaviors, 31, 1881-1894.
  17. Brady, K.T., Waldrop, A. E., McRae, A.L., Back, S. E., Saladin, M.E., Upadhyaya, H. P., Anton, R.F., & Randall, P. K. (2006). The impact of alcohol dependence and post-traumatic stress disorder on cold pressor task response. Journal of Studies on Alcoholism, 67(5), 700-706.
  18. Santa Ana, E. J., Saladin, M. E., Back, S. E., Waldrop, A. E., Spratt, E. G., McRae, A. L., LaRowe, S. D., Timmerman, M. A., Upadhyaya, H., & Brady, K.T., (2006). PTSD and the HPA axis: Differences in response to the cold pressor task among individuals with child vs. adult trauma. Psychoneuroendocrinology, 31, 501–509.
  19. Carpenter, M. J., Upadhyaya, H. P., LaRowe, S. D., Saladin, M. E. & Brady, K. T. (2006).  Menstrual cycle phase effects on nicotine withdrawal and cigarette craving:  A Review. Nicotine and Tobacco Research, 8(5), 627-638.
  20. LaRowe, S. D., Mardikian, P., Malcolm, R., Myrick, H., Kalivas, P., McFarland, K., Saladin, M., McRae, A., Brady, K. (2006). Safety and Tolerability of N‑Acetylcysteine in Cocaine-Dependent Individuals. The American Journal on Addictions, 15, 105-110.
  21. Petry, N.M., Peirce, J. M., Stitzer, M. L., Blaine, J., Roll, J. D., Cohen, A., Obert, J., Stabile, P. Q., Killeen, T., Saladin, M. E., Cowell, M., Kirby, K., Sterling, R., Royer-Malvestuto, C., Hamilton, J., Booth, B., MacDonald, M., Liebert, M., Rader, L., Burns, R., DiMaria, J., Copersino, M., Kolodner, K. and Li, R.  (2005) Effects of prize-based incentives on outcomes stimulant abusers in outpatient psychosocial treatment programs:  A National Drug Abuse Treatment Clinical Trials Network Study.  Archives of General Psychiatry, 62, 1148-1156.
  22. Drobes, D. J., Munafò, M. R., Leigh, F., Saladin, M. E. (2005). A family smoking index to capture genetic influence in smoking:  Rationale and two validation studies. Nicotine & Tobacco Research, 7, 41-46.
  23. Morrisette, D. C., Brown, D. & Saladin, M. E. (2004). Temperature Change in Lumbar Periarticular Tissue with Continuous Ultrasound. Journal of Orthopaedic and Sports Physical Therapy, 34, 754-760.
  24. Saladin, M. E. & Santa Ana, E. J. (2004).  Controlled drinking: More than just a controversy.  Current Opinion in Psychiatry, 17(3), 175-187.
  25. Saladin, M. E., Drobes, D. J., Coffey, S. F., Dansky, B. S., Brady, K. T. & Kilpatrick, D. G. (2003).  PTSD symptom severity as a predictor of cue-elicited drug craving in victims of violent crime.  Addictive Behaviors, 28, 1611-1629.
  26. Parrott, D.J., Drobes, D.J., Saladin, M.E., Coffey, S.F., & Dansky, B.S. (2003). Perpetration of partner violence: Effects of cocaine and alcohol dependence and post-traumatic stress disorder. Addictive Behaviors, 28, 1587-1602.
  27. Coffey, S. F., Gudleski, G., Saladin, M. E., & Brady, K. T. (2003).  Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals. Experimental and Clinical Psychopharmacology, 11(1), 18-25.
  28. Saladin, M. E., Drobes, D. J., Coffey, S. F., & Libet, J. M. (2002).  The human startle reflex and alcohol cue reactivity:  Effects of early versus late abstinence. Psychology of Addictive Behavior, 16, 98-105.
  29. Coffey, S.F., Saladin, M.E., Drobes, D.J., Brady, K.T., Dansky, B.S., & Kilpatrick, D.G.  (2002).  Trauma and substance cue reactivity in individuals with comorbid posttraumatic stress disorder and cocaine or alcohol dependence.  Drug and Alcohol Dependence, 65, 115-127.
  30. Drobes, D. J., Saladin, M. E., & Tiffany, S. T. (2001).  Classical conditioning mechanisms in alcohol dependence.  In N. Heather, T. J. Peters, & T. Stockwell (Eds.), International handbook of alcohol dependence and problems (pp. 281-297).  Chichester: John Wiley & Sons.
  31. Back, S., Dansky, B. S., Coffey, S. F., Saladin, M. E., Sonne, S. C., & Brady, K. T. (2000). Cocaine dependence with and without posttraumatic stress disorder: A comparison of substance use, trauma history, and psychiatric comorbidity. American Journal on Addictions, 9, 51-62.
  32. Coffey, S. F., Saladin, M. E., Libet, J., Drobes, D. J., & Dansky, B. S. (1999).  Differential urge and salivary responsivity to alcohol cues in alcohol dependent patients: A comparison of traditional and stringent classification approaches. Experimental and Clinical Psychopharmacology, 7, 464-472.
  33. Clure, C, Brady, K. T., Saladin, M. E., Johnson, D. Waid, R. & Rittenbury, M. (1999). Attention-deficit hyperactivity disorder and substance use:  Symptom pattern and drug choice.  The American Journal of Drug and Alcohol Abuse, 25(3), 441-448.
  34. Dansky, B. S. Brady, K. T. Saladin, M. E. (1998).  Untreated symptoms of PTSD among cocaine dependent individuals:  Changes over time. Journal of Substance Abuse Treatment, 15, 499-504
  35. Brady, K. T., Dansky, B. S., Saladin, M. E. & Sonne, S. C. (1998). Post-traumatic stress disorder and cocaine dependence:  Order of onset. American Journal on Addictions, 7, 128-135. 
  36. Coffey, S. F., Dansky, B. S., Falsetti, S. A., Saladin, M. E.,  & Brady, K. T. (1998).  Screening for PTSD in a substance abuse sample:  Psychometric Properties of a Modified Version of the PTSD Symptom Scale Self-Report. Journal of Traumatic Stress, 11, 393-399. 
  37. Mintzer, J. E., Colenda, C., Waid, L. R., Lewis, L., Meeks, A., Stuckey. M., Bachman, D. L., Saladin, M. E., Sampson, R. R. (1997).  Effectiveness of a continuum of care model for agitated dementia patients. Psychiatric Services, 48, 1435-1439.
  38. Dansky, B. S., Saladin, M. E., Coffey, S. F. & Brady, K. T. (1997).  Use of self-report measures of crime-related posttraumatic stress disorder with substance use disordered patients. Journal of Substance Abuse Treatment, 14, 431-437.
  39. Dansky, B. S., Roitzsch, J. C., Brady, K. T., Saladin, M. E. (1997) Posttraumatic stress disorder and substance abuse:  Use of research in a clinical setting. Journal of Traumatic Stress, 10, 141-148. 
  40. Dansky, B. S., Brady, K. T., Saladin, M. E., Killeen, T., Becker, S. & Roitzsch, J.  (1996) Victimization and PTSD in Individuals with Substance Use Disorders:  Gender and Racial Differences. American Journal of Drug and Alcohol Abuse, 22, 75-93.
  41. Saladin, M. E., Brady, K. T., Dansky, B. S. & Kilpatrick, D. G. (1995).  Understanding Comorbidity between PTSD and Substance Use Disorders: Two Preliminary Investigations. Addictive Behaviors, 20, 643-655.
  42. Dansky, B. S., Saladin, M. E., Brady, K. T., Kilpatrick, D. G. & Resnick, H. S. (1995) Prevalence of Victimization and PTSD among Women with Substance Use Disorders:  Comparison of Telephone and In-Person Assessment Samples. International Journal of the Addictions, 30, 1079-1099.
  43. Saladin, M. & Ness, D. (1995).  The therapist:  Some thoughts on living well. In D. G. Martin (Ed.). First steps in the art of intervention:  A guidebook.  Brooks/Cole Publishing Company.
  44. Brady, K. T., Killeen, T., Saladin, M. E., Dansky, B. S. & Becker, S. (1994).  Comorbid substance abuse and post-traumatic stress disorder:  Characteristics of women in treatment.  The American Journal on Addictions, 3, 160-164.
  45. Freedy, J. R., Saladin, M. E., Kilpatrick, D. G., Resnick, H. S. & Saunders, B. E. (1994). Understanding acute psychological distress following natural disaster. Journal of Traumatic Stress, 7, 257-273. S
  46. Saladin, M. E., Ten Have, W. N., Saper, Z. L., Labinsky, J. S. & Tait, R. W. (1989).  Retardation of rabbit nictitating membrane conditioning following US preexposures depends on the distribution and number of US presentations. Animal Learning and Behavior, 17 (2), 179-187.
  47. Saladin, M. E., Saper, Z. L. & Breen, L. J. (1988).  Perceived attractiveness and attributions of criminality:  What is beautiful is not criminal. Canadian Journal of Criminology, 30 (3), 251-259.
  48. Tait, R. W. & Saladin, M. E. (1986).  Concurrent development of excitatory and inhibitory associations during backward conditioning. Animal Learning and Behavior, 14 (2), 133-137.
  49. Saladin, M. E. & Tait, R. W. (1986).  US preexposures retard excitatory and facilitate inhibitory conditioning of the rabbit’s nictitating membrane response. Animal Learning and Behavior, 14 (2), 121-132.

Grants

  1. PI on RC1 titled “Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence”, NIAAA, Total Years 10/01/2009-09/31/2011, Total Budget = $800,000.
  2. Co-I on R21/R33 titled “The Impact of Real-Time fMRI Feedback on Response to Nicotine Cues”, NIDA, Total Years = 09/01/2008-08/31/2013, Total Budget = $2,152,944.
  3. Co-I on RO1 titled “D-Cycloserine Facilitation of Cocaine-Cue Extinction”, NIDA, Total Years = 07/01/2008-06/30/2012, Total Budget = $1,460,000.
  4. PI on R21 titled “Treatment Implications of Beta-blockade Effects on Memory for Cocaine Craving”, NIDA, Total Years = 09/01/2008-08/31/2010, Total Budget = $398,740.
  5. Co-PI on P50 component titled “Menstrual Cycle, Smoking Cue Reactivity and Smoking Cessation”.  National Institutes of Health, Office of Research on Women’s Health. (ORWH: Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women’s Health), Co-PI: Kevin Gray, M.D., Total Years = 2007-2012.  Total Direct Costs, $750,000.
  6. Co-I on R21 titled “Interaction of Stress and Cues in Marijuana Craving”, NIDA, Total Years = 9/1/2006-8/31/2008, Total Budget = $275,000.
  7. Co-I on RO1 titled “A Novel Treatment to Boost Quit Attempts and Cessation Among Unmotivated Smokers”, NIDA, Total Years = 7/1/2006-6/30/2010, Total Budget = $1,241,000.
  8. Mentor on K23 titled “Stimulus Control and Trajectories of Adolescent Smoking”, NIDA, Total Years = 9/1/2006-8/31/2011, Total Budget = $601,931.
  9. CI on P20 titled “Translational Research in Addiction Center” focused on methamphetamine addiction, NIDA, Total Years = 9/30/06-8/31/2010, Total Budget = $2,400,000.
  10. CI and MUSC PI on “Virtual Reality Cue Exposure for Crack Cocaine Dependence". Phase 1 STTR submitted to the National Institute on Drug Abuse (NIDA), Total Years = 07/01/03-06/30/04. Total Direct Costs, $134,489.
  11. CI on “Gender differences in response to cues in cocaine dependence”.  NIH, Office of Research on Women’s Health.  (ORWH: Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women’s Health), PI: Kathleen Brady, M.D., Ph.D., Total years = 2002-2007.  Total Direct Costs, $668,303.
  12. CI on “Gender, menstrual cycle, and smoking cue reactivity”.  National Institutes of Health, Office of Research on Women’s Health. (ORWH: Specialized Center of Research (SCOR) on Sex and Gender Factors Affecting Women’s Health), PI: Himanshu Upadhyaya, M.D., .
  13. Site PI and faculty expert for “Motivational Incentives for Enhanced Drug Abuse Recovery or MIEDAR”.  South Carolina Node of the NIDA Clinical Trials Network (CTN), NIH/NIDA grant # 1 U10 DA 13727-01, PI= Kathleen Brady, MD, Ph.D., Total years - 9/30/00-8/31/05, Total CTN Funding - $11,000,000.
  14. PI on Interim funding application entitled “Cue Reactivity in Comorbid PTSD and Drug Dependence”, Interim Funding Committee at the Medical University of South Carolina, Funding amount obtained-$50,000. Total years- 08/01/00-07/31/02.
  15. CI on NIH Competing Continuation of “Alcohol Research Center: Treatment and Implication- Component #3”, National Institute on Alcohol Abuse and Alcoholism (NIAAA), PI= Robert J. Malcolm, M.D., Funding amount -$760,909. Total years - 12/01/00-11/30/05.
  16. CI on NIH Competing Continuation of “Alcohol Research Center: Treatment and Implication- Component #5”, National Institute on Alcohol Abuse and Alcoholism (NIAAA), PI= Kathleen Brady, M.D., Ph.D., Total years- 12/01/00-11/30/05, Funding amount -$381,299.
  17. CI on grant “Impulsivity/Risk-Taking in a Cocaine Dependent Sample”, Medical University of South Carolina (MUSC) University Research Council, PI = Scott F. Coffey, Ph.D., Total years-4/1/99-3/31/00, Funding amount- $12,000.
  18. CI on grant titled “Biobehavioral Mechanisms in Genetic Risk for Smoking”, National Cancer Institute (NCI), PI= David J. Drobes, Ph.D., Total years- 04/01/99-03/31/01, Funding amount-$308,938.
  19. CI on grant titled “Cue Reactivity in Comorbid PTSD and Alcoholism”, Medical University of South Carolina (MUSC) University Research Council, PI= Bonnie S. Dansky, Ph.D., Total years- 5/1/96-4/30/97, Funding amount- $8,000.
  20. PI on grant titled “Cue Reactivity in Comorbid PTSD and Drug Dependence”, National Institute on Drug Abuse (NIDA), Total Years = 07/01/96-06/30/99, Funding amount -$647,680.
  21. PI on grant titled “A New Methodology for Measuring Alcohol Cue Reactivity”, Medical University of South Carolina (MUSC) University Research Council, Total years- 8/1/94-7/30/95, Funding amount- $16,994.
  22. CI on supplemental grant titled “Alcoholic Women with PTSD:  Naltrexone and CBT Treatment”, Funding Agency-National Institute for Alcohol Abuse and Alcoholism (NIAAA), PI- Raymond F. Anton, MD, Total years- 7/1/93-9/30/95, Funding amount- $99,849.
  23. Co-PI on supplemental grant titled “Victimization in Cocaine Dependent Women”, National Institute on Drug Abuse (NIDA), PI= Kathleen Brady, MD, Ph.D., Total years- 7/1/93-9/30/95, Funding amount- $99,703.

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