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Outcomes and Economics

Economic Modeling

Juvenile Idiopathic Arthritis Economic Model
Sponsor: Abbott Laboratories  |  PI: Kit Simpson
The goal is to use data from the pivotal clinical placebo controlled crossover trial and its follow up period, to construct a Markov model that captures the essentials of the effects of using Tumor Necrosis Factor inhibitor Humira with or without methotrexate on the quality of life and economics of children with Juvenile Idiopathic Arthritis

A Study of Antiretroviral Drugs in Pregnant Women in the U.S.
Sponsor: Abbott Laboratories  |  PI: Kit Simpson
This is a retroactive study to assess the use of antiretroviral drug treatment in pregnant women in the U.S. It will employ archival billing data from commercial insurers, hospital discharge data, and Medicaid data to examine important issues surrounding the use of Kaletra and other retroviral drugs in women of childbearing age, with a specific focus on child birth.

Critical Care Excellence in Sepsis and Trauma (CREST)
Sponsor: NIH/ National Center on Minority Health and Health Disparities  |  PI: Dee Ford; Co-I: Kit Simpson
The major objective is to improve outcomes for sepsis and trauma. The CREST program is novel and may represent an important solution to the emerging critical care crisis.

Assessment of Pediatric Look-Alike, Sound-Alike (LASA) Substitution Errors
Sponsor: Agency for Healthcare Research and Quality  |  PI: William Basco; Co-I: Kit Simpson
The goal is to expand on preliminary work completed as part of Dr. Basco’s K08 award to estimate frequencies of LASA errors in children and to identify candidate drugs for real time error screening.

Cost-Effectiveness and Cost-Benefit of Multi-Slice Coronary CT Angiography versus Cardiac Catheterization in Patients with Abnormal Myocardial Perfusion Studies
Sponsor: General Electric Healthcare/Siemans Medical Solutions  |  PI: Joseph Schoepf; Co-I: Kit Simpson
The goal is to compare CT angiography with the traditional gold standard of invasive coronary artery catheterization for cost-effectiveness, cost-benefit, sensitivity, and specificity for detection and grading coronary artery disease in patients already referred for cardiac catheterization because of abnormal nuclear myocardial perfusion imaging.


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