Raymond DuBois, MD, PhD, was named Dean of the College of Medicine at the Medical University of South Carolina in March 2016. For four years prior to coming to MUSC, Dr. DuBois was Executive Director of the Biodesign Institute at Arizona State University with a joint appointment as Professor of Medicine in the Mayo College of Medicine. From 2007 to 2012, he served as Provost and Executive Vice President and Professor of Cancer Medicine and Cancer Biology at The University of Texas MD Anderson Cancer Center in Houston. From 1998 to 2004, he directed Vanderbilt’s Division of Gastroenterology, Hepatology and Nutrition, and served as Director of the Vanderbilt-Ingram Cancer Center from 2005 to 2007.
Dr. DuBois is an internationally renowned expert for his studies on the molecular and genetic basis for colorectal cancer. His laboratory examines the molecular mechanisms by which inflammatory mediators affect epithelial biology, the tumor microenvironment, carcinogenesis and development. In the 1990s, DuBois and colleagues reported that colorectal tumors contained high levels of the enzyme cyclooxygenase-2 (COX-2). This enzyme is a key step in the production of pro-inflammatory mediators such as prostaglandin E2 (PGE2). This work led to a better understanding of the role of anti-inflammatory agents like aspirin in the tumor microenvironment, and subsequently resulted in various clinical trials, including treating precancerous polyps with Celebrex®, an arthritis drug that selectively inhibits COX-2. More recent studies have revealed that PGE2 regulates the immune status of the tumor microenvironment and inhibitors of PGE2 signaling block tumor metastasis.
Dr. DuBois a Fellow of the American Association for the Advancement of Science and AACR, Past President of the American Association for Cancer Research, the Southern Society for Clinical Investigation, and the International Society for Gastrointestinal Cancer. He is also a member of the American Clinical and Climatological Association, the Royal College of Physicians, the Association of American Physicians and the American Society for Clinical Investigation.
During his career as a physician-scientist, DuBois has published over 150 peer reviewed research articles, more than 60 article reviews, 25 book chapters, and three books. His work has been cited over 49,000 times according to Google Scholar. He is a co-inventor of a method to identify and prevent cellular genes needed for viral growth and cellular genes that function as tumor suppressors in mammals.
DuBois earned a bachelor’s degree from Texas A&M University and a doctoral degree from The University of Texas Southwestern Medical Center in Dallas. He obtained a medical degree from The University of Texas Health Science Center in San Antonio, followed by an Osler Medicine internship and residency, and a gastroenterology fellowship at the Johns Hopkins Hospital in Baltimore.