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    Ellipticine is an established anticancer chemotherapeutic, however, its current method of synthesis requires many steps. MUSC researchers have developed a method to obtain ellipticine analogs in one step by utilizing radiation and an acid catalysis. The ellipticine family represents a class of natural products that have been used to develop potential treatments for cancer, HIV, and malarial infection. Recent communications have described rapid access approaches toward quninone4 and aza5 analogs from a common indoline core.
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    The invention provides for a novel approach of treating lung fibrosis related diseases (including scleroderma lung disease, idiopathic pulmonary fibrosis, interstitial pneumonia, asbestosis). Currently, there are no effective treatments available for these diseases.  Upregulation of caveolin-1 was achieved by either infecting cells with adenovirus encoding the full-length caveolin-1 molecule or using a membrane-permeable peptide containing the caveolin-1 scaffolding domain (CSD).  Control bleomycin-treated mice showed severe lung damage, whereas mice receiving CSD showed only slight ...
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    Commercially available devices for vagus nerve stimulation are implantable devices, requiring an invasive and expensive procedure. MUSC researchers are developing a noninvasive device that stimulates the vagus system incorporating ear electrodes with optimized pulses that can be tailored based on the condition to be treated (epilepsy, depression, stroke, tinnitus, etc.). This device is currently undergoing testing at MUSC (n=15) in order to show direct brain effects as investigated by functional magnetic resonance imaging.
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    Inventors at MUSC have developed a high-quality, packaged, e-learning module for goniometry applicable to physical and occupational therapy that incorporates multi-media (audio & video), interactive text, goal setting, and documentation. The modules cover goniometry for upper extremities and lower extremities including elbow, hand, scapula, shoulder, thumb, and wrist. Each extremity is further divided into specific flexions, such as adduction, abduction, and internal and external rotation, for which content is presented.
  • SCTR / FRD Technology Development Grant Awards Two Investigators

    The South Carolina Clinical & Translational Research Institute (SCTR) and the MUSC Foundation for Research Development (FRD) are pleased to announce Nancy DeMore and Jennifer Wu as recipients of SCTR/FRD Technology Development Grant awards. Through this mechanism, SCTR’s Therapeutics Translation Core (TTC), in conjunction with the MUSC FRD, provides funding of up to $25,000 to advance innovative, clinically relevant technologies into marketed products.

    “With a much broader mission beyond intellectual property, FRD is proud to be a contributor to this granting effort since funding technology translation is a critical component to MUSC’s research and innovation strategy,” said Michael Rusnak, the Executive Director of MUSC’s Foundation for Research Development.

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  • Biomedical researcher Craig Beeson named as FRD 2015 Inventor of Year
     
    CHARLESTON, S.C. – Medical University of South Carolina (MUSC) Professor Craig Beeson, Ph.D., has earned 2015 Inventor of the Year honors from MUSC Foundation for Research Development for his leadership in creating molecular technologies for medical purposes, including eye drops to halt retinal degeneration that can lead to blindness.

    “Dr. Beeson’s phenomenal discoveries promise real-world applications not only in the realm of eye disease and disorders but on several other intriguing fronts as well,” said FRD Executive Director Michael Rusnak.
     
  • SC Medical Translational Technology Program - Submit Requests!

    The South Carolina Medical Translational Technology Program (SC MedTransTech) is soliciting proposals for grants to support education and outreach activities.

    The objective is to facilitate education and outreach on biomedical research advances, needs and opportunities, outcomes, diagnostics, and therapeutics to the healthcare community including faculty, staff, clinicians, and patients at MedTransTech participating organizations.The scope of activities encompassed by this program includes
    (l) hosting of courses, retreats, seminars, and workshops (i.e., events aimed at training and communicating information) and
    (2) travel to courses or conferences that offer specialized education or outreach opportunities that can be implemented upon return. 

    *Months of September & October - Open enrollment and deadline for grant proposals

    For questions regarding the MedTransTech Program, contact: Jesse Goodwin (goodwijs@musc.edu)
    For questions pertaining to submission of a proposal, contact: Michael Gara (mjgara@clemson.edu)

     
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