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  • Electrobiome: Microbial Production of Chemicals & Fuels from Carbon Dioxide

    The inventors have developed an electrosynthetic microbiome, called the ElectrobiomeTM, that directly converts CO2, water, and small amounts of electricity into hydrogen (H2), formic acid, and acetic acid.  MUSC researchers have identified alternative conditions capable of driving the Electrobiome towards higher yields of acetic acid or hydrogen.  The outputs from the Electrobiome can then be fed into a second bioreactor to generate bioplastics.  The Electrobiome has been continually operating for more than three years, which demonstrates sustainability that far surpasses other electrosynthetic microbiomes.  As an added benefit, the electrical input into the Electrobiome can be intermittent, allowing it to run only when low-cost electricity is available.  Thus far, >1kg of H2 or acetic acid per m3 of reactor volume may be produced per day (1kg H2 ? 1 gallon gasoline equivalent) without costly, rare-earth catalysts at the cathode. 

  • Peptide for Wound Healing and Tissue Repair
    The inventors have developed a wound-treating material for use in promoting wound healing, decreasing scarring, decreasing inflammation, or promoting formation of healthy tissue architecture post-injury. This JM2 peptide effectively works by blocking hemichannels and lessening ATP release from cells. The JM2 peptide is able to modulate the initial innate immune response to rebuild normal tissue instead of scar tissue. When utilizing the JM2 peptide, there is improved vasculature surrounding an implant capsule with a smaller connective tissue response. This technology has applications in not only surgical implants and dermatological applications, but also age-related macular degeneration and many other injuries or inflammation that are a result from trauma, surgery, or disease.

  • Researchers at MUSC have developed a high-throughput assay that uses fluorescence polarization (FP) to distinguish the fluorescent penicillin, Bocillin-FL, in free or PBP-bound form.  The assay can be used to identify new compounds that inhibit penicillin binding proteins (PBPs), which are proven targets for ?-lactam antibiotics. This assay was used to screen a 50,000 compound library for potential inhibitors of N. gonorrhoeae PBP 2. As a result, 32 compounds were identified that exhibited >50% inhibition of Bocillin-FL binding to PBP 2. These included a cephalosporin that provided validation of the assay. This assay paves the way for more comprehensive high-throughput screening of compound libraries for non-?-lactam antimicrobial compounds.
    Researchers at MUSC have identified a specific fragment of the mesenchymal-epithelial transition factor (MET) receptor as a peptide with robust antifibrotic properties. Preliminary studies show that the purified peptide markedly reduces collagen and other extracellular matrix proteins in scleroderma lung fibroblasts and in TGF-?-stimulated normal lung fibroblasts.
  • SCBIO Life Science Startup Workshop
  • BIG Series Event
    FRD announces product launch of technology from MUSC Healthcare Simulation Center to improve training for labor and delivery
    Promising technology born at the Medical University of South Carolina Healthcare Simulation Center is now available as an improvement to Laerdal Medical’s SimMom, a manikin that simulates childbirth for medical training. The MUSC Foundation for Research Development filed the patent application for the adaptation and exclusively licensed it for commercial purposes to Laerdal, which recently made the new module available to the public.
    “Simulation offers an effective way to train medical students and other health care professionals for real-life situations, ultimately producing better patient outcomes,” said FRD Executive Director Michael Rusnak. “This enhancement of SimMom’s capabilities will improve obstetrics training worldwide and is yet another accomplishment for MUSC’s Healthcare Simulation Center, which has quickly emerged as a leader in the evolving field of medical simulation.” 
    The Medical University of South Carolina Foundation for Research Development (FRD) has announced that venture capitalist Art Pappas has joined the organization’s Board of Directors, effective immediately.
    Pappas is a managing partner at Pappas Ventures, which is based in Durham, N.C., and invests exclusively in the life sciences sector, specifically biotechnology, specialty pharmaceuticals, drug delivery, diagnostics, medical devices and related ventures...
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