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    Ellipticine is an established anticancer chemotherapeutic, however, its current method of synthesis requires many steps. MUSC researchers have developed a method to obtain ellipticine analogs in one step by utilizing radiation and an acid catalysis. The ellipticine family represents a class of natural products that have been used to develop potential treatments for cancer, HIV, and malarial infection. Recent communications have described rapid access approaches toward quninone4 and aza5 analogs from a common indoline core.
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    The invention provides for a novel approach of treating lung fibrosis related diseases (including scleroderma lung disease, idiopathic pulmonary fibrosis, interstitial pneumonia, asbestosis). Currently, there are no effective treatments available for these diseases.  Upregulation of caveolin-1 was achieved by either infecting cells with adenovirus encoding the full-length caveolin-1 molecule or using a membrane-permeable peptide containing the caveolin-1 scaffolding domain (CSD).  Control bleomycin-treated mice showed severe lung damage, whereas mice receiving CSD showed only slight ...
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    Commercially available devices for vagus nerve stimulation are implantable devices, requiring an invasive and expensive procedure. MUSC researchers are developing a noninvasive device that stimulates the vagus system incorporating ear electrodes with optimized pulses that can be tailored based on the condition to be treated (epilepsy, depression, stroke, tinnitus, etc.). This device is currently undergoing testing at MUSC (n=15) in order to show direct brain effects as investigated by functional magnetic resonance imaging.
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    Inventors at MUSC have developed a high-quality, packaged, e-learning module for goniometry applicable to physical and occupational therapy that incorporates multi-media (audio & video), interactive text, goal setting, and documentation. The modules cover goniometry for upper extremities and lower extremities including elbow, hand, scapula, shoulder, thumb, and wrist. Each extremity is further divided into specific flexions, such as adduction, abduction, and internal and external rotation, for which content is presented.
  • SCTR Technology Development Grant Awardees
    Congratulations to Nathan Dolloff, Ph.D. and James Chou, Ph.D. on receiving the most recent SCTR technology development grants.

    James Chou, Ph.D.'s research focus is centered around the neuro-vitamin K (VK) synthase UBIAD1, which has recently been identified through a forward genetic screen as a dominant enhancer of the Parkinson’s disease (PD) establishing an additional link among mitochondria, vitamin K, and PD pathogenesis. Supplementation of VK reverses the non-flight phenotype observed in the drosophila model.  Unfortunately, for humans, neuronal VK requires a series of metabolic processes and direct synthesis by UBIAD1 in the central nervous system in situ, and cannot be supplemented through dietary means.  We have developed VK analogs that can easily penetrate blood-brain barrier and showed effective in the chemical induced PD model.  The SCTR-FRD Grant will allow the optimization of the lead drug candidate’s dosing routine instead of performing the costly efficacy experiments blindly.  With the funded study, it will also significantly move the project forward for future efficacy studies.

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  • MUSC Start-Up Wins Prestigious National Award
    Congratulations to ToleRaM Nanotech, LLC  for winning a National TechConnect Innovation Award, which is meant to recognize innovative technology that has the potential to make a difference in a special sector, such as medicine. Only 15% of submitted entries receive the prestigious award.
     
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  • STTR Notice of Awards
    Congratulations to MUSC startup company, CuRE Innovations, on receiving national STTR grant funding to help advance their technology.

    CuRE Innovations (www.cure-innovations.com) is a dental materials company dedicated to improving oral health through the development of innovative materials that address the deleterious impact of microbes and enzymatic degradation in the oral environment. CuRE’s funding will be used to evaluate the ability of the copper iodide dental adhesive to inhibit development of marginal decay in restorations, and ensure that the copper iodide particles do not impact the mechanical and bonding properties of the adhesive.
  • Successful Startup Event Held at MUSC
    On Friday, March 4th, the College of Medicine Center for the Advancement, Recruitment, and Retention of Women in Science (ARROWS), the MUSC Foundation for Research Development (FRD), and the South Carolina Medical Translational Technology Program (SC MedTransTech) hosted a workshop on What Every Entrepreneur Needs to Know: Establishing a Startup in the Life Sciences. With about 40 attendees, the workshop began with a “nuts & bolts” guide to starting a company featuring local attorneys Jamison Cox, JD and Micah S. Johnson, with Smith Cox and Associates, and James Streetman, CPA and founding partner of Streetman, Jones & Powers, LLC. They spoke on the differences in forming a corporation versus a limited liability company and the ownership and management choices that go along with each. They also spoke on documentation processes, working with multiple owners and hiring practices.
     
    The keynote speaker for this event was Amy Salzhauer. She is a managing partner at Good Growth Capital, a new investment firm designed to find and fund amazing innovations and entrepreneurs in under-funded markets. Amy’s light-hearted approach and enthusiasm made this topic seem less overwhelming. She spoke on the basics of founding a startup in the life sciences, how to present effectively to potential investors, specific tools to understand risk, financial models and strategies, and negotiating terms with investors. Look to the future to see some amazing scientific innovations come out of budding and current entrepreneurs that attended this event!
     
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