| Michael Zile, M.D.
Research Interests include: 1) Identifying the basic myocardial, cellular, extracellular, and molecular mechanisms causing diastolic heart failure, 2) developing new treatment strategies to treat diastolic heart failure, 3) defining the transsarcolemmal and intracellular signal transduction mechanisms which modulate myocardial, extracellular matrix and cardiomyocyte growth. His laboratory is supported by grants from the National Heart, Lung and Blood Institute, the American Heart Association, the Department of Veterans Affairs and the Medical University of South Carolina.
 Laboratory Members Catalin Baicu, Ph.D. Tim Brooks Elizabeth Hapke Weems Pennington, Ph.D. Fei Qiao, M.D. An Van Laer
| Publications Pubmed Listings Tanaka R, Barnes MA, Cooper G,IV, Zile MR: Effects of anisosmotic stress on adult mammalian cardiac muscle length, diameter, area, and sarcomere length. Am J Physiol, 270 :H1414-H1422, 1996. Wada H, Zile MR, Ivester CT, Cooper G, IV, McDermott PJ: Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture. Am J Physiol, 271: H29 - H37, 1996. Kato S, Koide M, Cooper G, IV, Zile MR: Effects of pressure or volume overload hypertrophy on passive stiffness in isolated adult mammalian cardiac muscle cells. Am J Physiol, 271: H2575 - H2583, 1996. Tagawa H, Wang N, Narishige T, Ingber DE, Zile MR, Cooper G, IV: Cytoskeletal mechanics in pressure overload cardiac hypertrophy. Circ Res, 80:281 - 289, 1997. Koide M, Nagatsu M, Zile MR, Hamawaki M, Swindle M, Keech G, DeFreyte G, Tagawa H, Cooper G, IV, Carabello B: Premorbid determinants of left ventricular dysfunction in a novel model of gradually induced pressure overload in the adult canine. Circulation, 95:1601-1610, 1997. Gramling-Babb P, Miller MJ, Reeves ST, Roy RC, Zile MR: Treatment of medically and surgically refractory angina pectoris with high thoracic epidural analgesia: Initial clinical experience. Am Heart Journal, 134:648-55, 1997. Tagawa H, Koide M, Sato H, Zile MR, Carabello BA, Cooper G IV: Cytoskeletal role in the transition from compensated to decompensated hypertrophy after adult canine left ventricular pressure overloading. Circ Res, 82:751-761, 1998. Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ: Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol, 275: H65 - H74, 1998. |
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| Michael Zile, M.D. Principal Investigator at the Gazes Cardiac Research Institute Professor of Medicine Director of the Medical Intensive Care Unit at the Ralph H. Johnson Department of Veterans Affairs Medical Center
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| Dr. Zile's Contact Information | | Department of Medicine Division of Cardiology CSB 816, PO Box 250623 Charleston, SC 29425
Phone: (843)792-4457 Fax: (843)792-7771 Email: zilem@musc.edu
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| | Knox College, B.S.
| | Rush University, M.D. | | Residency in Internal Medicine, Rush Presbyterian-St. Lukes Medical College, Chicago, IL | Cardiology Fellow, Tufts-New England Medical Center, Boston, MA
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