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Gazes Cardiac Research Institute

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 Gazes Cardiac Research Institute | faculty | Terrence X. O'Brien, M.D., F.A.C.C.

Terrence X. O'Brien, M.D., F.A.C.C.

Our laboratory has several specific interests, revolving around applying the tools of molecular biology to the study transcriptional regulation in cellular and animal models of cardiac hypertrophy and failure. Specific projects include examining the cardiac regulation of 2 oxidative phosphorylation genes whose products increase when cardiac myocytes hypertrophy. Techniques include cell line and cardiac myocyte culture, transient transfection, models of hypertrophic stimulation as well as mouse aortic banded and pulmonary artery banded cat models. Additional effort is being put in an effort to use adenoviral vectors to allow transient transfection into adult cardiac myocytes. Cardiac-specific tanscriptional regulation is being examined by over-expressing the cardiac-specific homeobox factor Nkx2-5 and the more ubiquitous serum response transcription factor (SRF), with which Nkx2-5 associates. The expression of selected gene products that upregulate during cardiac hypertrophy are then examined. Molecular markers of abnormal cardiac hypertrophy as well as changes in protein synthesis and cellular morphogenesis are examed as end-points.

Dr O'Brien's Lab
Laboratory Members
Brett Harris, Ph.D.
Mary Rackley


Pubmed Listings

1.     Thompson JT, Rackley MS, and O’Brien TX.  Up-regulation of the cardiac homeobox gene Nkx2.5 (CSX) in feline right ventricular pressure overload.  Am. J. Physiol. 274 (Heart Circ. Physiol. 43) H1569-H1573, 1998.

2.     O’Brien TX, Thompson JT, Schuyler GT, Rackley MS, and Cooper G IV. F1ATPase synthase b-subunit and cytochrome c transcriptional regulation in right ventricular hemodynamic overload and hypertrophically stimulated cardiomyocytes.  J. Mol. Cell Cardiol. 31, 167-178, 1999.

3.Muller JG, Thompson JT, Rackley MS, McQuinn TC, Menick DR, O’Brien TX.  Co-regulation of Nkx2-5 and serum response factor induced activation of the cardiac sodium-calcium exchanger promoter.  Journal of Molecular and Cellular Cardiology, 34:807-821, 2002.

4. Gourdie RG, Harris BS, Bond J, Justus C, Hewett K, O’Brien TX, Thompson RP, Sedmera D.  Development of the cardiac pacemaking and conduction system.  Birth Defects Research, 69:46-57, 2003.

6.     Bastarrika G, Brabham WW, O'Brien TX, Costello P, Schoepf UJ. Dual-source computed tomography assessment of malfunctioning mechanical prosthetic valve. Ann Thorac Surg. 2009;87(5):e50.

8. O’Brien TX. Iron Metabolism, Anemia and Heart Failure. J Am Coll Card ed, 13;58(12):1252-3, 2011

9. Renker M, Nance JW, Schoepf UJ, O’Brien TX, Zwerner PL, Meyer M, Kerl JM, Bauer RW, Fink C, Vogl TJ, Henzler T. Evaluation of heavily heavily calcified vessels with coronary CT angiography: comparison of iterative and filtered back projection image reconstruction. Radiology, 260(2):390-9, 2011.

10. Udelson JE, Bilsker M, Hauptman PJ, Sequerira R, Thomas I, O’Brien TX,  Zimmer C, Konstam MA.  A multicenter, randomized, double-blind, placebo-controlled study of tolvaptan monotherapy compared to furosemide in patients with heart failure and systolic dysfunction. J Card Fail. 2011 Dec;17(12):973-81

Terrence X. O'Brien, M.D., F.A.C.C.

Terrence X. O'Brien, M.D., F.A.C.C.
Principal Investigator at the Gazes Cardiac Research Institute
Associate Professor of Medicine, Anatomy and Cell Biology

Dr. Obrien's Contact Information

Department of Medicine, Division of Cardiology, MUSC
96 Jonathan Lucas St.
816 CSB, P.O. Box 250623
Charleston, SC 29425

Phone: (843)792-6622
Lab   :  (843)876-5072
Fax: (843)792-7771
Page: (843)792-2123
Dr. Obrien's Education
1980 B.S. Chemistry, Stanford University, (Co-Awarded w/M.S. Degree)
1980 M.S. w/Honors Biological Sciences, Stanford University
1984 M.D. University of California, San Diego
1987 Residency in Internal Medicine, Univerisity of Texas Southwestern Medical Center, Dallas, TX; Parkland Memorial Hospital and VAMC, Dallas, TX
1990 Cardiology Fellow; University of California Medical Center and VAMC, San Diego, CA
1993 Research Postdoctoral Fellowship in Molecular Cardiology; Bugher Foundation-American Heart Association; Dept. of Medicine and Center for Molecular Genetics; University of California, San Diego, CA
Specialty/Board Certifications
1987 Diplomate, American Board of Internal Medicine
1991 Diplomate, American Board of Cardiovascular Diseases