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Gazes Cardiac Research Institute

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 Gazes Cardiac Research Institute | faculty | Michael Zile, M.D.

Michael Zile, M.D.

Research Interests include:

1) Identifying the basic myocardial, cellular, extracellular, and molecular mechanisms causing diastolic heart failure, 2) developing new treatment strategies to treat diastolic heart failure, 3) defining the transsarcolemmal and intracellular signal transduction mechanisms which modulate myocardial, extracellular matrix and cardiomyocyte growth. His laboratory is supported by grants from the National Heart, Lung and Blood Institute, the American Heart Association, the Department of Veterans Affairs and the Medical University of South Carolina.

Dr Zile's Lab
Laboratory Members
Catalin Baicu, Ph.D.
An Van Laer,MS


Pubmed Listings

Matsuo T, Carabello BA, Nagatomo Y, Koide M, Hamawaki M, Zile MR, McDermott PJ: Mechanisms of cardiac hypertrophy in canine volume overload. Am J Physiol, 275: H65 - H74, 1998.

  Zile MR, Baicu CF, Stroud RE, Van Laer A, Arroyo J, Mukherjee R, Jones JR, Spinale FG. Pressure-Overload Department Membrane-Type 1 Matrix Metalloproteinase Induction: Relationship to LV Remodeling and Fibrosis. Am J Physiol Heart Circ Physiol. 302: H1429-37, 2012. PMCID: PMC3330784 [Available on 2013/4/1]

 Yarbrough WM, Mukherjee R, Stroud RE, Rivers WT, Oelsen JM, Dixon JA, Eckhouse SR, Ikonomidis JS, Zile MR, Spinale FG. Progressive Induction of Left Ventricular Pressure Overload in a Large Animal Model Elicits Myocardial Remodeling and a Unique Matrix Signature. class="jrnl"J Thorac Cardiovasc Surg. 143:215-23, Jan 2012. PMCID: PMC3241904 [Available on 2013/1/1]

 Zile MR, Mehurg SM, Arroyo JE, Stroud RE, DeSantis SM, Spinale FG. Relationship Between The Temporal Profile of Plasma microRNA and Left Ventricular Remodeling In Patients Following Myocardial Infarction. Circulation: Cardiovascular Genetics. 4:614-9, 2011. PMCID: In Progress.

Zile MR, Gottdiener JS, Hetzel SJ, McMurray JJ, Komajda M, McKelvie R, Baicu CF, Massie BM, Carson PE. Prevalence and Significance of Alterations in Cardiac Structure and Function in Patients with Heart Failure and a Preserved Ejection Fraction. Circulation. 124:2491-2501, 2011.  PMID 22064591

 Desai RV, Ahmed MI, Mujib M, Aban IB, Zile MR, Ahmed A. Natural History of Concentric Left Ventricular Geometry in Community-Dwelling Older Adults without Heart Failure During Seven Years of Follow-up. Am J Cardiol, 107: 321-4, 2011. PMCID: PMC3022324

 Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Bonnema DD, Zile MR. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. Am J. Physiol Heart Circ Physiol. 298:H614-22, 2010. PMCID: PMC2822576.

Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Boggs J, Lacy JM, Zile MR. Pressure-Overload Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function:  Role of SPARC in Post-Synthetic Procollagen Processing.  Circulation, 119(2):269-280, 2009. PMCID:  PMC2734276.

Michael Zile, M.D.

Michael Zile, M.D.
Principal Investigator at the Gazes Cardiac Research Institute
Professor of Medicine
Director of the Medical Intensive Care Unit at the Ralph H. Johnson Department of Veterans Affairs Medical Center

Dr. Zile's Contact Information

Department of Medicine
Division of Cardiology
CSB 816, PO Box 250623
Charleston, SC 29425

Phone: (843)792-4457
Fax: (843)792-7771
Dr. Zile's Education
Knox College, B.S.
Rush University, M.D.
Residency in Internal Medicine, Rush Presbyterian-St. Lukes Medical College, Chicago, IL
Cardiology Fellow, Tufts-New England Medical Center, Boston, MA