College of Graduate Studies
Cancer Biology Course Descriptions
MCBP-725D/PCOL 747 Topics in Cancer Research
Two presentation formats will be used for the course. Initially, a faculty member will introduce and direct all students in the discussion of selected literature concerning a single topic. Subsequent topics will be presented by individual students in Journal Club style. Each student will have two opportunities to present selected topics during the course and will be active discussants when other students present. Topics to be covered include: Cell Proliferation and Cycle Control Apoptosis Oncogenes and Tumor Suppressor Genes Metastasis Angiogenesis Tumor Invasion Cell Adhesion Cell Migration Signal Transduction and Growth Regulation Molecular Profiling Translation Applications Transgenic and Knockout Models. Offered in Fall Semester of alternate years.
Credits: 3 (Pass/Fail)
Steve Rosenzweig, Ph.D., and Dennis Watson, Ph.D.
MCBP 748/BMB 748 Lipids in Pathobiology
This multidisciplinary course addresses biochemical, applied, and translational approaches to the study of lipids. The course is composed of three main sections: lipid biosynthesis, lipid signaling, and lipids and disease. The first section is a comprehensive treatment of nomenclature and synthesis of major lipid classes including glycerophospholipids, sphingolipids, and sterols, as well as methodology for lipid study. The second section addresses roles of bioactive members of these lipid classes in regulation of cell signaling and downstream events. The third section is largely translational, with many lectures on human diseases that involve the lipids and signaling pathways discussed. This course contains a brief hands-on laboratory segment. This course is open this to graduate students, residents, postdocs, and third and fourth medical students.
Director: Samar M. Hammad (Co-Director: Ashley Cowart)
Offered every two years in the Spring
MCBP 753 Cell Biology and Cancer Journal Club
This is a journal club counting for 1 credit hour which will meet 2X per month during the fall and spring semesters. Each student will be required to lead a discussion (approximately 2 hours) on at least one article which has been recently published on a broad range of topics including basic cellular mechanisms, cancer biology and disease. All students will be encouraged to ask questions and participate in discussions. Student presentations will be augmented by the addition of interested postdoctoral fellows and faculty.
Course Directors: Dr. R. Muise-Helmericks and Dr. Alan Diehl
BMB-605B Mechanisms of Cancer Pathogenesis
The abnormal behavior of neoplastic cells can often be traced to alterations in cell death and apoptosis. Lipids, in particular sphingolipids such as ceramide, represent the major regulatory mechanism of the apoptotic process. This course will provide the study of lipid metabolism and lipid cell signaling mechanisms involved in the transformation process, the study of altered levels of specific growth factors, intracellular processes for conveying lipid membrane signals to the nucleus, portions of the transcription apparatus, and genes involved in the cell cycle and the regulation of DNA replication. Offered in Fall Semester of alternate years.
Director: Tilman Heise, Ph.D.
MBIM-786 Cancer Immunotherapy Lessons
This course will combine didactic lectures with participation in mock study sections. The first 3 weeks of class will be lecture and the remaining 12 weeks will be used to review and critique past grant proposals related to cancer immunotherapy recently submitted by principal investigators at MUSC. Students will also attend the monthly meetings of the Cancer Immunology and Immunotherapy (CII) program faculty (4 meetings during the semester) and submit a 1 page written summary and response for each.
Course Directors: Zihai Li, Ph.D., Jennifer Wu, Ph.D., Chrystal Paulos, Ph.D., Mark Rubenstein, Ph.D., Beichu Guo, Ph.D., Christina V. Johnson, Ph.D., Chenthamaraksha Vasu, Ph.D.
PATH-792 Anatomy, Histology and Histopathology of the Laboratory Mouse
This course is offered as an elective course during the first three weeks of the summer semester. The anatomy, histology, and histopathology of the laboratory mouse will be presented. Emphasis will be placed on differences between human and mouse so future investigators who may use a mouse model of human disease will understand approaches to developing new modes as well as limitations of a given model. Lectures will present anatomy, histology, basic principles of pathobiology and unique mouse pathology. Lab sessions will be used to demonstrate the proper way to perform a pathological examination on properly euthanized animals. Tutorials using glass and virtual slides will be included. Students will learn and execute a necropsy (term for post-mortem examination in veterinary medicine) of the mouse. Two Genetically Engineered Mouse (GEM) models will be introduced by Drs. Awgulewitsch and Spyropoulos at the end of the course to reinforce the significance of understanding differences between mouse and human anatomy, histology, and pathology. Due to the brevity of the course, only a limited number of pathological entities will be included. 3 credit hours. Prerequisite: PATH 789, Graduate Histology: Introduction to Pathology, or CELL 609: Medical Histology, or by permission of the course directors.
Elizabeth Garrett-Mayer, Ph.D., Kristi Helke, D.V.M., Ph.D., Demetri Spyropoulos, Ph.D., Alexander Awgulewitsch, Ph.D.
PCOL-744 Advanced topics in Cell Signaling
The vast majority of human diseases involve defects in cellular communication and therapeutic intervention often targets molecules involved in cell signaling. This course will dissect signaling cascades and their alterations in disease states addressing cutting edge issues. The course will be offered each Fall with the theme rotating among three broad topics: Cell Signaling in the Cardiovascular System, Cell Signaling in Cancer, Cell Signaling in the Nervous System. Specific diseases under these broader categories will be selected by faculty or students and then each disease will be dissected by one of the course participants (oral/written) to understand how signaling events are affected, how signaling dysfunction contributes to the onset or progression of the disease and how signaling events might be targeted in a therapeutic attack on the disease. The course is intended for advanced graduate and postgraduate students and will be coordinated with the Cell-Signaling Seminar Series (organized through the Department of Pharmacology) held each Fall, thus allowing seminar speakers to participate in the course.
Prerequisites: None. Offered in Fall and Spring semesters
Course Directors: Joe B. Blumer, Ph.D., (Co-director: Jennifer S. Isaacs, Ph.D.)
Cancer Biology Faculty
Alexander Awgulewitsch, Ph.D.
Craig Beeson, Ph.D.
Narayan R. Bhat, Ph.D.
Galina Bogatkevich, M.D., Ph.D.
Stephen Ethier, Ph.D.
Sebastiano Gattoni-Celli, M.D.
Robert M. Gemmill, Ph.D.
Stanley R. Hoffman, Ph.D.
Philip H. Howe, Ph.D.
Michael Kern, Ph.D.
Keith Kirkwood, Ph.D.
Dhandapani Kuppuswamy, Ph.D.
Anna-Liisa Nieminen, Ph.D.
James S. Norris, Ph.D.
Chandrakala Puligilla, Ph.D.
Mark Rubinstein, Ph.D.
Stephen Tomlinson, Ph.D.
Paula Traktman, Ph.D.
Christina Voelkel-Johnson, Ph.D.
Dennis K. Watson, Ph.D.
Elizabeth Yeh, Ph.D.
M. Rita I. Young, Ph.D.