College of Graduate Studies
Molecular Cell Regulation
Robin Muise-Helmericks, Ph.D. - Division Director
Molecular Cell regulation encompasses all the functions cells carry out to maintain homeostasis, in particular their responses to extracellular signals (hormones, neurotransmitters, etc.) and how they produce an intracellular response. In addition to these endogenous agents, many drugs and environmental agents use these same mechanisms to produce their most important effects. Numerous research opportunities exist within this program ranging from studies exploring new cell signaling mechanisms, to those examining basic the aberrant signaling mechanisms associated with disease states. Significantly, many of the recent breakthroughs in drug development stem from basic studies on signaling molecules.
The Molecular Cell Regulation program is comprised of over 30 faculty members whose research interests and expertise is related to cell regulation. In addition to a track-specific Molecular Cell Regulation Journal Club, advanced courses in Cell Signaling are available to students who select this track as their major emphasis.
Molecular Cell Regulation Course Descriptions
MCBP-725D/PCOL 747 Topics in Cancer Research
Two presentation formats will be used for the course. Initially, a faculty member will introduce and direct all students in the discussion of selected literature concerning a single topic. Subsequent topics will be presented by individual students in Journal Club style. Each student will have two opportunities to present selected topics during the course and will be active discussants when other students present. Topics to be covered include: Cell Proliferation and Cycle Control Apoptosis Oncogenes and Tumor Suppressor Genes Metastasis Angiogenesis Tumor Invasion Cell Adhesion Cell Migration Signal Transduction and Growth Regulation Molecular Profiling Translation Applications Transgenic and Knockout Models. Offered in Fall Semester of alternate years.
Credits: 3 (Pass/Fail)
Steve Rosenzweig, Ph.D., and Dennis Watson, Ph.D.
MCBP 743 - Cellular Signaling During Development
This course is designed to build on the Regulation of Gene Expression, Biomembranes, Receptors and Signaling and Systems Biology units of the first year curriculum for Ph.D. and complement ongoing Department-specific seminars and journal clubs. Cellular Signaling during development will provide the students with an indepth look at ongoing research in the field of developmental biology with a strong focus on the signaling networks that control these important processes. It will allow for a broad scope of understanding of the techniques, theories and practices involved in the delineation of cellular signaling in complex systems. Offered every Spring Semester.
Director: Robin C. Muise-Helmericks, Ph.D.
MCBP 748/BMB 748 Lipids in Pathobiology
This multidisciplinary course addresses biochemical, applied, and translational approaches to the study of lipids. The course is composed of three main sections: lipid biosynthesis, lipid signaling, and lipids and disease. The first section is a comprehensive treatment of nomenclature and synthesis of major lipid classes including glycerophospholipids, sphingolipids, and sterols, as well as methodology for lipid study. The second section addresses roles of bioactive members of these lipid classes in regulation of cell signaling and downstream events. The third section is largely translational, with many lectures on human diseases that involve the lipids and signaling pathways discussed. This course contains a brief hands-on laboratory segment. This course is open this to graduate students, residents, postdocs, and third and fourth medical students.
Director: Samar M. Hammad (Co-Director: Ashley Cowart)
Offered every two years in the Spring
MCBP 753 - Cell Biology and Cancer Journal Club
This is a journal club counting for 1 credit hour which will meet 2X per month during the fall and spring semesters. Each student will be required to lead a discussion (approximately 2 hours) on at least one article which has been recently published on a broad range of topics including basic cellular mechanisms, cancer biology and disease. All students will be encouraged to ask questions and participate in discussions. Student presentations will be augmented by the addition of interested postdoctoral fellows and faculty.
Course Directors: Dr. R. Muise-Helmericks and Dr. Alan Diehl
MCBP 762 - Mechanisms of Development
This course will provide a general overview of fundamental developmental mechanisms focused on a comparison of different model organisms. This 7 week long course covers early and intermediate developmental events (gastrulation and cardiovascular), stem cell biology, mouse molecular genetics and gene regulation, perinatal maturation through induction of stemness in differentiated adult cells and regenerative medicine. Comparative systems discussed include Drosophila, zebrafish, Xenopus, chick, mouse models and humans. The course is intended for graduate student training in any aspect of biomedical research. Offered in every Spring Semester (Spring Selectives).
Course Director: Yukiko Sugi, Ph.D.
MCBP 779 - Immunogenetics
Initial lectures will review the fundamental principles of genetics. The principle focus of the course will be the genetics of human MHC and immunoglobulin allotypes. Major blood genes will also be discussed. Statistical methods employed in delineating the genetic contribution to human diseases will be reviewed.
Course Director: Janardan Pandey, Ph.D.
Zsolt Ablonczy, Ph.D.
Alexander Awgulewitsch, Ph.D.
John E. Baatz, Ph.D.
Craig Beeson, Ph.D.
Narayan R. Bhat, Ph.D.
Galina Bogatkevich, M.D., Ph.D.
Amy Bradshaw, Ph.D.
Lee Chao, Ph.D.
Stephen A. Duncan, Dphil
Carol Feghali-Bostwick, Ph.D.
Gary Gilkeson, M.D.
Monika Gooz, M.D., Ph.D.
Philip Howe, Ph.D.
Jennifer Isaacs, Ph.D.
Christine B. Kern, Ph.D.
Michael Kern, Ph.D.
Masahiro Kono, Ph.D.
Dhandapani Kuppuswamy, Ph.D.
Roger R. Markwald, Ph.D.
Russell A. Norris, Ph.D.
Janardan P. Pandey, B.S., M.S., Ph.D.
Chandrakala Puligilla, Ph.D.
Demetri D. Spyropoulos, Ph.D.
Elena Tourkina, Ph.D.
Paula Traktman, Ph.D.
Andy Wessels , Ph.D.
Elizabeth Yeh, Ph.D.
|Tanjina Akter||Ran Jing||Aye Mon|
|Xinh-Xinh Nguyen||Charles Reese|