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College of Graduate Studies

Cell Regulation

Steven A. Rosenzweig, Ph.D. - Division Director

Cell regulation encompasses all the functions cells carry out to maintain homeostasis, in particular their responses to extracellular signals (hormones, neurotransmitters, etc.) and how they produce an intracellular response. In addition to these endogenous agents, many drugs and environmental agents use these same mechanisms to produce their most important effects. Numerous research opportunities exist within this program ranging from studies exploring new cell signaling mechanisms, to those examining basic the aberrant signaling mechanisms associated with disease states. Significantly, many of the recent breakthroughs in drug development stem from basic studies on signaling molecules.

The Cell Regulation program is comprised of over 30 faculty members whose research interests and expertise is related to cell regulation. In addition to a track-specific Cell Regulation Journal Club, advanced courses in Cell Signaling are available to students who select this track as their major emphasis.

Cell Regulation Course Descriptions

MCBP-725D Topics in Cancer Research
Two presentation formats will be used for the course. Initially, a faculty member will introduce and direct all students in the discussion of selected literature concerning a single topic. Subsequent topics will be presented by individual students in Journal Club style. Students will present selected papers 2 times during the course and will be active discussants when other students are presenting.
Topics to be covered include:

Tumor Suppressor Genes
Genomic Instability
Metastasis
ECM and Tumor Invasion
Cell Adhesion
Signal Transduction
Telomerase
Mismatch Repair
Apoptosis
Angiogenesis
Immune Evasion and Tumor Immunology
Transforming Growth Factor Beta
Drug Resistance
Transgenic and Knockout Analysis


Prerequisites: None.
Credits: 3 (Pass/Fail)
Rosenzweig and Watson

MBIM-782 Tumor Immunology & Immunotherapy
Prerequisites: None.
Credits: 3
Tomlinson and Sebastiano Gattoni-Celli

MCBP-742 Advanced topics in Cell Signaling
The vast majority of human diseases involve defects in cellular communication and therapeutic intervention often targets molecules involved in cell signaling. This course will dissect signaling cascades and their alterations in disease states addressing cutting edge issues. The course will be offered each Fall with emphasis on cell signaling defects/mutations which may lead to cancer. Course participants will be expected to review the current literature to understand how signaling events are affected and how signaling dysfunction contributes to the onset or progression of the disease and how signaling events might be targeted in a therapeutic attack on the disease. Guest faculty will be invited to describe their research on cell signalling. Oral presentations by course participants will be required. The course is intended for advanced graduate and postgraduate students.
Prerequisites: None
Credits: 3
Kurtz

Cell Regulation Faculty

Zsolt Ablonczy, Ph.D.
Associate Professor
Department of Ophthalmology
RPE cell biology, age-related macular degeneration, mass spectrometry

John E. Baatz, Ph.D.
Professor
Department of Pediatrics, Division of
Neonatology
Non-receptor mediated endocytic mechanisms

Craig Beeson, Ph.D.
Associate Professor
Drug Discovery and Biomedical Science
Regulation of bioenergetics

Narayan R. Bhat, Ph.D.
Professor
Department of Neurology
Glial cell differentiation and myelinogenesis; MAP Kinases in neurodevelopmental and neuroinflammatory cell signaling

Amy Bradshaw, Ph.D.
Associate Professor of Medicine
Role of Extracellular Matrix in the Regulation of  Cell Behavior

Lee Chao, Ph.D.
Professor, Biochemistry and Molecular Biology
Eukaryotic gene structure, function, regulation, and evolution

Kenneth D. Chavin, M.D., Ph.D.
Professor
Department of Surgery
Liver transplantation, liver regeneration, and mitochondrial uncoupling proteins

Craig Crosson, Ph.D.
Professor and Vice Chairman for Research
Department of Ophthalmology
Cell signaling system associated with growth factors and GPCR

L. Ashley Cowart, Ph.D.
Assistant Professor
Biochemistry and Molecular Biology
Regulation of sphingolipid biosynthesis; sphingolipid-mediated transcriptional regulation; diabetic myopathy and muscle wasting

Stephen Ethier, Ph.D.
Professor, Endowed Chair
Pathology & Laboratory Medicine
Growth Factor/Receptor Interactions, Regulation of Cell Growth Proliferation

Weiman Fan, M.D., M.P.H.
Professor
Department of Pathology and Laboratory Medicine
Cell growth regulation, cellular aging, and apoptosis

Andrew Gelasco, Ph.D.
Assitant Professor
Redox signaling in mesangial cells. Receptor
 phosphorylation and desensitization


Gary Gilkeson, M.D.
Professor
Division of Rheumatology
Control of the inflammatory response

Monika Gooz, M.D., Ph.D.
Associate Professor
Department of Medicine
Crosstalk among Growth Factors, ADAMs and Integrins

Stanley R. Hoffman, Ph.D.
Professor
Rheumatology/Immunology
Signaling mechanisms induced by specific ECM proteins and MMP's

Philip Howe, Ph.D.
Professor and Chair
Biochemistry and Molecular Biology
Signaling pathways activated by TGFB1 and Wnt and their potential cross-talk in cellular models of differentiation and cancer

Jennifer Isaacs, Ph.D.
Associate Professor
Dept of Pharmacology
Role of cancer secreted chaperones as mediators of tumor promotion and metastasis

Keith Kirkwood, Ph.D .
Associate Dean for Research
Professor
College of Dental Medicine
P38/MK2 /signaling and post transcriptional mRNA regulation

 

 

 

Masahiro Kono, Ph.D.
Associate Professor
Department of Ophthalmology
Structure and Function of G protein-coupled receptors

Yiannis Koutalos
Professor
Department of Ophthalmology
Sensory signal transduction and cell biology of visual receptor neurons; regulation of cell metabolism

Dhandapani Kuppuswamy, Ph.D.
Associate Professor
Department of Medicine, Division of Cardiology
Mechanism of focal complex formation following integrin activation and the role of this complex in altering cell architecture and survival

Donald R. Menick, Ph.D.
Professor
Department of Medicine, Division of Cardiology
Signal transduction pathways mediating gene expression

Thomas A. Morinelli, Ph.D.
Assistant Professor
Medicine/Nephrology
G Protein-Coupled Receptor Trafficking
  

Robin C. Muise-Helmericks, Ph.D.
Associate Professor
Department of Regenerative Medicine & Cell Biology
Hollings Cancer Institute
Role of the Ets family of transcription factors in angiogenesis and lymphoid development

Anna-Liisa Nieminen, Ph.D.
Associate Professor
Drug Discovery and Biomedical Science
Mechanisms of photodynamic therapy, Thiol-dependent sensitization of tumors to hypoxic cell killing

Besim Ogretmen, Ph.D.
Professor
Department of Biochemistry and Molecular Biology
Regulation of cell growth by novel ceramide and reulation of telomerase

Visu Palanisamy, Ph.D.
Assistant Professor
Craniofacial Biology
Regulation of mRNA stability mechanisms in oral cancer

Chandrakala Puligilla, Ph.D.
Assistant Professor
Pathology & Laboratory Medicine
Molecular Induction, Cellular Fate Specification and Patterning of the Mammalian Auditory System

Baerbel Rohrer, Ph.D.
Professor
Opthalmology
Retinal development and genetics of retinal degeneration

Steven A. Rosenzweig, Ph.D.
Professor
Cell and Molecular Pharmacology
Tumorigenesis, angiogenesis, hypoxia-inducible factor, IGF-binding proteins, receptor tyrosine kinases, and protein:protein interactions

Rick G. Schnellmann, Ph.D.
Professor and Chair
Drug Discovery and Biomedical Science
Signaling pathways of cell injury, death (apoptosis and necrosis) in epithelial and cancer cells, and regeneration of epithelial cells following injury

Adam J. Smolka, Ph.D.
Professor
Department of Medicine
Host/pathogen interactions

Elena Tourkina, Ph.D.
Assistant Professor
Department of Medicine, Division of Rheumatology & Immunology
Role of Caveolin-1 during lung fibrosis and inflammation in Scleroderma and other Intenstitial lung diseases

Dennis K. Watson, Ph.D.
Professor
Laboratory of Cancer Genomics
Pathology & Laboratory Medicine
Transcriptional and post-transcriptional regulation

Xuejun Wen, M.D., Ph.D.
Assistant Professor
Department of Regenerative Medicine & Cell Biology
Stem cell differentiation under environmental cues

Elizabeth Yeh, Ph.D.
Assistant Professor
Department of Cell and Molecular Pharmacology and Experimental Therapeutics
Growth factor receptors, Protein Kinase Signaling, Cell death/survival mechanisms

 
 
 

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