College of Graduate Studies
Steven A. Rosenzweig, Ph.D. - Division Director
Cell regulation encompasses all the functions cells carry out to maintain homeostasis, in particular their responses to extracellular signals (hormones, neurotransmitters, etc.) and how they produce an intracellular response. In addition to these endogenous agents, many drugs and environmental agents use these same mechanisms to produce their most important effects. Numerous research opportunities exist within this program ranging from studies exploring new cell signaling mechanisms, to those examining basic the aberrant signaling mechanisms associated with disease states. Significantly, many of the recent breakthroughs in drug development stem from basic studies on signaling molecules.
The Cell Regulation program is comprised of over 30 faculty members whose research interests and expertise is related to cell regulation. In addition to a track-specific Cell Regulation Journal Club, advanced courses in Cell Signaling are available to students who select this track as their major emphasis.
Cell Regulation Course Descriptions
MCBP-725D Topics in Cancer Research
Two presentation formats will be used for the course. Initially, a faculty member will introduce and direct all students in the discussion of selected literature concerning a single topic. Subsequent topics will be presented by individual students in Journal Club style. Students will present selected papers 2 times during the course and will be active discussants when other students are presenting.
Topics to be covered include:
|Tumor Suppressor Genes|
ECM and Tumor Invasion
Immune Evasion and Tumor Immunology
Transforming Growth Factor Beta
Transgenic and Knockout Analysis
Credits: 3 (Pass/Fail)
Rosenzweig and Watson
MCBP 748/BMB 748 Lipids in Pathobiology
This multidisciplinary course addresses biochemical, applied, and translational approaches to the study of lipids. The course is composed of three main sections: lipid biosynthesis, lipid signaling, and lipids and disease. The first section is a comprehensive treatment of nomenclature and synthesis of major lipid classes including glycerophospholipids, sphingolipids, and sterols, as well as methodology for lipid study. The second section addresses roles of bioactive members of these lipid classes in regulation of cell signaling and downstream events. The third section is largely translational, with many lectures on human diseases that involve the lipids and signaling pathways discussed. This course contains a brief hands-on laboratory segment. This course is open this to graduate students, residents, postdocs, and third and fourth medical students.
Director: Samar M. Hammad (Co-Director: Ashley Cowart)
Offered every two years in the Spring
MBIM-782 Tumor Immunology & Immunotherapy
Tomlinson and Sebastiano Gattoni-Celli
MCBP-742 Advanced topics in Cell Signaling
The vast majority of human diseases involve defects in cellular communication and therapeutic intervention often targets molecules involved in cell signaling. This course will dissect signaling cascades and their alterations in disease states addressing cutting edge issues. The course will be offered each Fall with emphasis on cell signaling defects/mutations which may lead to cancer. Course participants will be expected to review the current literature to understand how signaling events are affected and how signaling dysfunction contributes to the onset or progression of the disease and how signaling events might be targeted in a therapeutic attack on the disease. Guest faculty will be invited to describe their research on cell signalling. Oral presentations by course participants will be required. The course is intended for advanced graduate and postgraduate students.
Cell Regulation Faculty
Zsolt Ablonczy, Ph.D.
John E. Baatz, Ph.D.
Craig Beeson, Ph.D.
Narayan R. Bhat, Ph.D.
Lee Chao, Ph.D.
Weiman Fan, M.D., M.P.H.
Monika Gooz, M.D., Ph.D.
Philip Howe, Ph.D.
Jennifer Isaacs, Ph.D.
Masahiro Kono, Ph.D.
Dhandapani Kuppuswamy, Ph.D.
Chandrakala Puligilla, Ph.D.
Department of Medicine, Division of Rheumatology & Immunology
Role of Caveolin-1 during lung fibrosis and inflammation in Scleroderma and other Intenstitial lung diseases
Dennis K. Watson, Ph.D.
Laboratory of Cancer Genomics
Pathology & Laboratory Medicine
Transcriptional and post-transcriptional regulation
Elizabeth Yeh, Ph.D.