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College of Graduate Studies

First Annual Cardiovascular Training Grant Retreat

January 14-15, 2011
Gazes Cardiac Research Institute, Room 125

Friday, January 14, 2011

4:00 pm

Keynote Speaker

Elizabeth Murphy, Ph.D.
Head, Cardiac Physiology Section
Vascular Medicine Branch
Bethesda, Maryland

 Title:  "Role of S-Nitrosylation in Cardioprotection"

5:00 pmPosters with beer, wine and hors d’oeuvres
Saturday, January 15, 2011
 9:00 a.mContinental Breakfast
 9:30 a.mIntroduction:  Donald R. Menick, Ph.D. - Director
9:45 a.m

Brent Wilkerson
Mentor:  Dr. Kelly Argraves

Title:  “HDL Carried Sphingosine-1-Phosphate Prolongs Endothelial Barrier Function Compared to Albumin: Evidence for Carrier-Specific S1P-Dependent Cell Behavior and Signaling”

10:00 a.m

Jason Funk
Mentor:  Dr. Rick Schnellmann

Title:  “Alterations in Mitochondrial Proteins, Dynamics, and Biogenesis   Following Acute Kidney Injury”
10:15 a.m

Brian Snarr
Mentor:  Dr. Andy Wessels

Title:  “Paradigm Shift in Atrioventricular Septal Defect (AVSD) Pathogenesis
10:30 a.mBreak for Posters and Refreshments
10:45 a.m

Ryan Kendall, Ph.D.
Mentor:  Dr. Lou Luttrell

Title:  Biased Agonism of the Angiotensin AT1 Receptor Regulates Protein Phosphorylation and Prostaglandin Synthesis
11:00 a.m

Jean Ruddy, M.D.
Mentor:  Dr. John Ikonomidis

Title:  “Differential Effects of Mechanical and Biological Stimuli on Matrix Metalloproteinase Promoter Activation in the Thoracic Aorta”
11:15 a.m

Rick Peterson, Ph.D.
Mentor:  Dr. Donald Menick

Title:  “Histone Deacetylases Facilitate Sodium/Calcium Exchanger Upregulation in Adult Cardiomyocytes”

11:30 a.mBreak
11:45 a.m

Keynote Speaker
Wally J. Koch, PhD, FAHA
W.W. Smith Professor of Medicine
Director, Center for Translational Medicine
Vice Chairman for Research, Department of Medicine
Jefferson Medical College
Philadelphia, Pennsylvania

Title:   "Novel Roles for GRKs in Cardiac Signaling and Function” 

 12:45 p.mLunch

Poster Presentations by Past and Present Fellows

Kelley Argraves (6/1/1998-5/31/2000)
Mentor:  Dr Yusuf Hannun
Title:  “Sphingosine-1-Phosphate Receptor, Gpr63: A New Player in Neovascularization”

Lauren Ball (1/26/2003-1/25/2005)
Mentor:  Dr. Maria Buse
Title:  "O-GlcNAc Transferase: A Modulator and Effector of Insulin Signaling"

Olga Chernysh (8/1/2009-present)
Mentor:  Dr. Donald Menick
Title:  “Role of p38/Akt Signaling Pathway in the Regulation of Sodium/Calcium Exchanger Expression in Adult Cardiomyocytes”

Kathryn Cribben (8/1/2010-present)
Mentor:  Dr. Paul McDermott
Title:  “The Role of Estrogen-Related Receptors in Cardiomyocyte Metabolic Adaptation to Oxidative Stress”

Brook J Damon (11/1/2006-2/31/2009)
Mentor: Dr. Robert Thompson
Title: "Cardiac Ca2+ Signaling in Mice with Mutated RyR2 Ca2+ Release Channels"

Shaina Eckhouse (6/5/2010-present)
Mentor:  Dr. Frank Spinale
Title:  “Region Specific Substrate Processing and microRNA Regulation of a Transmembrane Protease with Ischemia Reperfusion Injury--Relationship to Myocardial Dysfunction”

Denise M. Kimbrough (6/1/2010-present)
Mentor:  Dr. Donald Menick
Title:  “K63-Linked Ubiquitinated HDAC5 Remains Nuclear and Upregulates Ncx1 in Cardiac Hypertrophy”

Steve Kubalak (4/1/1991-3/31/1992)
Mentor:  Dr. Jerry Webb
Title:  “Subcellular Localization of Activated p38 and Smad2 in Isolated Dispersed Embryonic Heart Cell Lineages in Response to TGFbeta2 and 9-cis Retinoic Acid”

Amanda LaRue (6/1/2003-5/31/2005)
Mentor:  Dr. Makio Ogawa
Title:  “MCP-1 Directed Regulation of Hematopoietic Cell-Derived Circulating Fibroblast Precursors in Solid Tumors”

Mona S. Li (6/1/2009-present)
Mentor:  Dr. Donald Menick
Title:  “Role of Nkx2.5 Acetylation by Histone Deacetylases in Regulating Sodium/Calcium Exchanger Expression in Adult Cardiomyocytes”

Marie Lockhart (8/1/2009-present)
Mentor:  Dr. Andy Wessels
Title:  “Transcriptional Regulation of Cartilage Link Protein”

John C. McKillop (8/1/2009-present)
Mentor:  Dr. Dhan Kuppuswamy
Title:  “Acute Rapamycin Treatment Augments both Protein Ubiquitination and Akt Activation in Pressure-Overloaded Rat Myocardium”

Thomas Morinelli (6/23/1987-6/22/1990)
Mentor:  Dr. Perry Halushka
Title:  “Angiotensin II (AII)-Induced AT1A Receptor Internalization and Subsequent Increased Cyclooxygenase 2 (COX-2) Protein Expression in Rat Aortic Vascular Smooth Muscle Cells (RASMC) is Mediated by NF-kB Activation”

Tereance  A. Myers (6/25/2010-present)
Mentor:  Dr. Robert Gourdie
Title:  “Epithelial-Mesenchymal Transition Priming of Stem Cells as an Approach to Promoting Scarless, Regenerative Healing in Vivo”

Kathryn Alexa Orr (8/1/2009-present)
Mentor:  Dr. Lina Obeid
Title:  “Characterization of a Novel Sphingosine Kinase Inhibitor"

Nathan Pruett (8/1/2006-7/31/2008)
Mentor:  Dr. Alexander Awgulewitsch
Title:  “Functional Relevance of Hox-specified Positional Identities in Adult Vasculature”

Janet Saunders (5/15/2010-present)
Mentor:  Dr. Craig Beeson
Title:  “Flow Cytometric Characterization of Mitochondrial Subpopulations in the Kidney”

J. Grace Wallenborn (7/6/2009-present)
Mentor:  Dr. George Cooper
Title:  “Adenosine Prevents Microtubule Network Densification During Decompensated Cardiac Hypertrophy Through p21-Activated Kinase 1 (Pak1) Inhibition”


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