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College of Graduate Studies

CGS 701/702 Unit Syllabi

Quicklist

Chemistry of Life Processes (CGS 701O)

Dr. Craig Beeson
QF 309C, 876-5091
beesonc@musc.edu

DateLecturesFlexInstructor

Wed Aug 20

1. Molecular Structure

Tinker Toys

Beeson

Thu Aug 21

1. Chemical Reactivity Assignment #1 Handout

Structure & Reactivity Questions

Beeson

Fri Aug 22

1. Solvation and Electrostatics

 Beeson

Mon Aug 25

1. Biological thermodynamics & kinetics
2. Overview of bioenergetics & redox

 

Beeson

Tue Aug 26

1.Lipids, bilayers & membranes
2.Transporters & channels

Assignment 1 Due

Beeson

Wed Aug 27

1. Mechanisms in Glycolysis
2. Stuctural Aspects of Regulation Assignment #2 Handout

 Beeson

Thu Aug 28

1. Electron transport chain
2. Chemiosmotic energy transduction & Oxidative Phosphorylation
 Lemasters
Fri Aug 291. Beta oxidation & citric acid cycle
2. Mitochondrial physiology
Assignment 2 DueLemasters
Mon Sep 1NO CLASS (Labor Day)  
Tue Sep 21. Regulation of catabolism versus anabolism
2. Signaling in regulation of metabolism
 Beeson
Wed Sep 3Mitochondrial Dysfunction in Disease Chan
Thu Sep 4Probing Metabolism in vitro and in vivoReviewBeeson

Fri Sep 5

UNIT EXAM  

Faculty

Craig Beeson, Ph.D., Drug Discovery and Biomedical Sciences
Sherine Chan, Ph.D., Drug Discovery and Biomedical Sciences
John J. Lemasters, MD, Ph.D., Drug Discovery and Biomedical Sciences, Biochemistry and Molecular Biology

General Reading

 Lehninger (5th ed)Stryer
(7th ed)
Intro to Metabolism
14
14
Bioenergetics
13
 
Lipids, membranes
10
12
Ion channels
11
13
Glycolysis
14, 15
16
TCA
16
17
Oxidative-Phosph
19
18
Fatty Acid Oxidation
17
22
Pentose Phosphate
15
20
Pathway (HMP-shunt)
Gluconeogenesis
14-15
16
Glycogen Synthesis
15
21
Glycogen Catabolism
15
21
Fatty Acid Synthesis
17
22

Useful Websites:

http://www.bmb.leeds.ac.uk/illingworth/oxphos/
http://www.esf.edu/efb/course/EFB325/default.htm
http://www.aw-bc.com/mathews/
http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/MB1index.html

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Macromolecules: Proteins (CGS 701L)

Dr. Scott Eblen
BSB 313F; 792-8367
eblen@musc.edu

DateLecturesFlexInstructor

Mon Oct 26

Protein Properties and Expression

Paper discussionEblen

Tues Oct 27

Protein Modifications

Paper discussion

Eblen

Wed Oct 28

Protein Folding and StabilityChan & Dill PaperBeeson/Isaacs

Thurs Oct 29

Protein-Protein Interactions

Paper discussion

Hsu

Mon Nov 2

Purification

Flex ActivityHsu

Tue Nov 3

Enzyme KineticsKinetics questionsBeeson
Wed Nov 4Enzymes and CatalysisFlex Activity

Olsen

Thurs Nov 5

Principles of X-ray CrystallographyFlex Activity

Olsen

Mon Nov 9

Protein Mass SpectrometryFlex activityBall

Thurs Nov 12

Unit Exam  

Faculty

Scott Eblen, Ph.D., Cell and Molecular Pharmacology & Experimental Therapeutics
Craig Beeson, Ph.D., Drug Discovery and Biomedical Sciences
Jennifer Isaacs, Ph.D., Cell and Molecular Pharmacology & Experimental Therapeutics
Yi-Te Hsu, Ph.D., Biochemistry and Molecular Biology
Shaun Olsen, Ph.D., Biochemistry and Molecular Biology
Lauren Ball, Ph.D., Cell and Molecular Pharmacology & Experimental Therapeutics

General reading Prerequisite readings for this Unit are Chapters 2, 3, 6, 10.3, 10.4, 23.2 and 23.3 in Stryer, 6th Ed; or Chapters 2, 3, 8, 9, 10, 23.1, 23.2, 30.4 and 30.5 in Stryer, 7th Ed.

All assignments are due by 10:00 am on the assigned date: bring completed assignments to class. Read assigned papers before class and be prepared to discuss them.
 

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Receptors & Signaling (CGS 701G)

Dr. Steven A. Rosenzweig
BSB 313G; 792-5841
rosenzsa@@musc.edu

DateLecturesFlexInstructor

Mon Nov 16

Overview of receptors & signaling

Methods in cell signaling

Rosenzweig

Tues Nov 17

Receptor tyrosine kinases in Cancer

Paper discussion (1)

Rosenzweig

Wed Nov 18

G protein coupled receptors

Paper discussion (2)

Blumer

Thurs Nov 23

G proteins and their regulatory proteins

Paper discussion (3)

Blumer

Tues Nov 24

Photoreceptors

Paper discussion (4)

Koutalos

Wed Nov 25

Protein: protein interactions in signal transduction

Methods for identifying/studying protein interactions

Ball

Mon Nov 30

The Pl3 Kinase signaling pathway in diseasePaper discussion (5)Muise-Helmericks
Tues Dec 1Protein kinases: MAP kinasesPaper discussion (6)Eblen
 
Wed Dec 2Cell signaling in response to hypoxiaPaper discussion (7)Isaacs
 

Fri Dec 4

Unit Exam  

Faculty

Steven Rosenzweig, Ph.D., Cell and Molecular Pharmacology
Joe Blumer, Ph.D., Cell and Molecular Pharmacology
Yiannis Koutalos, Ph.D., Ophthalmology
Lauren Ball, Ph.D., Cell and Molecular Pharmacology
Robin Muise-Helmericks, Ph.D., Regenerative Medicine and Cell Biology
Scott Eblen, Ph.D., Cell and Molecular Pharmacology
Jennifer Isaacs, Ph.D., Cell and Molecular Pharmacology

General reading

Prerequisite: Chapters 15, 17 & 20 of Molecular Biology of the Cell, 5th Ed, Alberts et al.

Specific Reading

Papers will be posted on Moodlerooms as required

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Macromolecules: Nucleic Acids (CGS 701K)

Dr. Tilman Heise
BSB 507; 792-6979
heise@musc.edu

DateLecturesFlexInstructor

Mon Sept 14

IIntroduction to Unit

Organization of the nucleus
Nucleic Acids I
 

Preparation time for upcoming lectures

Heise

 

Tues Sept 15

Nucleic Acids II, PCR, RT-PCR
Catalytic RNA
ProjectHeise

Wed Sept 16

Aptamers and Long Non-coding RNAsIn-Unit assignment
Project
Heise

Mon Sept 21

1. Prokaryotic DNA replication
2. Eukaryotic DNA replication
Techniques in DNA replicationMohanty

Tues Sept 22

1. DNA Damage and Checkpoints
2. DNA Repair and Recombination
In-Unit assignment: QuizMohanty

Wed Sept 23

1. In vitro mutagenesis
2. Genome editing

 Kurtz

Mon Sept 28

1. Genomics & Information Resources
2. Next Generation Sequencing
Paper discussionBarth

Tues Sept 29

RNA VirusesProjectSommer

Wed Sept 30

DNA Viruses

Project

Heise

Fri Oct 2

Unit Exam  

Faculty

Jeremy Barth, Ph.D., Regenerative Medicine and Cell Biology
Tilman Heise, Ph.D., Biochemistry and Molecular Biology
David Kurtz, Ph.D., Pharmacology and Experimental Therapeutics
Bidyut Mohanty, Ph.D., Biochemistry and Molecular Biology
Gunhild Sommer, Ph.D., Biochemistry and Molecular Biology

General reading

Chapters 4-7, Molecular Biology of the Cell, 5th ed., Alberts et al.
Also useful are Chapters 4, 5, 28, 29 & 30 in Stryer, 6th ed. Principles in Virology

Grading: 25% of the Unit grade will derive from in-Unit assignments, and 75% will derive from the Unit exam (closed-book, in-class).
 

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Regulation of Gene Expression (CGS 701N)

Dr. David T. Kurtz
BSB 319F; 792-5844
kurtzdt@@musc.edu

DateLecturesFlexInstructor

Mon Oct 5

Prokaryotic transcriptional regulation

Discussion of student presentations:
Molecular Biology Techniques I

Kurtz

Tues Oct 6

Eukaryotic Transcription/Regulation of Gene ExpressionTechniques IIKurtz

Wed Oct 7

Integrating Transcriptional Regulation Signaling Events

Epigenetic Regulation of Gene Expression

Transgenic miceKurtz

 Mon Oct 12

HDAC's and HAT's Role in Gene Expression I and II

 Menick

Tues Oct 13

Micro RNAs I and II

 Menick

Wed Oct 14

Regulation of mRNA Processing and Localization I and II

Practice talks

Heise

Thurs Oct 15

Regulation of mRNA Stability and Translation
Regulation of Translation and Degradation
Practice talks Heise

Mon Oct 19

Student presentations of research papers  
Tues Oct 20Student presentations of research papers  
Wed Oct 21Student presentations of research papers
Overview of Exam
 
Fri Oct 23Unit Exam  

Faculty

David Kurtz, Ph.D., Cell and Molecular Pharmacology and Experimental Therapeutics
Donald Menick, Ph.D., Medicine
Tilman Heise Ph.D., Biochemistry & Molecular Biology
 

General Reading

Prerequisite: Chapters 7, 8 and section 6.6 of Lodish et al, 6th ed. Additional reading from recent reviews may be assigned by each lecturer.

In-Unit Assignment and Flex-Times
Primary research papers will be presented and discussed. Each student will select a current paper on gene expression. Selected papers will be submitted for Unit leader approval by Monday, October 12, 2015. The Unit Leader will give guidelines for the presentation and grading criteria during flex time. The students will have a practice session with a TA on October 14 or 15, 2015. This will be done with 3 students and the TA will critique each presentation. In these practice sessions the students will have the opportunity to ask questions and get very good input on their presentation. Students will give their formal presentation to the entire class on October 19, 20 and 21, 2014.

Grading

25% of the Unit grade will derive from in-Unit research paper presentation, and 75% will derive from the Unit exam (closed-book, in-class).

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Immunobiology (CGS 701P)

Dr. Carl Atkinson
BSB 214B, 843-792-1716
atkinsoc@musc.edu

DATELecturesFlexInstructor
Mon Dec 7Introduction to Immune system – Structure Function.

Methods: Immunopathology
(Atkinson)

Atkinson
Tue Dec 8Innate Immunity
Review Study Session
 
Atkinson
Wed Dec 9TLR/Inflammasomes (Guo)POPs learning assignment
(Atkinson, Assignment 1)
Guo/Atkinson
Thurs Dec 10The recognition of antigen/The generation of lymphocyte AG Receptors (Paulos)Methods: Flow Cytometry
(Soloff)
Paulos/Soloff
Fri Dec 11Ag Presentation to lymphocytes/signal transduction (Haque)Paper Reviews (Atkinson)Haque/Atkinson
Mon Dec 14Development and survival of lymphocytesMethods: T cell Assays
 
Rubinstein
Tues Dec 15B cell activation and Ig isotype distribution and function (Sutkowski)Antibody Assignment
(Kasman, Assignment 2)
Sutkowski/Kasman
Wed Dec 16B cell tolerance (sutkowski)Review Study Session (Atkinson)Sutkowski/Atkinson
Thurs Dec 17Immunology and Disease (Li)Review Study Session (Atkinson)Li/Atkinson
Mon Dec 21Unit Exam  

Faculty

Carl Atkinson, Ph.D., Microbiology and Immunology
Beicho Guo, Ph.D., Microbiology and Immunology
Chrystal Paulos, Ph.D., Microbiology and Immunology
Adam Soloff, Ph.D., Microbiology and Immunology
Laura Kasman, Ph.D., Microbiology and Immunology
Natalie Sutkowski, Ph.D., Microbiology and Immunology
Mark Rubinstein, Ph.D., Surgery/Microbiology and Immunology
Aziz Haque, Ph.D., Microbiology and Immunology
Zihai Li, Ph.D., Microbiology and Immunology

General Reading and Resources

Immunobiology, 7th ed (2008) Charles A. Janeway et al.
Cellular and Molecular Immunology, 7th ed (2011) Abul K. Abbas et al.
The Immune System, 3rd ed (2009) Peter Parham

On-line Resource:
Dr. Harris Goldstein Immunology Lecture Mini-Course
Albert Einstein College of Medicine
http://www.einstein.yu.edu/video/?SCID=23&ts=conferences#top

Specific Reading
Papers will be posted on Moodlerooms as required.

Flex-Time
Will focus on presentation and discussion of immunological techniques to build upon the foundations discussed in formal lectures. The aim of these sessions is to explore methodologies in an interactive informal tutorial setting.

Grading
25% of the Unit grade will be derived from two in-Unit assignments carried out in a designated Flex-time session, and 75% will be derived from a closed-book, in-class exam.

Learning Objective:
The course aims are to guide the student through the immune system in all its aspects - from anatomy, first engagement of innate immunity, to the generation of the adaptive immune response and its clinical/disease consequences. The course will encompass topics such as the complement system, Toll-like receptors, mucosal immunity, T cell tolerance, B cell function and immune diseases.

Specifically students will learn:

• Differences between innate and adaptive immunity
• Structure, function and cellular constituents of immune system
• Immune programing
• Normal function of immune system
• Immune system and disease
• Introduction to key methods in Immunology

 

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Cellular Functions (CGS 702L)

Dr. Robert Gemmill
HCC 712B; 792-4643
gemmill@@musc.edu

DateLecturesFlexInstructor

Mon Jan 4

1. Brief overview course structure
2. Two background lectures

Integration of growth signals

Cell:Extracellular Matrix Interactions
Sign-up for 1 of 4 presentation topics:

• Integrate growth signals
• MicroRNAs & metastomiRs
• Cell:ECM interactions
• Cell Motility
 

All Faculty
Gemmill & Bradshaw
(50 min each)

Tues Jan 5

Integration of growth signals

Cell:Extracellular Matrix Interactions

Sign-up for 1 of 4 presentation topics
Literature databases

Gemmill (Section I)*

Bradshaw (Section II)

Wed Jan 6

Integration of growth signals

Cell:Extracellular Matrix Interactions

search for papers Literature databasesGemmill (Section II)

Bradshaw (Section I)

Thur Jan 7

Two background lectures
MicroRNAs & metastomiRs

Cell Motility

Finalize group choice!! Techniques disc OR
find papers & choose 2

Findlay & Nasarre
(50 min each)

Mon Jan 11


MicroRNAs & metastomiRs

Cell Motility

Submit group papers to relevant instructors 

Findlay (Section I)

Nasarre (Section II)

Tues Jan 12


MicroRNAs & metastomiRs

Cell Motility

Paper decision!!
Work on presentations

Findlay (Section II)

Nasarre (Section I)

Wed Jan 13

In Class review of materials, experiments, papers Work on presentationsFaculty and Students
All Faculty present
Mon Jan 18MLK Day - no class  

Tues Jan 19

Student Presentations (first two groups)

 

Students
All Faculty present

Wed Jan 20

Student Presentations (last two groups) Students
All Faculty present

Fri Jan 22

Unit Exam

  

*Class divided into two sections

Faculty

Amy Bradshaw, PhD (bradshad@musc.edu) Regenerative Medicine and Cell Biology
Victoria Findlay, PhD (findlay@musc.edu) Department of Pathology and  Laboratory Medicine
Robert Gemmill, PhD (gemmill@musc.edu) Department of Medicine
Patrick Nasarre, PhD (nasarre@musc.edu) Department of Medicine
 

General Reading
Chapters 13, 14, 17-20, 22 and 25 Molecular Cell Biology, 6th edition, Lodish

Specific Reading
Papers will be posted on Moodlerooms before the relevant lecture.  Students are to read and complete the Journal Article Worksheet and bring two copies to class.

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Cell Injury and Response (CGS 702I)

Dr. Julie Woolworth Hirschorn
Children's Hospital, EH 222B, 792-1181
woolworj@@musc.edu

DateLecturesFlexInstructor

Mon Jan 25

Unit Introduction

Cell Injury Part 1: Mechanisms and Response

Flex-Time: Discuss and sign-up for Technique Rotations

Woolworth

Tues Jan 26

Cell Injury Part II: Adaptations and Cell DeathIn-Unit activity #1 Woolworth

Wed Jan 27


Techniques Exposure (Attendance Required)
 Core Facilities at MUSC

Mon Feb 1

Inflammation

In-class activity #2: Article Discussion 

Woolworth

Tues Feb 2

Microbes: Friend or FoeIn-class activity #3Westwater

Wed Feb 3

Genetics

In-class activity #4

Wolff

Mon Feb 8

Hypersensitivity

 

Self

Tues Feb 9

Asthma

In-class activity #5

Atkinson

Wed Feb 10


All Day - Techniques
Presentations from Groups
Technique papers due 9:00 am 

Fri Feb 12

Unit Exam

 

 

Faculty

Julie Woolworth Hirschhorn, PhD (woolworj@musc.edu)  Pathology and Laboratory Medicine
Caroline Westwater (westwatc@musc.edu) Oral Health Sciences
Daynna Wolff, PhD (wolffd@musc.edu) Pathology and Laboratory Medicine
Sally Self, MD (selfs@musc.edu)  Pathology and Laboratory Medicine
Carl Atkinson, PhD (atkinsoc@musc.edu) Microbiology and Immunology

 

Learning Objectives 
The overall objective of this unit to help you understand the etiology, mechanism, and consequences of cell injury. Each Lecturer will provide 3-4 objectives for their lecture. These objectives can be found in the PDF file “2016 Unit Objectives” on Moodle.

General reading

Robbins and Cotran Pathologic Basis of Disease, Ninth Edition.
• For more details on Cell Injury and Inflammation (Dr. Woolworth), please read from the relevant sections in Chapters 2 & 3.
• For more details on Microbiology (Dr. Westwater), please read from chapter 2, section on “infectious agents”. For additional details, read from chapter 8.
• For more details on Genetics (Dr. Wolff), please read the section on “Genetic Derangements” in Chapter 2. For additional details, read from chapter 5.
• Prior to the lecture on Hypersensitivity (Dr. Self), please read the four sections from chapter 6: “Hypersensitivity: Immunologically Mediated Tissue Injury”, “Classification of Hypersensitivity Diseases”, “Autoimmune Diseases”, and “Mechanisms of Autoimmunity: General Principles”
• Prior to the lecture on Kidney Transplant (Dr. Self), please read the three sections from chapter 6: “Rejection of Tissue Transplants, “Mechanisms of Recognition and Rejection of Allografts”, and “Rejection of Kidney Grafts”

For additional Study Assistance:
The relevant objectives, study points, and review questions have been prepared for you on flashcards available at the Brainscape website or App.
https://www.brainscape.com/study?pack_id=814223

Specific Reading will be posted on Moodlerooms before the relevant lecture and/or assignment.
 

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Human Physiology (CGS 702K)

Dr. Perry Halushka
BE 311; 876-2405
halushpv@@musc.edu

DateLecturesFlexInstructor (email)

Mon Feb 16

Introduction to the Unit
The Heart and Arterial Pressure Control Mechanisms
 Halushka

Tues Feb 17

Renal Physiology Bell

Wed Feb 18

The autonomic nervous system Kurtz

Mon Feb 23

Cardiovascular Diseases/Hypertension

 Lackland

Tues Feb 24

Presentation of Classic Papers TBA

Wed Feb 25

Gastrointestinal Physiology Smolka

Mon Mar 2

Endocrinology Luttrell

Tues Mar 3

Pulmonary Physiology
 
 Koutalos

Wed Mar 4

Pulmonary
Pathophysiology/COPD/Asthma
 Atkinson

Fri Mar 6

Unit Exam  

Faculty

Perry Halushka, Ph.D., M.D., Medicine/Cell and Molecular Pharmacology
P. Darwin Bell, Ph.D., Medicine
David Kurtz, Ph.D., Cell and Molecular Pharmacology
Dan Lackland, DRPH, Neuroscience
Adam Smolka, Ph.D., Medicine
L. Luttrell, M.D., Ph.D., Medicine
Ioannis Koutalos, Ph.D., Ophthalmology
Carl Atkinson, Ph.D., Microbiology and Immunology

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