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Department of Microbiology and Immunology

Azizul Haque, PhD

Haque PictureAssociate Professor
Microbiology and Immunology

1997-2003 Postdoctoral Fellow, Indiana University School of Medicine

1997 Ph.D., Saga Medical School, Japan

Contact Info
Tel: 843-792-9466
BSB 214E

Research Interests

Dr. Haque's laboratory conducts research in the areas of tumor immunology, transplantation immunology and autoimmunity. In tumor immunology, we are investigating the mechanisms by which malignant tumors such as lymphoma, prostate and melanoma evade immune recognition via MHC class I and II pathways. Lymphoid malignancies such as B-cell lymphomas arise at distinct stages of cellular development and maturation, potentially influencing immune recognition and the functional interaction of these cells with other components of the immune system. Burkitt lymphoma (BL) is a highly malignant B-cell tumor characterized by chromosomal translocation that constitutively activates the c-myc oncogene. Epstein-Barr virus (EBV) transforms primary B-cells in vitro, and results in the establishment of lymphoblastoid cell lines (B-LCL). While B-LCL efficiently process and present antigens to T cells in the context of both MHC class I and class II molecules, BL cells have been shown to be deficient in their ability to process and present antigens by both pathways, and the mechanisms remain unknown. Studies in Dr. Haque's laboratory are probing the factors responsible for defective antigen processing and immune recognition in the context of MHC class II molecules. While MHC class I-restricted CD8+ T cells are effector cells in anti-tumor immune responses, MHC class II-restricted CD4+ T cells can also destroy tumors by direct killing. CD4+ T cells can also play critical roles in initiating, regulating, and maintaining anti-tumor immune responses. Because most B-cell tumors express MHC class II molecules, these tumors can be potential target for CD4+ T cells. Elucidating the mechanisms of loss of immune recognition in the context of MHC class II molecules will contribute to the development of effective immunotherapeutics against B-cell lymphomas.

In transplantation immunology, we are investigating the regulation of immune responses in lung allograft rejection using a rat model of lung transplantation. In collaboration with Dr. Wilkes (Indiana University), we have found that the immune responses during lung allograft rejection may be directed against certain connective tissue proteins such as type V collagen. Ongoing studies in the laboratory are actively investigating the implications of collagen V-reactive T cells in the immunopathogenesis of chronic lung allograft rejection. Dr. Haque's laboratory is also investigating the role of small molecules in the suppression of autoimmune diseases.

Recent Publications | Additional Publications

Antimony-Induced Neurobehavioral and Biochemical Perturbations in Mice.
Tanu T, Anjum A, Jahan M, Nikkon F, Hoque M, Roy AK, Haque A, Himeno S, Hossain K, Saud ZA.
Biol Trace Elem Res. 2018 Mar 8. doi: 10.1007/s12011-018-1290-5. [Epub ahead of print]

New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection.
Haque A, Polcyn R, Matzelle D, Banik NL.
Brain Sci. 2018 Feb 18;8(2). pii: E33. doi: 10.3390/brainsci8020033. Review.

Neuron specific enolase is a potential target for regulating neuronal cell survival and death: implications in neurodegeneration and regeneration.
Polcyn R, Capone M, Hossain A, Matzelle D, Banik NL, Haque A.
Neuroimmunol Neuroinflamm. 2017;4:254-257. doi: 10.20517/2347-8659.2017.59. Epub 2017 Dec 6. No abstract available.

Enolase and Acute Spinal Cord Injury.
Polcyn R, Capone M, Hossain A, Matzelle D, Banik NL, Haque A.
J Clin Cell Immunol. 2017;8(6). pii: 536. doi: 10.4172/2155-9899.1000536. Epub 2017 Dec 29. No abstract available.|

Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective.
Bryant JM, Bouchard M, Haque A.
J Clin Cell Immunol. 2017;8(6). pii: 535. doi: 10.4172/2155-9899.1000535. Epub 2017 Dec 12.

A Novel Aza-MBP Altered Peptide Ligand for the Treatment of Experimental Autoimmune Encephalomyelitis.
Trager NNM, Butler JT, Harmon J, Mount J, Podbielska M, Haque A, Banik NL, Beeson CC.
Mol Neurobiol. 2018 Jan;55(1):267-275. doi: 10.1007/s12035-017-0739-4.

Autophagy-dependent crosstalk between GILT and PAX-3 influences radiation sensitivity of human melanoma cells.
Hathaway-Schrader JD, Doonan BP, Hossain A, Radwan FFY, Zhang L, Haque A.
J Cell Biochem. 2018 Feb;119(2):2212-2221. doi: 10.1002/jcb.26383. Epub 2017 Oct 18.

Targeting Enolase in Reducing Secondary Damage in Acute Spinal Cord Injury in Rats.
Haque A, Capone M, Matzelle D, Cox A, Banik NL.
Neurochem Res. 2017 Oct;42(10):2777-2787. doi: 10.1007/s11064-017-2291-z. Epub 2017 May 15.

Individual and Combined Effects of Arsenic and Lead on Behavioral and Biochemical Changes in Mice.
Aktar S, Jahan M, Alam S, Mohanto NC, Arefin A, Rahman A, Haque A, Himeno S, Hossain K, Saud ZA.
Biol Trace Elem Res. 2017 Jun;177(2):288-296. doi: 10.1007/s12011-016-0883-0. Epub 2016 Oct 27.

Multiple Defects Impair the HLA Class II Antigen Presentation Capacity of Burkitt Lymphoma.
God JM, Haque A.
J Clin Cell Immunol. 2016 Aug;7(4). pii: e119. Epub 2016 Aug 5. No abstract available.

Research Support

VA (1I01BX002349-01)                            Banik (PI)                                       04/01/14-03/31/18
Regulation of inflammation and neuroprotection by calpain inhibitor in MS
The goal of this study is to examine the effects of calpain inhibition on Th and Treg cytokine/chemokine profiles and alteration of MDSCs in MS patients, and determine the signaling mechanisms following calpain inhibition.
Role: Co-I

SCIRF #2016 I-03                                     Haque (PI)                                    07/01/16-06/30/18
Neuron-specific Enolase and SCI
The goal of this project is to investigate the role of neuron-specific enolase in spinal cord injury in a rat model of spinal cord injury.
Role: PI

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