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Department of Microbiology and Immunology

Laura Kasman, PhD

Associate Professor, Microbiology and ImmunologyLaura Kasman, PhD
Chair, Master of Biomedical Sciences Program Committee, College of Graduate Studies

Year 2 Curriculum Director, College of Medicine
Co-Director (with Dr. Cynthia Wright) of the Master of Science in Medical Sciences Program
Co-Director of the Post-Baccalaureate Research Education Program (NIH-PREP)                                

1992-1994  Post-doctoral fellow, Massachusettes Institute of Technology, Cambridge, MA                      
1995-1996  Post-doctoral fellow, University of Georgia – Athens, GA                                                           
1998-1999  Visiting Scientist, University of California – Berkeley, CA                                                                                 

Education   1992  Ph.D., Harvard University

Contact Info   kasmanl@musc.edu      Tel: 843-792-8117    Office: BSB 208F (Campus Mail: MSC 504)

Research Interests

I am primarily interested in education research and teaching.  Other interests include different types of virus-virus interactions and maintaining an online public database of such interactions at www.musc.edu/vvi.

Past research focused on maximizing viral vector effectiveness for use in immunotherapy of bladder cancer. This project, in collaboration with Dr. Christina Johnson, involved optimization of conditions for using adenoviral vectors to deliver apoptosis-inducing genes to bladder tumors. We have shown that some histone deacetylase inhibitors increase both adenoviral infection and transgene expression in bladder cancer cells in vitro and a mouse model of bladder cancer. 

Other projects include investigation of the role of androgens in bladder cancer development, and the mechanism of viral hepatitis-induced xerostomia

Recent Publications | Additional Publications

Gosnell H, Kasman LM, Potta T, Vu L, Garrett-Mayer E, Rege K, Voelkel-Johnson C. Polymer-enhanced delivery increases adenoviral gene expression in an orthotopic model of bladder cancer. J Control Release 2014 176:35-43.

Kasman L, Voelkel-Johnson C. An orthotopic bladder cancer model for gene delivery studies. J Vis Exp 2013 (82):50181. doi: 10.3791/50181. 

Kasman L, Onicescu G, and Voelkel-Johnson C. Histone deacetylase inhibitors restore cell surface expression of the coxsackie adenovirus receptor and enhance CMV promoter activity in castration resistant prostate cancer cells. Prostate Cancer 2012, 2012:137163.  Epub 2012 Jan 12.  PMID: PMC3263646.

Murali A*, Kasman L*, Voelkel-Johnson C. Adenoviral infectivity of exfoliated viable cells in urine: implications for the detection of bladder cancer. BMC Cancer 2011, 11:168.
PMID: 21569442

Grewal JS*, Pilgrim MJ*, Grewal S*, Kasman L*, Werner P, Bruorton ME, London SD, London L. Salivary glands act as mucosal inductive sites via the formation of ectopic germinal centers after site-restricted MCMV infection. FASEB J 2011 (5):1680-96. Epub 2011 Feb 9. PMID: 21307334.

DaPalma T, Doonan BP, Trager NM, Kasman LM. A systematic approach to virus-virus interactions. Virus Res 2010 149(1):1-9. Epub 2010 Jan 20. Review. PubMed PMID: 20093154.

Kasman LM, London LL, London SD, Pilgrim MJ. A mouse model linking viral hepatitis and salivary gland dysfunction. Oral Dis 2009 15(8):587-95. Epub 2009 Jul 27. PubMed PMID: 19656314.

Kasman LM, Barua S, Lu P, Rege K, Voelkel-Johnson C. Polymer-enhanced adenoviral transduction of CAR-negative bladder cancer cells. Mol Pharm 2009 6(5):1612-9. PubMed PMID: 19655763; PMCID: PMC2757475.

* equal contribution

Grant Support

MUSC Post-Baccalaureate Research Education Program (1R25GM113278-01)
NIH/NIGMS
1/1/2015-12/31/2019

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