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Department of Microbiology and Immunology

Laura Kasman, PhD

Associate Professor, Microbiology and ImmunologyLaura Kasman, PhD
Chair, Master of Biomedical Sciences Program Committee, College of Graduate Studies

Year 2 Curriculum Director, College of Medicine
Co-Director (with Dr. Cynthia Wright) of the Master of Science in Medical Sciences Program
Co-Director of the Post-Baccalaureate Research Education Program (NIH-PREP)                                

1992-1994  Post-doctoral fellow, Massachusetts Institute of Technology, Cambridge, MA                      
1995-1996  Post-doctoral fellow, University of Georgia – Athens, GA                                                           
1998-1999  Visiting Scientist, University of California – Berkeley, CA                                                                                 

Education   1992  Ph.D., Harvard University

Contact Info   kasmanl@musc.edu      Tel: 843-792-8117    Office: BSB 208F (Campus Mail: MSC 504)

Research Interests

I am primarily interested in education research and teaching.  Other interests include different types of virus-virus interactions and maintaining an online public database of such interactions at http://virusvirus.net/vvi.php.

Past research focused on maximizing viral vector effectiveness for use in immunotherapy of bladder cancer. This project, in collaboration with Dr. Christina Johnson, involved optimization of conditions for using adenoviral vectors to deliver apoptosis-inducing genes to bladder tumors. We have shown that some histone deacetylase inhibitors increase both adenoviral infection and transgene expression in bladder cancer cells in vitro and a mouse model of bladder cancer. 

Other projects include investigation of the role of androgens in bladder cancer development, and the mechanism of viral hepatitis-induced xerostomia

Recent Publications | Additional Publications

Bacteriophages.
Kasman LM, Whitten RA.
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2018 Feb 26.
PMID:29630237

Herpes, Simplex, Neonatorum.
Boyd RL, Kasman LM.
StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-.
2018 Feb 15.
PMID:29261969

Sex differences in the MB49 syngeneic, murine model of bladder cancer.
White-Gilbertson S, Davis M, Voelkel-Johnson C, Kasman LM.
Bladder (San Franc). 2016;3(1). pii: e22. Epub 2016 Feb 26.
PMID:26998503

Polymer-enhanced delivery increases adenoviral gene expression in an orthotopic model of bladder cancer.
Gosnell H, Kasman LM, Potta T, Vu L, Garrett-Mayer E, Rege K, Voelkel-Johnson C.
J Control Release. 2014 Feb 28;176:35-43. doi: 10.1016/j.jconrel.2013.12.012. Epub 2013 Dec 24.
PMID:24370892

An orthotopic bladder cancer model for gene delivery studies
Kasman L, Voelkel-Johnson C
J Vis Exp (82):50181 2013


Histone deacetylase inhibitors restore cell surface expression of the coxsackie adenovirus receptor and enhance CMV promoter activity in castration resistant prostate cancer cells
Kasman L, Onicescu G, and Voelkel-Johnson C
Prostate Cancer 2012:137163.  PMID: PMC3263646

Adenoviral infectivity of exfoliated viable cells in urine: implications for the detection of bladder cancer
Murali A*, Kasman L*, Voelkel-Johnson C.

BMC Cancer 11:168. 2011
PMID: 21569442

Salivary glands act as mucosal inductive sites via the formation of ectopic germinal centers after site-restricted MCMV infection
Grewal JS*, Pilgrim MJ*, Grewal S*, Kasman L*, Werner P, Bruorton ME, London SD, London L
FASEB J (5):1680-96. 2011
PMID: 21307334

A systematic approach to virus-virus interactions.
DaPalma T, Doonan BP, Trager NM, Kasman LM.
Virus Res. 2010 Apr;149(1):1-9. doi: 10.1016/j.virusres.2010.01.002. Epub 2010 Jan 20. Review.
PMID:20093154

A mouse model linking viral hepatitis and salivary gland dysfunction.
Kasman LM, London LL, London SD, Pilgrim MJ.
Oral Dis. 2009 Nov;15(8):587-95. doi: 10.1111/j.1601-0825.2009.01600.x. Epub 2009 Jul 27.
PMID:19656314

Polymer-enhanced adenoviral transduction of CAR-negative bladder cancer cells.
Kasman LM, Barua S, Lu P, Rege K, Voelkel-Johnson C.
Mol Pharm. 2009 Sep-Oct;6(5):1612-9. doi: 10.1021/mp9000958.
PMID:19655763

Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2.
White SJ, Kasman LM, Kelly MM, Lu P, Spruill L, McDermott PJ, Voelkel-Johnson C.
Free Radic Biol Med. 2007 Nov 1;43(9):1313-21. Epub 2007 Jul 3.
PMID:17893044

* equal contribution

Grant Support

MUSC Post-Baccalaureate Research Education Program (1R25GM113278-01)
NIH/NIGMS
1/1/2015-12/31/2019

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