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Department of Microbiology and Immunology

Janardan Pandey, PhD

Pandey PictureProfessor
Microbiology & Immunology

Education
1972  Ph.D., University of Wisconsin, Madison

Contact Info
pandeyj@musc.edu
Tel: 843-792-4360
BSB 753A-B

Research Interests

The primary focus of my laboratory is directed towards understanding the mechanisms underlying the involvement of immunoglobulin Fc (GM) and Fcgamma receptor genes in immunity to various malignant and infectious diseases.  These studies are supported in part by grants and contracts from the National Institutes of Health and the Department of Defense.

Recent Publications | Additional Publications

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.
Gaudinski MR, Coates EE, Houser KV, Chen GL, Yamshchikov G, Saunders JG, Holman LA, Gordon I, Plummer S, Hendel CS, Conan-Cibotti M, Lorenzo MG, Sitar S, Carlton K, Laurencot C, Bailer RT, Narpala S, McDermott AB, Namboodiri AM, Pandey JP, Schwartz RM, Hu Z, Koup RA, Capparelli E, Graham BS, Mascola JR, Ledgerwood JE; VRC 606 Study Team.
PLoS Med. 2018 Jan 24;15(1):e1002493. doi: 10.1371/journal.pmed.1002493. eCollection 2018 Jan.
PMID:29364886

HIV-1 Control and Immunoglobulin Genes.
Pandey JP.
J Infect Dis. 2018 Mar 13;217(7):1170. doi: 10.1093/infdis/jiy021. No abstract available.
PMID:29346629

Endogenous antibody responses to mucin 1 in a large multiethnic cohort of patients with breast cancer and healthy controls: Role of immunoglobulin and Fcγ receptor genes.
Pandey JP, Namboodiri AM, Wolf B, Iwasaki M, Kasuga Y, Hamada GS, Tsugane S.
Immunobiology. 2018 Feb;223(2):178-182. doi: 10.1016/j.imbio.2017.10.028. Epub 2017 Oct 18.
PMID:29074302

Association between γ marker, human leucocyte antigens and killer immunoglobulin-like receptors and the natural course of human cytomegalovirus infection: a pilot study performed in a Sicilian population.
Di Bona D, Accardi G, Aiello A, Bilancia M, Candore G, Colomba C, Caruso C, Duro G, Gambino CM, Macchia L, Pandey JP.
Immunology. 2018 Apr;153(4):523-531. doi: 10.1111/imm.12855. Epub 2017 Dec 11.
PMID:29067686

Immunoglobulin genotypes and cognitive functions in schizophrenia.
Pandey JP, Namboodiri AM, Nietert PJ, Yoshimura R, Hori H.
Immunogenetics. 2018 Jan;70(1):67-72. doi: 10.1007/s00251-017-1030-6. Epub 2017 Sep 22.
PMID:28936707

Rituximab therapy and the highly polymorphic Fc region of IgG: comment on the article by Cartin-Ceba et al.
Pandey JP.
Arthritis Rheumatol. 2017 Nov;69(11):2247. doi: 10.1002/art.40221. No abstract available.
PMID:28743175

Genetic markers of immunoglobulin G and immunity to cytomegalovirus in patients with breast cancer.
Pandey JP, Namboodiri AM, Mohan S, Nietert PJ, Peterson L.
Cell Immunol. 2017 Feb;312:67-70. doi: 10.1016/j.cellimm.2016.11.003. Epub 2016 Nov 2.
PMID:27825564

Kynurenine and Tryptophan Levels in Patients With Schizophrenia and Elevated Antigliadin Immunoglobulin G Antibodies.
Okusaga O, Fuchs D, Reeves G, Giegling I, Hartmann AM, Konte B, Friedl M, Groer M, Cook TB, Stearns-Yoder KA, Pandey JP, Kelly DL, Hoisington AJ, Lowry CA, Eaton WW, Brenner LA, Rujescu D, Postolache TT.
Psychosom Med. 2016 Oct;78(8):931-939.
PMID:27359171

Immunoglobulin G genotypes and the risk of schizophrenia.
Pandey JP, Namboodiri AM, Elston RC.
Hum Genet. 2016 Oct;135(10):1175-9. doi: 10.1007/s00439-016-1706-2. Epub 2016 Jul 8.
PMID:27393575

Significance of FcγRIIIa-V158F Polymorphism-Letter.
Pandey JP.
Clin Cancer Res. 2016 May 1;22(9):2311. doi: 10.1158/1078-0432.CCR-16-0428. No abstract available.
PMID:27141008

Research Support

R21 MH104613                                               Pandey (PI)                                                           04/20/15-07/31/17
Immunoglobulin Genes and Immunoevasion by Neurotropic Viruses in Schizophrenia
This project investigates the role of a major gene of the immune system in the etiopathogenesis of herpesvirus- spurred cognitive impairment. Results from these investigations could help devise novel immunotherapeutic interventions in this devastating disorder.
Role: PI
 

16X109                                                            Pandey (PI)                                                           04/01/16-03/31/18
NIAID/Leidos
GM Allotypes and Human Monoclonal Antibodies Against HIV
This subproject investigates the influence of GM allotypes on the pharmacokinetics of broadly neutralizing HIV- 1 human monoclonal antibodies.
Role: PI

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