Department of Microbiology and Immunology
Janardan Pandey, PhD
1972 Ph.D., University of Wisconsin, Madison
The primary focus of my laboratory is directed towards understanding the mechanisms underlying the involvement of immunoglobulin Fc (GM) and Fcgamma receptor genes in immunity to various malignant and infectious diseases. These studies are supported in part by grants and contracts from the National Institutes of Health and the Department of Defense.
Recent Publications | Additional Publications
Pandey JP, Namboodiri AM. Genetic variants of IgG1 antibodies and FcgRIIIa receptors influence the magnitude of antibody-dependent cell-mediated cytotoxicity against prostate cancer cells. OncoImmunology 2014; 3:e27317.
Pandey JP, Kistner-Griffin E, Black L, Namboodiri AM, Iwasaki M, Kasuga Y, Hamada GS, Tsugane S. IGKC and FcgR genotypes and humoral immunity to HER2 in breast cancer. Immunobiology 2014; 219:113-117.
Pandey JP. Genetic etiology of schizophrenia: possible role of immunoglobulin g genes. Psychiatr Genet 2014; 24:83-86.
Pandey JP, Namboodiri AM, Ohue Y, Oka M, Nakayama E. Genetic variants of immunoglobulin g and k chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer. Clin Exp Immunol 2014; 176:78-83.
Pandey JP, Kistner-Griffin E, Namboodiri AM, Iwasaki M, Kasuga Y, Hamada GS, Tsugane S. Higher levels of antibodies to the tumor-associated antigen cyclin B1 in cancer-free individuals than in patients with breast cancer. Clin Exp Immunol 2014; 178:75-78.
Pandey JP, Namboodiri AM. Immunoglobulin GM and FcgRIIIa genotypes influence cytotoxicity of neuroblastoma cells. J Neuroimmunol 2014; 270:95–97.
Pandey JP, Kaur N, Costa S, Amorim J, Nabico R, Linhares P, Vaz R, Viana-Pereir M, Reis RM. Immunoglobulin genes implicated in glioma risk. OncoImmunology 2014; 3:e28609.
Pandey JP. Immunoglobulin GM genes, cytomegalovirus immunoevasion, and the risk of glioma, neuroblastoma, and breast cancer. Front Oncol 2014; 4:236.
Pandey JP, Kistner-Griffin E, Radwan FF, Kaur N, Namboodiri AM, Black L, Butler MA, Carreon T, Ruder AM. Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B. J Infect Dis 2014; 210:1823-1826.
Pandey JP, Kistner-Griffin E, Radwan FF, Kaur N, Namboodiri AM, Black L, Butler MA, Carreon T, Ruder AM. Endogenous antibody responsiveness to epidermal growth factor receptor is associated with immunoglobulin allotypes and with overall survival of patients with glioblastoma. Neuro-Oncology 2014; doi:10.1093/neuonc/nou298.
Genetic Modifiers of Immune Evasion by Cytomegalovirus in Glioblastoma
Population Genetics Analysis Program
Sub Project: Immunoglobulin Allotypes and Immune Response to Smallpox Vaccine
(A subcontract via Mayo Clinic)
Avon Foundation 01/01/2014-12/31/2015
(Grant No. 02-2013-074)
Role of IGHG, IGKC, and FcgR Genes in the Generation of Immunity to Cytomegalovirus and in Modulating Viral Immunoevasion Strategies in Breast Cancer
(A subcontract through Leidos Biomedical Research, Inc.)
GM Allotypes and Human Monoclonal Antibodies Against HIV
Immunoglobulin Genes and Immunoevasion by Neurotropic Viruses in Schizophrenia