Department of Microbiology and Immunology
Steve Tomlinson, PhD
1990-1991 Postdoctoral Fellow, Dept. of Molecular Biology, University of Florida at Gainesville
1989 Ph.D., University of Cambridge, UK
Complement is a group of over 30 soluble and cell surface proteins that represent a crucial component of both the innate and adaptive immune systems. Research in the laboratory is focused on the biology of the complement system, and how it modulates an inflammatory response and shapes adaptive immunity. Within the context of complement-modulated immunity, areas of study relate to ischemic injury and disease (such as stroke, spinal cord injury and post-transplant ischemia reperfusion injury), alloimmunity (transplant rejection) and cancer immunity. A further area of study is the dual role of complement in liver injury and regeneration, important in the context of liver resection or small-for-size transplant. Integrated within these studies is the development and characterization of various site-targeted strategies for complement inhibition. These strategies (some of which are in clinical development) are being investigated in various mouse models of injury and disease.
Publications (selected from 126) | Additional Publications
He S, Atkinson C, Qiao F, Cianflone K, Chen X, and Tomlinson S. (2009) A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration, and clinical implications. J. Clin. Invest. 119:2304-16.
Atkinson C, Mosely E, Varela JC, Stoica S, Large S, Goddard M, and Tomlinson S. (2009) Complement dependent inflammation and Injury in a murine model of brain dead donor hearts. Circ. Research 105:1094-1101. PMCID: PMC2783176
Khan MA, Jiang X, Beilke J, Holers VM, Atkinson C, Tomlinson S, and Nicolls M. (2011) CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants. Circ. Research 109:1290-301.
Takeda K, Thurman JM, Tomlinson S, Okamato M, Shiraishi Y, Ferreira VP, Cortez C, Pangburn MK, Holers VM, and Gelfand EW. (2012). The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness (AHR) and inflammation. J. Immunol. 188: 661-7.
Elvington A, Atkinson C, Kulik L, Zhu H, Yu J, Kindy MS, Holers VM, and Tomlinson S. (2012) Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. J. Immunol. 188:14660-8.
Schepp-Berglind J, Atkinson C, Elvington M, Qiao F, Mannon P, and Tomlinson S. (2012) Complement-dependent injury and protection in a murine model of acute DSS-induced colitis. J. Immunol. 188:6309-18.
Elvington M, Huang Y, Morgan BP, Qiao F, van Rooijen N, Atkinson C, and Tomlinson S. (2012) A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer. Blood 119:6043-51.
Elvington A, Atkinson C, Zhu H, Yu J, Takahashi K, Stahl GL, Kindy MS, Tomlinson S. (2012). The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J. Immunol. 189:4640-7.
Holers VM, Rohrer B, and Tomlinson S. (2013). CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation. Adv. Exp. Med. Biol. 734:137-54.
Kahn MA, Maasch C, Vater A, Klussmann S, Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS, and Nicolls MR. (2013). Targeting C5a promotes vascular integrity and limits airway remodeling. Proc. Nat. Acad. Sci. 110:6061-6.
Atkinson C, Floerchinger B, Qiao F, Casey S, Williamson T, Mosely E, Stoica S, Goddard M, Ge X, Tullius SG, and Tomlinson S. (2013). Donor brain death exacerbates complement-dependent ischemia reperfusion injury in transplanted hearts. Circulation 127:1290-9.
Elvington M, Blichmann P, Qiao F, Scheiber M, Wadsworth C, Luzinov I, Lucero J, Vertegel A, and Tomlinson S. (2014) A novel protocol allowing oral delivery of a protein complement inhibitor that subsequently targets to inflamed colon mucosa and ameliorates murine colitis. Clin. Exp. Immunol. 177:500-8.
Elvington M, Scheiber M, Yang X, Lyons K, Jacqmin D, Wadsworth C, Marshall D, Vanek K, and Tomlinson S. (2014) Complement dependent modulation of anti-tumor immunity following radiation therapy. Cell Reports 8:818-30.
Marshall KM, He S, Zhong Z, Atkinson C, and Tomlinson S. (2014) Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy. J. Exp. Med. 211:1793-1805.
Title: Complement, anti-tumor immunity and apoptosis-based therapy
Funding Period: 1/1/12-12/31/17
Title: The complement system and spinal cord injury
Agency: Dept. Veteran’s Affairs
Funding Period: 11/15/11-11/14/15
Title: Role of complement in brain death induced injury to donor hearts
Funding Period: 8/1/07-7/31/12
Title: Role of complement in inflammatory bowel disease
Agency: Crohn’s and Colitis Foundation of America
Funding Period: 1/7/10-06/30/13
Title: Complement and cognitive recovery after stroke
Agency: Alexion Pharmaceuticals
Funding Period: 9/1/12-8/31/14
Title: The role of complement in the pathogenesis of emphysema
Funding Period: 3/1/10-2/28/15
Title: Alternative Pathway of Complement Activation in Age-Related Macular Degeneration
Funding Period: 7/01/10-6/30/15
Title: Therapeutic intervention in traumatic brain injury
Agency: Dept. Veteran’s Affairs
Funding Period: 6/1/10-5/31/13