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Department of Microbiology and Immunology

Cynthia F. Wright

Cynthia F. Wright Ph.D.Wright Picture

Associate Professor
Microbiology and Immunology

Education
1985            Ph.D., State University of New York at Albany

Contact Info
wrightcf@musc.edu
Tel: 843-792-2564
BSB 102

Research Interests

1. Vaccinia virus late transcription. Vaccinia virus belongs to the poxvirus family of viruses and contains a large, double-stranded DNA genome. Its genes are divided into early, intermediate and late classes depending on their time of synthesis after host cell infection. Recently, we have identified host cell factors that potentially participate in viral late gene expression. Through protein purification, in vitro transcription assays, and protein:DNA interaction studies we are examining the mechanism of action of these factors.

2. Transcription defects in malignant rhabdoid tumor. Malignant rhabdoid tumor (MRT) is a rare, pediatric cancer that is extremely resistant to chemotherapeutic treatments. Recently, a gene on chromosome 22 was identified that is often disrupted in these tumors and is potentially involved in their formation. The encoded protein, hSNF5/INI1, is part of a high molecular weight chromatin remodeling complex that potentially impacts the transcription of many cellular genes. Using transfection studies we have determined that re-introduction of this gene into MRT cells suppresses their growth. We are currently employing chromatin immunoprecipitation to study the interaction of INI1 at different cellular promoters.

Recent Publications| Additional Publications

Rosson, G.B., Vincent, T.S., Oswald, B.W., and Wright, C.F.  Drug resistance in malignant rhabdoid tumor cell lines.  Cancer Chemother Pharmacol 2002;49:142-148.  PMID 11862428
 
Reincke, B.S., Rosson, G.B., Oswald, B.W., and Wright, C.F.  INI1 expression induces cell cycle arrest and markers of senescence in malignant rhabdoid tumor cells.  J Cell Physiol, 2003; 194:303-313.  PMID 12548550
 
Foster. K.S.J., McCrary, W.J., Ross, J.S., and Wright, C.F.  Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt.  Oncogene, 2006; 25:4605-4612.  PMID 16568092
 
Foster, K.S.J., Wang, Y., Zhou, D., and Wright, C.F. Dependence on PI3K/Akt signaling for malignant rhabdoid tumor cell survival.  Cancer Chemother Pharmacol, 2009; 63:783-791.  PMID 18641990

Research Support

Title: MUSC Short-Term Research Education Program to Increase Diversity
Agency: National Heart, Lung, and Blood Institute

Role: PI
Funding Period: 05/10/2008 - 04/30/2013

Title: MUSC Initiative for Maximizing Student Diversity
Agency: National Institute of General Medical Sciences
Role: PI
Funding Period: 03/01/2005 – 04/30/2014

Title: MUSC-Claflin Cooperative for Postdoctoral Academic Career Development
Agency: National Institute of General Medical Sciences
Role: PI
Funding Period: 08/01/2007 – 07/31/2012

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