Department of Microbiology and Immunology
|Dr. Zihai Li, M.D., Ph.D.|
Professor and Chairman
The Department of Microbiology & Immunology works to understand and eliminate disease-causing microbes; and elucidate mechanisms and harness the power of the host immune system to fight against infections, cancer and other diseases. Faculty and staff concentrate on the following fields of study: cancer immunology; immunogenetics; innate immunity; inflammation; autoimmunity; microbiology; and transplant immunology. Currently we have 28 primary faculty members, 16 joint-appointees and 5 Professors Emeritus. Accomplishments over the past year include receipt of 17 new research grants (12 from NIH) and publication of 125 journal articles. Our sponsored research stands at $12.9 M, of which $9 M (70%) is from NIH. In fact, in an effort to advance to the top 30 in the nation for NIH funding, the Department’s rank has steadily improved from #79 (2009) to #31 (2017) nationally.
The Department maintains strong collaborative ties with the National Cancer Institute-designated Hollings Cancer Center through the Cancer Immunology Research Program, which allows us to have access to the state-of-the-art research facilities including a flow cytometry core, transgenic and gene-targeting core, tissue repository core, drug discovery core, and the Center for Cellular Therapy core. To understand the impact of microbiota to health and diseases, the research in our department is also supported by a unique Gnotobiotic Core in close collaboration with the College of Dental Medicine. The Department has recently established the Immune Monitoring and Discovery (IMD) Core which contains a FlexMap3D multiplexing platform and the state-of-art mass cytometry-based cellular analysis instrumentation, Helios (CyTOF). Core functions include custom development of new reagents and immunoassays, guidance on selecting existing assays, and awareness/training on new immunoassay platforms.
We pursue our research goals in a programmatic and multidisciplinary fashion with the aim of improving our knowledge of the fundamentals and molecular mechanisms involved in the immune response and microbial pathogenesis, while keeping the clinical translation of this research within our vision.
Our robust research activity is a perfect complement to our education program, which features graduate courses as well as medical and dental education. Our Distinguished Seminar Series allows us to invite visiting professors and guest lecturers from the leading institutes and biotech companies around the country. In recognition of educational excellence, members of our faculty have received teaching awards and several students and postdocs were accepted to T32 trainee programs. Additionally, the Department was recently awarded a prestigious T32 Award from NIAID titled “Program in Immunology Research and Entrepreneurship (PIRE)” to train future generations of immunologists and entrepreneurs. The T32 is a part of our Immunology Training Program: a broad-based interdepartmental training program that reflects the research interests of faculty at MUSC and the Charleston VA Medical Center. The program covers the three basic areas of immunology: innate immunity, T cell biology, and antibodies/B cell biology.