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 Marine Biomedicine and Environmental Sciences | Faculty | John E. Baatz, Ph.D.

John E. Baatz, Ph.D.

Research Interest:
The focus of the research projects in our laboratory is the effects of hypoxic stress and marine-borne toxin exposure on the distal lung, specifically with respect to responses of alveolar cells.  This research currently encompasses four research projects. The first of these examines the roles of hemoglobin, recently identified by our laboratory as being expressed in alveolar type II cells, in nitrosative and oxidative stress as well as surfactant protein expression.  Secondly we are developing a porous hollow fiber system that permits culture of embryonic stem cells, primary airway cells and immortalized airway cells within the fiber at an air/water interface. We are also using this system to assess adaptations diving marine mammals (such as dolphins, seals and whales) have made to repetitive hypoxic conditions while being able to maintain lung health. This unique technique may be useful in reducing the use of animals in studying distal lung during health, disease or injury, and may also serve as a system to repopulate diseased or injured airway cells with health cells. We continue to examine structural/function relationships of pulmonary surfactant proteins and the effects of marine-borne toxins (such as red-tide toxins) on lung health. This is an exciting untapped field of study and has direct impacts on human lung health since humans share the often-polluted coastal waters, whether by recreation or work related, with dolphins, whales and manatees. This project utilizes proteomic and molecular biologic techniques in an effort to identify proteins and specific mechanistic pathways in airway cells that are altered in expression or secretion as a result of toxin exposure.  Finally, as Director of the MUSC Gel Proteomics facility, I am interested in development of novel separations and labeling techniques to identify, in a variety of species, disease-specific protein biomarkers and effects of drugs or stress on subcellular organelle proteins.

Selected Publications:
 - Sinha R, Pinto JT, Facompre N, Kilheffer J, Baatz JE, El-Bayoumy K. Effects of Naturally Occurring and Synthetic Organoselenium Compounds on Protein Profiling in Androgen Responsive and Androgen Independent Human Prostate Cancer Cells. Nutrition and Cancer, 2008 60(2), 267–275.

 - Skinner ML+, Schlosser RJ, Lathers D, Neal JG+, Woodworth BA+, Hall J, Newton DA, Baatz JE. Innate and adaptive mediators in cystic fibrosis and allergic fungal rhinosinusitis. American Journal of Rhinology 2007 21(5):538-41.

 - Nagai1 R, Brock JW, Blatnik M, Baatz JE, Bethard J, Walla MD, Thorpe SR, Baynes JW, Frizzell N#. Succination of protein thiols during adipocyte maturation –a biomarker of mitochondrial stress. J Biol Chem 2007 282: 34219 - 34228.

 - Yu H, Buff SM#, Baatz JE, Virella-Lowell I. Oral Instillation with Surfactant Phospholipid: A Reliable Alternative to Intra-tracheal Injection in Mice Studies. Laboratory Animals 2007 (In Press)

 - Woodworth BA+, Wood R, Bhargave G+, Cohen NA+, Baatz JE, Schlosser RJ. Surfactant protein B detection and gene expression in chronic rhinosinusitis. Laryngoscope 2007 Jul ;117(7):1296-301.

 - Woodworth B+, Wood R, Baatz JE, Schlosser R. Sinonasal surfactant protein A1, A2, and D gene expression in cystic fibrosis: A preliminary report. Otolaryngology - Head and Neck Surgery 2007. 137:34-38.

John E. Baatz, Ph.D.

John E. Baatz, Ph.D.

Interim Director, Marine Biomedicine & Environmental Sciences Center & Professor of Pediatrics Department of Biochemistry & Molecular Biology, MUSC

Ph.D. University of Cincinnati

Dr. Baatz's Contact Information

Hollings Marine Lab
331 Ft Johnson Rd.
Charleston, SC 29412

Phone: (843)792-1049