Lisa J. Bain, Ph.D.

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Marine Biomedicine and Environmental Sciences | Faculty | Lisa J. Bain, Ph.D.

Lisa J. Bain, Ph.D.

Research Interest:
Environmental toxicology and marine functional genomics. Research focuses on examining altered gene expression in fish after exposure to contaminants such as chromium, arsenic, and polycyclic aromatic hydrocarbons. We are interested in ascertaining what genes are being altered, what the resulting consequence or cost is to the organism, and whether these genes can be used as biomarker probes to assess exposure to other contaminants. The current project is specifically examining environmentally realistic concentrations of arsenic to ascertain its mechanism of developmental toxicity.

Selected Publications:
1. Tribull TE, Bruner RH, and Bain LJ (2003) The Multidrug Resistance-Associated Protein 1 (MRP1/ABCC1) transports methoxychlor and protects the seminiferous epithelium from injury, Toxicology Letters, 142:61-70.

2. Bain LJ and Feldman RA (2003) Altered expression of sulfotransferases, glucuronosyltransferases, and MRP transporters in FVB/mrp1-/- mice, Xenobiotica, 33:1173-1184.

3. Maples NL and Bain LJ (2004) Trivalent chromium alters gene expression in the mummichog (Fundulus heteroclitus), Environmental Toxicology and Chemistry, 23:626-631.

4. Peterson JSK and Bain LJ (2004) Differential gene expression in anthracene-exposed mummichogs (Fundulus heteroclitus), Aquatic Toxicology, 66:345-355.

5. Roling JA, Bain LJ, and Baldwin WS (2004) Differential gene expression in mummichogs (Fundulus heteroclitus) following treatment with pyrene: comparison to a creosote contaminated site, Marine Environmental Research, 57:355-395.

Lisa J. Bain, Ph.D.