William S. Baldwin, Ph.D.
My research focuses on toxicant-induced changes in gene expression mediated through the nuclear receptors, CAR and PXR. I am particularly interested in endocrine disrupting chemicals and their ability to activity CAR and PXR and in turn induce P450 expression or cause P450-synergized toxicity of pesticides and other environmental chemicals. This work also includes the study of chemical mixtures on CAR and PXR activity because we are not exposed to only one chemical at a time.
My laboratory is also involved in the Fundulus and Daphnia Genomics Consortiums. I am currently annotating the P450 family in the Daphnia pulex genome. We also investigate global changes in gene expression caused by reproductive or aquatic toxicants in collaboration with Dr. Lisa Bain. We are using Fundulus heteroclitus (mummichog) microarrays as a biomarker for determining the efficacy of remediation at coastal Superfund sites.
Selected Publications:1. Baldwin, W.S., Marko, P.B., Nelson, D.R. The cytochrome P450 (CYP) gene superfamily in Daphnia pulex. BMC Genomics. Submitted and in revision (accepted with minor revisions).
2. Burnett, K.G., Bain, L.J., Baldwin, W.S., Callard, G.V., Cohen, S., Di Giulio, R.T., Evans, D.H., Gomez-Chiarri, M., Hahn, M.E., Hoover, C.A., Karchner, S.I., Katoh, F., MacLatchy, D.L., Marshall, W.S., Meyer, J.N., Nacci, D.E., Oleksiak, M.F., Rees, B.B., Singer, T.D., Stegeman, J.J., Towle, D.W., Van Veld, P.A., Vogelbein, W.K., Whitehead, A., Winn, R.N., Crawford, D.L. (2007) Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics. Comp Biochem Physiol D: Genomics and Proteomics., 2: 257-286.
3. Saldivar, S.J., Lopez, D., Feldman, R.A., Jacobs, R., de la Rosa, A., Terreros, D., Baldwin, W.S. (2007) COX-2 overexpression as a biomarker of cervical carcinogenesis: a pilot study. Gynecol Oncol., 107: S155-S162.
4. Hernandez, J.P., Huang, W., Chapman, L.M., Chua, S., Moore, D.D, Baldwin, W.S. (2007) The environmental estrogen, nonylphenol, activates the constitutive androstane receptor (CAR). Toxicol. Sci., 98: 416-426.
5. Roling, J.A., Bain, L.J., Gardea-Torresdey, J., Key, P.B., Baldwin, W.S. (2007) Using mummichog (Fundulus heteroclitus) arrays to monitor the effectiveness of remediation at a superfund site in Charleston, South Carolina. Environ Toxicol Chem., 26: 1205-1213.
|William S. Baldwin, Ph.D.|
|Associate Professor, Institute of Environmental Toxicology|
Clemson University, Clemson SC
Ph.D., North Carolina State University