Wayne R. Fitzgibbon, Ph.D.

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Marine Biomedicine and Environmental Sciences | Faculty | Wayne R. Fitzgibbon, Ph.D.

Wayne R. Fitzgibbon, Ph.D.

Research Interest:
Integration of physiological and molecular approaches to understanding the mechanisms involved in the regulation of renal function in elasmobranch fish and in mammals. Our research with elasmobranchs is focused on the renal mechanisms involved in volume- and osmo-regulation, specifically the role of urea transporters and aquaporins. Recent studies have involved the determination of parameters of renal function in stingrays, as well as, the cloning and identification of several isoforms of urea transporters from batoid elasmobranchs. New projects include the identification of sites within the kidney for urea and other membrane transporter protein expression.

Selected Publications:
1. Fitzgibbon, W.R., and Ploth, D.W. (2008). Effect of acute saline expansion on the renal vascular resistance of 2-K, 1C hypertensive Sprague Dawley (SD) and Dahl salt resistant rats (SR/Jr). in preparation

2. Fitzgibbon, W.R., and Ploth, D.W. (2008). Resistance of Dahl salt resistant rats (SR/Jr) to the early phase of 2-K, 1C hypertension: effect of dietary salt. in preparation

3. Dempsey, A., Lacy, E.R., Janech, M.G., Miller, D.H., Roumillat W., Burnett, L., Ploth, D.W. and Fitzgibbon, W.R. (2008). Effect of Low Salinity on the Localization of Na+/K+ATPase and NKCC2 in Tubular Segments in the Kidney of the Euryhaline Stingray, Dasyatis sabina. in preparation for submission to Am J Physiol Renal

4. Dempsey, A., Lacy, E.R., Janech, M.G., Miller, D.H., Roumillat W., Burnett, L., Ploth, D.W. and Fitzgibbon, W.R. (2008). Localization of Urea Transporters to Tubular Segments in the Bundle and Sinus Zones of the Kidney of the Euryhaline Stingray, Dasyatis sabina: Effect of Low Salinity. in preparation for submission to Am J Physiol Renal

5. Sivritas, H.S., Ploth D.W. and Fitzgibbon, W.R., (2008). Blockade of Renal Medullary Bradykinin B2 Receptors Increases Sodium Reabsorption in Rats Fed a Normal Salt Diet. In revision Am J Physiol Renal

Wayne R. Fitzgibbon, Ph.D.