Mark S. Kindy, Ph.D.

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Marine Biomedicine and Environmental Sciences | Faculty | Mark S. Kindy, Ph.D.

Mark S. Kindy, Ph.D.

Research Interest:
My research focus is on the developing and aging nervous system of humans and marine mammals. Specific emphasis is directed towards neuroinflammatory diseases. Recent work has begun to examine the role of environmental toxins on the nervous system in the mouse models. Dissection of the signaling pathways that lead to apoptotic and non-caspase mediated cell death are the important aspects of this work and may lead to the development of therapeutic agents. Other areas of our work are focused on understanding the neurotoxic effects of marine biotoxins originating from dinoflagellates. Both in vitro and in vivo models are used to study the effects of these toxins in the nervous system. Additionally, our aim is to address human health problems through chemical and biological research on compounds derived from marine organisms. Using cell culture and mouse models of human diseases, we are screening chemical components derived from these organisms to identify potential new therapeutic agents for treating human diseases, such as stroke and Alzheimer’s disease.

Selected Publications:
1. Chi LY, Yu J, Zhu H, Li XG, Zhu SG, Kindy MS. The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury. Neurosci Lett. 2008 Jun 20;438(2):174-9.

2. Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 May 14. [Epub ahead of print]

3. El-Amouri, S.S, Zhu, H., Yu, J., Gage, F.H., Verma, I.M., Kindy. M.S. Neprilysin: an enzyme candidate to treat Alzheimer’s disease. Amer. J. Path., in press. Am J Pathol. 2008, 172:1342-54.

4. Hook VY, Kindy MS, Hook G. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. J Biol Chem. 2008, 283:7745-53.

5. Govindaswami, M, Brown SA, Yu, J, Zhu, H, Bishop, PD, Kindy, MS, Oeltgen, PR. Delta2 Specific Opioid Receptor Agonist and Hibernating Woodchuck Plasma Fraction Provide Ischemic Neuroprotection. Acad Emerg Med. Acad Emerg Med. 2008 Mar;15(3):250-7.

Mark S. Kindy, Ph.D.